Active Recombinant Human TIGIT, Fc-tagged

• Cat.No.: TIGIT-105H
• Product Overview: Recombinant Human TIGIT (Met22-Pro141) with Fc tag was expressed in CHO Cells.

Specification

• Description: This gene encodes a member of the PVR (poliovirus receptor) family of immunoglobin proteins. The product of this gene is expressed on several classes of T cells including follicular B helper T cells (TFH). The protein has been shown to bind PVR with high affinity; this binding is thought to assist interactions between TFH and dendritic cells to regulate T cell dependent B cell responses.
• Source: CHO Cells
• Species: Human
• Tag: Fc
• Predicted N Terminal: Met22
• Form: Lyophilized from a 0.2 μm filtered solution in PBS.?
• Bio-activity: Measured by its binding ability in a functional ELISA. When Recombinant Human CD155/PVR is coated at 2.5?μg/mL (100?μL/well), the concentration of Recombinant Human TIGIT Fc Chimera that produces 50%?optimal binding response is typically?20-100 ng/mL.
• Molecular Mass: 39.6 kDa (monomer)
• Purity: >95%, by SDS-PAGE under reducing conditions and visualized by silver stain.
• Storage: Avoid repeated freeze-thaw cycles.12 months from date of receipt, -20 to -70 °C as supplied.1 month, 2 to 8 °C under sterile conditions after reconstitution.3 months, -20 to -70 °C under sterile conditions after reconstitution.
• Reconstitution: Reconstitute at 100 μg/mL in PBS.

Gene Information

• Gene Name: TIGIT?T cell immunoreceptor with Ig and ITIM domains [?Homo sapiens?(human) ]
• Official Symbol: TIGIT
• Synonyms: TIGIT; VSIG9; VSTM3; WUCAM; T cell immunoreceptor with Ig and ITIM domains; T-cell immunoreceptor with Ig and ITIM domains; V-set and transmembrane domain containing 3; V-set and immunoglobulin domain containing 9; Washington University cell adhesion molecule; V-set and transmembrane domain-containing protein 3; V-set and immunoglobulin domain-containing protein 9
• Gene ID: 201633
• mRNA Refseq: NM_173799
• Protein Refseq: NP_776160
• MIM: 612859
• UniProt ID: Q495A1
• Chromosome Location: 3q13.31
• Pathway: Cell adhesion molecules (CAMs)
• Function: protein binding; receptor binding