Active Recombinant Human TNFRSF17, Fc-tagged, Biotinylated

Cat.No. : TNFRSF17-552H
Product Overview : The recombinant human BCMA-Fc fusion is expressed as a 281 amino acid protein consisting of Leu2 - Ala54 region of BCMA (UniProt accession #Q02223) and a C-terminal Fc from human IgG1, which exists as a dimer under non-reducing conditions.
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Source : Human cells
Species : Human
Tag : Fc
Form : Supplied at 0.5 mg/ml in sterile PBS pH7.4 (carrier & preservative free). The purified recombinant protein was labeled with Biotin (3-5 Biotin per molecule).
Bio-activity : Binds to its ligand APRIL and BAFF. Inhibits APRIL-- and BAFF-mediated signaling activities including NF-κB activation and proliferation of anti--IgM co-stimulated B cells.
Molecular Mass : Calculated molecular mass (kDa): 31.3; Estimated by SDS-PAGE under reducing condition (kDa): ~45
Endotoxin : <0.1 eu per 1 μg of purified recombinant protein determined by the
Purity : >95% judged by SDS-PAGE under reducing condition
Storage : The product is shipped at 4°C. Upon receipt, centrifuge the product briefly before opening the vial. It is recommended to store small aliquots at the temperature below –20°C for long-term storage and the product is stable for 3 months. The undiluted protein can be stored at 4°C for no more than 2 weeks. Avoid repeated freeze-thaw cycles.
Publication :
Changes in Bone Marrow Tumor and Immune Cells Correlate with Durability of Remissions Following BCMA CAR T Therapy in Myeloma (2022)
Gene Name : TNFRSF17 tumor necrosis factor receptor superfamily, member 17 [ Homo sapiens ]
Official Symbol : TNFRSF17
Synonyms : TNFRSF17; tumor necrosis factor receptor superfamily, member 17; BCMA; tumor necrosis factor receptor superfamily member 17; BCM; CD269; B-cell maturation factor; B cell maturation antigen; B-cell maturation protein;
Gene ID : 608
mRNA Refseq : NM_001192
Protein Refseq : NP_001183
MIM : 109545
UniProt ID : Q02223
Chromosome Location : 16p13.1
Pathway : Cytokine-cytokine receptor interaction, organism-specific biosystem; Cytokine-cytokine receptor interaction, conserved biosystem; Intestinal immune network for IgA production, organism-specific biosystem; Intestinal immune network for IgA production, conserved biosystem;
Function : receptor activity; tumor necrosis factor-activated receptor activity;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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