Active Recombinant Human TNFRSF17 protein, Fc-tagged

Cat.No. : TNFRSF17-1817H
Product Overview : Human BCMA, Fc Tag is expressed from human 293 cells (HEK293). It contains AA Met 1 - Ala 54 (Accession # NP_001183.2).
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Description : Tumor necrosis factor receptor superfamily member 17 (TNFRSF17) is also known as B-cell maturation protein (BCMA), CD antigen CD269, which is a member of the TNF-receptor superfamily. TNFRSF17 contains one TNFR-Cys repeat. TNFRSF17 is expressed in mature B-cells, but not in T-cells or monocytes. TNFRSF17 is receptor for TNFSF13B/BLyS/BAFF and TNFSF13/APRIL. TNFRSF17 promotes B-cell survival and plays a role in the regulation of humoral immunity. TNFRSF17 can activate NF-kappa-B and JNK.
Source : HEK293
Species : Human
Tag : Fc
Predicted N Terminal : Met 1
Form : Lyophilized from 0.22 μm filtered solution in 50 mM tris, 100 mM glycine, pH7.5, 10% trehalose.
Bio-activity : Immobilized Human BCMA, Fc Tag at 10μg/mL (100 μL/well) can bind FITC-Labeled Human BAFF, Fc Tag with a linear range of 0.31-1.25 μg/mL.
Molecular Mass : This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 32 kDa. As a result of glycosylation, The protein migrates as 35-40 kDa under reducing (R) condition and 66 kDa under non-reducing (NR) condition on SDS-PAGE gel.
Protein length : AA Met 1 - Ala 54
Endotoxin : Less than 1.0 EU per μg by the LAL method.
Purity : >95% as determined by SDS-PAGE.
Storage : For long term storage, the product should be stored at lyophilized state at -20°C or lower. Please avoid repeated freeze-thaw cycles. No activity loss is observed after storage at: 4-8°C for 12 months in lyophilized state; -70°C for 3 months under sterile conditions after reconstitution.
Reconstitution : It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4℃ before opening to recover the entire contents.
SDS-PAGE: Human BCMA, Fc Tag on SDS-PAGE under reducing (R) and no-reducing (NR) conditions. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%.
Gene Name : TNFRSF17 TNF receptor superfamily member 17 [ Homo sapiens (human) ]
Official Symbol : TNFRSF17
Synonyms : BCM; BCMA; CD269; TNFRSF13A; B cell maturation antigen; B-cell maturation factor; B-cell maturation protein
Gene ID : 608
mRNA Refseq : NM_001192.2
Protein Refseq : NP_001183.2
UniProt ID : Q02223

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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