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Active Recombinant Human TNFRSF17 Protein, Fc-tagged, Alexa Fluor 647 conjugated

Cat.No. : TNFRSF17-2070HAF647
Product Overview : Alexa Fluor 647 conjugated recombinant human TNFRSF17 is produced inHEK 293 Cellswith the C-terminus to the Fc portion of human IgG1. MW=42kDa.
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Description : The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is preferentially expressed in mature B lymphocytes, and may be important for B cell development and autoimmune response. This receptor has been shown to specifically bind to the tumor necrosis factor (ligand) superfamily, member 13b (TNFSF13B/TALL-1/BAFF), and to lead to NF-kappaB and MAPK8/JNK activation. This receptor also binds to various TRAF family members, and thus may transduce signals for cell survival and proliferation.
Source : HEK293
Species : Human
Tag : Fc
Form : Lyophilized
Bio-activity : Blocks the binding of BAFF and APRIL to their receptors BCMA and TACI, inhibiting BAFF- and APRIL-mediated B cell activation.
Endotoxin : < 0.1 EU/ μg purified protein (LAL test; BioWhittaker).
Purity : ≥95 % by SDS-PAGE
Characteristic : Disulfide-linked homodimer
Labeled with Alexa Fluor 647 via amines
Excitation = 650 nm
Emission = 668 nm
Applications : Flow Cytometry: Detection of membrane-bound mouse BAFF and human APRIL in combination with fluorescently labelled Ab to IgG1.
Storage : Stable for at least 6 months after receipt when stored at -20 centigrade. Avoid freeze/thaw cycles.
Concentration : 1 mg/mL
Storage Buffer : Contains PBS.
Reconstitution : Reconstitute with 50 μl of sterile water. Further dilutions should be made with medium containing 5% fetal calf serum or a carrier protein.
Gene Name : TNFRSF17 tumor necrosis factor receptor superfamily, member 17 [ Homo sapiens ]
Official Symbol : TNFRSF17
Synonyms : TNFRSF17; tumor necrosis factor receptor superfamily, member 17; BCM; BCMA; CD269; TNFRSF17; tumor necrosis factor receptor superfamily member 17; B-cell maturation factor; B-cell maturation protein
Gene ID : 608
mRNA Refseq : NM_001192
Protein Refseq : NP_001183
MIM : 109545
UniProt ID : Q02223

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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