Active Recombinant Human TNFRSF4, MIgG2a Fc-tagged

• Cat.No.: TNFRSF4-520H
• Product Overview: The extracellular domain of human CD134 (NP_003318.1) (Leu29-Ala216) is fused to the N-terminus of the Fc region of mouse IgG2a was expressed in CHO cell.

Specification

• Species: Human
• Source: CHO
• Tag: Fc
• Protein Length: 29-216 a.a.
• Description: The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor has been shown to activate NF-kappaB through its interaction with adaptor proteins TRAF2 and TRAF5. Knockout studies in mice suggested that this receptor promotes the expression of apoptosis inhibitors BCL2 and BCL2lL1/BCL2-XL, and thus suppresses apoptosis. The knockout studies also suggested the roles of this receptor in CD4+ T cell response, as well as in T cell-dependent B cell proliferation and differentiation.
• Form: Lyophilized from 0.2μm-filtered solution in PBS.
• Bio-activity: Measured by its binding ability in a functional ELISA.
• Molecular Mass: 46KDa (monomer)
• AA Sequence: Leu29-Ala216
• Endotoxin: <0.06 eu/μg="" as="" determined="" by="" lal="" test.="">
• Purity: >98%, by SDS-PAGE under reducing conditions.
• Stability: Stable for at least 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.
• Reconstitution: Reconstitute at 100μg/ml in sterile PBS.
• Warning: Avoid freeze/thaw cycles.

Gene Information

• Gene Name: TNFRSF4 tumor necrosis factor receptor superfamily, member 4 [ Homo sapiens ]
• Official Symbol: TNFRSF4
• Synonyms: TNFRSF4; tumor necrosis factor receptor superfamily, member 4; TXGP1L; tumor necrosis factor receptor superfamily member 4; ACT35; CD134; OX40; OX40 antigen; ACT35 antigen; ATC35 antigen; CD134 antigen; OX40 homologue; OX40L receptor; OX40 cell surface antigen; lymphoid activation antigene ACT35; TAX transcriptionally-activated glycoprotein 1 receptor; tax-transcriptionally activated glycoprotein 1 receptor
• Gene ID: 7293
• mRNA Refseq: NM_003327
• Protein Refseq: NP_003318
• MIM: 600315
• UniProt ID: P43489
• Chromosome Location: 1p36
• Pathway: Cytokine-cytokine receptor interaction, organism-specific biosystem; Cytokine-cytokine receptor interaction, conserved biosystem; Downstream signaling in naive CD8+ T cells, organism-specific biosystem
• Function: binding; receptor activity; tumor necrosis factor-activated receptor activity