Active Recombinant Human TNFRSF4, MIgG2a Fc-tagged
Cat.No. : | TNFRSF4-520H |
Product Overview : | The extracellular domain of human CD134 (NP_003318.1) (Leu29-Ala216) is fused to the N-terminus of the Fc region of mouse IgG2a was expressed in CHO cell. |
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Description : | The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor has been shown to activate NF-kappaB through its interaction with adaptor proteins TRAF2 and TRAF5. Knockout studies in mice suggested that this receptor promotes the expression of apoptosis inhibitors BCL2 and BCL2lL1/BCL2-XL, and thus suppresses apoptosis. The knockout studies also suggested the roles of this receptor in CD4+ T cell response, as well as in T cell-dependent B cell proliferation and differentiation. |
Source : | CHO cell |
Species : | Human |
Tag : | MIgG2a Fc-tagged |
Form : | Lyophilized from 0.2μm-filtered solution in PBS. |
Bio-activity : | Measured by its binding ability in a functional ELISA. |
Molecular Mass : | 46KDa (monomer) |
AA Sequence : | Leu29-Ala216 |
Endotoxin : | <0.06 eu/μg as determined by lal test.>0.06> |
Purity : | >98%, by SDS-PAGE under reducing conditions. |
Stability : | Stable for at least 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C. |
Reconstitution : | Reconstitute at 100μg/ml in sterile PBS. |
Warning : | Avoid freeze/thaw cycles. |
Gene Name : | TNFRSF4 tumor necrosis factor receptor superfamily, member 4 [ Homo sapiens ] |
Official Symbol : | TNFRSF4 |
Synonyms : | TNFRSF4; tumor necrosis factor receptor superfamily, member 4; TXGP1L; tumor necrosis factor receptor superfamily member 4; ACT35; CD134; OX40; OX40 antigen; ACT35 antigen; ATC35 antigen; CD134 antigen; OX40 homologue; OX40L receptor; OX40 cell surface antigen; lymphoid activation antigene ACT35; TAX transcriptionally-activated glycoprotein 1 receptor; tax-transcriptionally activated glycoprotein 1 receptor; |
Gene ID : | 7293 |
mRNA Refseq : | NM_003327 |
Protein Refseq : | NP_003318 |
MIM : | 600315 |
UniProt ID : | P43489 |
Chromosome Location : | 1p36 |
Pathway : | Cytokine-cytokine receptor interaction, organism-specific biosystem; Cytokine-cytokine receptor interaction, conserved biosystem; Downstream signaling in naive CD8+ T cells, organism-specific biosystem; |
Function : | binding; receptor activity; tumor necrosis factor-activated receptor activity; |
Products Types
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TNFRSF4-2034H | Recombinant Human TNFRSF4 Protein, MYC/DDK-tagged | +Inquiry |
TNFRSF4-2764H | Recombinant Human TNFRSF4 protein(141-210 aa), C-His-tagged | +Inquiry |
Tnfrsf4-547M | Recombinant Mouse Tnfrsf4 Protein | +Inquiry |
◆ Lysates | ||
TNFRSF4-2422HCL | Recombinant Human TNFRSF4 cell lysate | +Inquiry |
TNFRSF4-1762MCL | Recombinant Mouse TNFRSF4 cell lysate | +Inquiry |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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