Active Recombinant Human TNFRSF4 Protein, His-tagged
Cat.No. : | TNFRSF4-523H |
Product Overview : | Recombinant Human TNFRSF4 Protein extracellular domain 29-214aa (signal peptide removed), fused with a C-terminal His tag, was expressed in CHO. |
- Specification
- Gene Information
- Related Products
Description : | OX40 (CD134) and its binding partner, OX40L (CD252), are members of the tumor necrosis factor receptor/tumor necrosis factor superfamily, is known to break an existing state of tolerance in malignancies, leading to a reactivation of antitumor immunity. The interaction between OX40 and OX40L plays an important role in antigen-specific T-cell expansion and survival. OX40 and OX40L also regulate cytokine production from T cells, antigen-presenting cells, natural killer cells, and natural killer T cells, and modulate cytokine receptor signaling. In line with these important modulatory functions, OX40-OX40L interactions have been found to play a central role in the development of multiple inflammatory and autoimmune diseases, making them attractive candidates for intervention in the clinic. Conversely, stimulating OX40 has shown it to be a candidate for therapeutic immunization strategies for cancer and infectious disease. |
Source : | CHO |
Species : | Human |
Tag : | His |
Predicted N Terminal : | Leu 29 |
Form : | Lyophilized from sterile PBS, pH 7.4. |
Bio-activity : | Measured by its binding ability in a functional ELISA. |
Molecular Mass : | The recombinant mature human OX40 protein consists of 192 amino acids and has a calculated molecular mass of 20.8 KD. |
Endotoxin : | <1.0EU/ug, LAL method |
Purity : | >95% (SDS-PAGE) |
Stability : | Samples are stable for up to twelve months from date of receipt at -70ºC. |
Storage : | Store it under sterile conditions at -20ºC~-70ºC. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. |
Reconstitution : | It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4℃ before opening to recover the entire contents. |
Gene Name : | TNFRSF4 tumor necrosis factor receptor superfamily, member 4 [ Homo sapiens ] |
Official Symbol : | TNFRSF4 |
Synonyms : | TNFRSF4; tumor necrosis factor receptor superfamily, member 4; TXGP1L; tumor necrosis factor receptor superfamily member 4; ACT35; CD134; OX40; OX40 antigen; ACT35 antigen; ATC35 antigen; CD134 antigen; OX40 homologue; OX40L receptor; OX40 cell surface antigen; lymphoid activation antigene ACT35; TAX transcriptionally-activated glycoprotein 1 receptor; tax-transcriptionally activated glycoprotein 1 receptor; |
Gene ID : | 7293 |
mRNA Refseq : | NM_003327 |
Protein Refseq : | NP_003318 |
MIM : | 600315 |
UniProt ID : | P43489 |
Chromosome Location : | 1p36 |
Pathway : | Cytokine-cytokine receptor interaction, organism-specific biosystem; Cytokine-cytokine receptor interaction, conserved biosystem; Downstream signaling in naive CD8+ T cells, organism-specific biosystem; |
Function : | binding; receptor activity; tumor necrosis factor-activated receptor activity; |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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