Active Recombinant Human USP28 protein, His-tagged
Cat.No. : | USP28-23H |
Product Overview : | Recombinant Human USP28(Asp155-Ile707) fused with His tag at C-terminal was expressed in Insect cells. |
- Specification
- Gene Information
- Related Products
Description : | USP28 is a deubiquitinating enzyme of the C19 peptidase family that regulates MYC stability and DNA damage response checkpoints. USP28 regulates DNA repair by deubiquitinating and thereby stabilizing CLSPN - a protein that is ubiquitinated by the APC/C E3 Ubiquitin ligase in a cell-cycle dependent manner. USP28 interacts with isoform 1 of FBXW7 in the nucleoplasm, and regulates MYC degradation by counteracting its ubiquitination. Recently, a potential role in HIF-1 alpha -dependent processes such as angiogenesis and metastasis has been described for this deubiquitinase. USP28 has been demonstrated to cleave K6, K11, K48, and K63-linked poly-Ubiquitin chains. This recombinant protein contains a C-terminal 6-His tag. |
Source : | Insect cells |
Species : | Human |
Tag : | His |
Form : | X mg/ml (X μM) in 50 mM Hepes pH 7.5, 100 mM NaCl, 1 mM TCEP |
Bio-activity : | Recombinant Human USP28 is a Ubiquitin-specific deconjugating enzyme. Reaction conditions will need to be optimized for each specific application. We recommend an initial Recombinant Human USP28 concentration of 10-500 nM. |
Molecular Mass : | 123 kDa |
Purity : | >90%, by SDS-PAGE under reducing conditions and visualized by Colloidal Coomassie® Blue stain |
Gene Name : | USP28 ubiquitin specific peptidase 28 [ Homo sapiens ] |
Official Symbol : | USP28 |
Synonyms : | USP28; ubiquitin specific peptidase 28; ubiquitin specific protease 28; ubiquitin carboxyl-terminal hydrolase 28; KIAA1515; ubiquitin thioesterase 28; deubiquitinating enzyme 28; ubiquitin thiolesterase 28; ubiquitin-specific-processing protease 28; |
Gene ID : | 57646 |
mRNA Refseq : | NM_020886 |
Protein Refseq : | NP_065937 |
MIM : | 610748 |
UniProt ID : | Q96RU2 |
Chromosome Location : | 11q23 |
Function : | cysteine-type peptidase activity; peptidase activity; protein binding; ubiquitin thiolesterase activity; ubiquitin thiolesterase activity; ubiquitin-specific protease activity; |
Products Types
◆ Recombinant Protein | ||
USP28-9957M | Recombinant Mouse USP28 Protein, His (Fc)-Avi-tagged | +Inquiry |
USP28-0345H | Recombinant Human USP28 Protein (T2-K1077), Tag Free | +Inquiry |
Usp28-6873M | Recombinant Mouse Usp28 Protein, Myc/DDK-tagged | +Inquiry |
USP28-0346H | Recombinant Human USP28 Protein (T2-K1077), His tagged | +Inquiry |
USP28-6131R | Recombinant Rat USP28 Protein, His (Fc)-Avi-tagged | +Inquiry |
◆ Lysates | ||
USP28-1895HCL | Recombinant Human USP28 cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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