Active Recombinant Human VEGFA
Cat.No. : | VEGFA-543H |
Product Overview : | Human VEGFA (NP_001020541, 207 a.a.-327 a.a.) partial recombinant protein with His tag expressed in Escherichia coli. |
- Specification
- Gene Information
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Cat. No. : | VEGFA-543H |
Description : | Vascular endothelial growth factor A (VEGF-A) is a protein that in humans is encoded by the VEGFA gene. |
Sequence : | MGSSHHHHHH SSGLVPRGSH MAPMAEGGGQ NHHEVVKFMD VYQRSYCHPI ETLVDIFQEY PDEIEYIFKP SCVPLMRCGG CCNDEGLECV PTEESNITMQ IMRIKPHQGQ HIGEMSFLQH NKCECRPKKD RARQEKCDKP RR |
Theoretical MW (kDa) : | 16.3 |
Form : | Liquid |
Preparation Method : | E. coli expression system |
Purity : | > 95% by SDS-PAGE |
Endotoxin Level : | < 1.0 EU per 1 microgram of protein (determined by LAL method) |
Activity : | The ED50 for this effect is < 4.2 ng/mL. Measured in a cell proliferation assay using NIH-3T3 cell. |
Application : | SDS-PAGE |
Storage Buffer : | In 20 mM Tris, pH 8.0 |
Storage : | Store at 4°C for 1-2 weeks. For long term storage store at -20°C or -80°C. |
Unitprot ID : | P15692 |
Gene Name : | VEGFA vascular endothelial growth factor A [ Homo sapiens ] |
Official Symbol : | VEGFA |
Synonyms : | VPF; VEGF; VEGFA_HUMAN; Vascular permeability factor; VEGF-A; VEGFA; MGC70609; Vegf120; Vegf164; Vegf188; vascular endothelial growth factor A; MGC70609; Vascular endothelial growth factor A precursor; Vascular permeability factor |
Gene ID : | 7422 |
mRNA Refseq : | NM_001025366 |
Protein Refseq : | NP_001020537 |
MIM : | 192240 |
Chromosome Location : | 6p12 |
Pathway : | Cytokine-cytokine receptor interaction; Focal adhesion; Pancreatic cancer; Renal cell carcinoma; VEGF signaling pathway; mTOR signaling pathway; Hemostasis; Signaling by VEGF. |
Function : | cell surface binding ;extracellular matrix binding; growth factor activity; growth factor activity; heparin binding; platelet-derived growth factor receptor binding; protein binding; protein homodimerization activity; vascular endothelial growth factor receptor binding. |
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Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (6)
Ask a questionStudies have shown that there is an association between the expression level of VEGFA protein and other biomarkers, for example, it can be associated with indicators such as tumor cell differentiation, metastatic capacity, and prognosis.
At present, a variety of drugs have been developed to target the VEGFA protein and its related signaling pathway, including inhibiting its expression and inhibiting its binding to receptors, etc., for the treatment of tumors and other vascular-related diseases.
VEGFA protein plays a key role in tumor angiogenesis, promoting tumor growth and metastasis by stimulating endothelial cell proliferation, migration, and vascular network formation.
The expression of VEGFA protein in different tissues and organs is different, and it is expressed in tumor tissue, cardiovascular system and other tissues and organs, and the expression level may be affected by many factors.
Studies have shown that the expression level of VEGFA protein is related to the degree of malignancy of the tumor, and the high expression of VEGFA protein often indicates that the tumor is more aggressive.
VEGFA protein plays an important role in cardiovascular disease by regulating endothelial cell function, promoting vascular repair and maintaining cardiovascular system homeostasis.
Customer Reviews (2)
Write a reviewVEGFA's catalytic activity is so strong that it can adapt even in the face of complex chemical reactions.
VEGFA they produced was highly active and the experimental effect was obvious.
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