Active Recombinant Monkey TNFRSF17 Protein, Fc-tagged, Alexa Fluor 647 conjugated
Cat.No. : | TNFRSF17-8829CAF647 |
Product Overview : | Alexa Fluor 647 conjugated recombinant Rhesus TNFRSF17(Met1-Ala53) fused with the Fc region of human IgG1 at C-terminal was expressed in HEK293. |
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Description : | Tumor necrosis factor receptor superfamily, member 17 (TNFRSF17), also known as B cell maturation antigen (BCMA) or CD269 antigen, is a member of the TNF-receptor superfamily. This receptor is preferentially expressed in mature B lymphocytes, and may be important for B cell development and autoimmune response. This receptor has been shown to specifically bind to the tumor necrosis factor (ligand) superfamily, member 13b (TNFSF13BBAFF), and to lead to NF-kappaB and MAPK8/JNK activation. TNFRSF17/BCMA/CD269 also binds to various TRAF family members, and thus may transduce signals for cell survival and proliferation. TNFRSF17/BCMA/CD269 is a receptor for TALL-1 and BCMA activates NF-kappaB through a TRAF5-, TRAF6-, NIK-, and IKK-dependent pathway. The identification of TNFRSF17 as a NF-kappaB-activating receptor for TALL-1 suggests molecular targets for drug development against certain immunodeficient or autoimmune diseases. TNFRSF17/BCMA is a target of donor B-cell immunity in patients with myeloma who respond to DLI. Antibody responses to cell-surface BCMA may contribute directly to tumor rejection in vivo. |
Source : | HEK293 |
Species : | Monkey |
Tag : | Fc |
Form : | Lyophilized |
Bio-activity : | Measured by its binding ability in a functional ELISA. Immobilized human BAFF at 10 μg/mL (100 μL/well) can bind Rhesus TNFRSF17-Fc, The EC50 of Rhesus TNFRSF17-Fc is 0.03-0.07 μg/mL. |
Molecular Mass : | 33 kDa |
Protein length : | Met1-Ala53, 294 |
N-terminal Sequence Analysis : | Met |
Endotoxin : | < 1.0 EU/ μg of the protein as determined by the LAL method. |
Purity : | > 95 % as determined by SDS-PAGE |
Characteristic : | Disulfide-linked homodimer Labeled with Alexa Fluor 647 via amines Excitation = 650 nm Emission = 668 nm |
Stability : | Samples are stable for up to 12 months from date of receipt at -70 centigrade. |
Storage : | Store it under sterile conditions at -20 to -80 centigrade. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. |
Storage Buffer : | Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. |
Shipping : | Shipped at ambient temperature. Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise. |
Gene Name : | TNFRSF17 TNF receptor superfamily member 17 [ Macaca mulatta ] |
Official Symbol : | TNFRSF17 |
Synonyms : | tumor necrosis factor receptor superfamily, member 17 |
Gene ID : | 712212 |
Products Types
◆ Recombinant Protein | ||
TNFRSF17-04H | Active Recombinant Human TNFRSF17 Protein, Fc-tagged, Atto 647N conjugated | +Inquiry |
Tnfrsf17-114M | Recombinant Mouse Tnfrsf17 Protein, His (Fc)-Avi-tagged | +Inquiry |
TNFRSF17-409H | Recombinant Human TNFRSF17 Protein (Met1-Ala54), His-Fc-tagged, Biotinylated | +Inquiry |
TNFRSF17-02H | Active Recombinant Human TNFRSF17 Protein, Fc-tagged, Alexa Fluor® 647 conjugated | +Inquiry |
TNFRSF17-2348H | Active Recombinant Human TNFRSF17(Met 1- Ala 54), Fc/His tagged | +Inquiry |
◆ Lysates | ||
TNFRSF17-2489HCL | Recombinant Human TNFRSF17 cell lysate | +Inquiry |
TNFRSF17-1489RCL | Recombinant Rat TNFRSF17 cell lysate | +Inquiry |
TNFRSF17-1253CCL | Recombinant Cynomolgus TNFRSF17 cell lysate | +Inquiry |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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