Active Recombinant Monkeys FAP Protein, His-tagged, FITC conjugated FAP-370CF

Active Recombinant Monkeys FAP Protein, His-tagged, FITC conjugated


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Active Recombinant Monkeys FAP Protein, His-tagged, FITC conjugated

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Cat.No. : FAP-370CF Optional Service: Optional requirements on this protein
Product Overview : FITC conjugated recombinant Cynomolgus FAP (XP_005573377.1) (Arg30-Asp760) was expressed with a polyhistidine tag at the N-terminus.
Description : Seprase, also known as 170 kDa melanoma membrane-bound gelatinase , Fibroblast activation protein alpha, Integral membrane serine protease and FAP, is a single-pass type II membrane protein which belongs to the peptidase S9B family. Seprase/FAP is found in cell surface lamellipodia, invadopodia and on shed vesicles. Seprase/FAP appears to act as a proteolytically active 170-kDa dimer, consisting of two 97-kDa subunits. It is a member of the group type II integral serine proteases, which includes dipeptidyl peptidase IV (DPPIV/CD26) and related type II transmembrane prolyl serine peptidases, which exert their mechanisms of action on the cell surface. Seprase/FAP col centigradealized with DPP4 in invadopodia and lamellipodia of migratory activated endothelial cells in collagenous matrix. Seprase/FAP col centigradealized with DPP4 on endothelial cells of capillary-like microvessels but not large vessels within invasive breast ductal carcinoma. DPP4 and seprase exhibit multiple functions due to their abilities to form complexes with each other and to interact with other membrane-ass centigradeiated molecules. In ass centigradeiation with DPP4, Seprase/FAP is involved in the pericellular proteolysis of the extracellular matrix (ECM), the migration and invasion of endothelial cells into the ECM. Seprase/FAP has a dual function in tumour progression. The proteolytic activity of Seprase has been shown to promote cell invasiveness towards the ECM and also to support tumour growth and proliferation. Seprase/FAP may have a role in tissue remodeling during development and wound healing, and may contribute to invasiveness in malignant cancers.
Source : HEK293
Species : Monkey
Tag : His
Form : Lyophilized
Bio-activity : Measured by its ability to convert the substrate benzyloxycarbonyl­Gly­Pro­7­amido­ 4­methylcoumarin (Z­GP­AMC) to Z­Gly­Pro and 7­amino­4­methylcoumarin (AMC). The specific activity is > 600 pmol/min/ μg.
Molecular Mass : 87 kDa
Protein length : Arg30-Asp760, 750
N-terminal Sequence Analysis : His
Endotoxin : < 1.0 EU/ μg protein as determined by the LAL method.
Purity : > 90 % as determined by SDS-PAGE
Characteristic : Disulfide-linked homodimer
Labeled with FITC via amines
Excitation source: 488 nm spectral line, argon-ion laser
Excitation Wavelength: 488 nm
Emission Wavelength: 535 nm
Storage : Samples are stable for up to twelve months from date of receipt at -70 centigrade. Store it under sterile conditions at -20 to -80 centigrade. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Storage Buffer : Lyophilized from sterile PBS, pH 7.4. Normally 5%-8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization.
Reconstitution : It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 μg/μL. Centrifuge the vial at 4 centigrade before opening to recover the entire contents.
Gene Name : FAP fibroblast activation protein alpha [ Macaca mulatta (Rhesus monkey) ]
Official Symbol : FAP
Synonyms : FAP; fibroblast activation protein alpha; prolyl endopeptidase FAP; EC; EC
Gene ID : 701541
mRNA Refseq : XM_015110238
Protein Refseq : XP_014965724
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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