Active Recombinant Monkeys FAP Protein, His-tagged, FITC conjugated
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March 21, 2023 | Add to Quote |
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Cat.No. : | FAP-370CF Optional Service: Optional requirements on this protein |
Product Overview : | FITC conjugated recombinant Cynomolgus FAP (XP_005573377.1) (Arg30-Asp760) was expressed with a polyhistidine tag at the N-terminus. |
Description : | Seprase, also known as 170 kDa melanoma membrane-bound gelatinase , Fibroblast activation protein alpha, Integral membrane serine protease and FAP, is a single-pass type II membrane protein which belongs to the peptidase S9B family. Seprase/FAP is found in cell surface lamellipodia, invadopodia and on shed vesicles. Seprase/FAP appears to act as a proteolytically active 170-kDa dimer, consisting of two 97-kDa subunits. It is a member of the group type II integral serine proteases, which includes dipeptidyl peptidase IV (DPPIV/CD26) and related type II transmembrane prolyl serine peptidases, which exert their mechanisms of action on the cell surface. Seprase/FAP col centigradealized with DPP4 in invadopodia and lamellipodia of migratory activated endothelial cells in collagenous matrix. Seprase/FAP col centigradealized with DPP4 on endothelial cells of capillary-like microvessels but not large vessels within invasive breast ductal carcinoma. DPP4 and seprase exhibit multiple functions due to their abilities to form complexes with each other and to interact with other membrane-ass centigradeiated molecules. In ass centigradeiation with DPP4, Seprase/FAP is involved in the pericellular proteolysis of the extracellular matrix (ECM), the migration and invasion of endothelial cells into the ECM. Seprase/FAP has a dual function in tumour progression. The proteolytic activity of Seprase has been shown to promote cell invasiveness towards the ECM and also to support tumour growth and proliferation. Seprase/FAP may have a role in tissue remodeling during development and wound healing, and may contribute to invasiveness in malignant cancers. |
Source : | HEK293 |
Species : | Monkey |
Tag : | His |
Form : | Lyophilized |
Bio-activity : | Measured by its ability to convert the substrate benzyloxycarbonylGlyPro7amido 4methylcoumarin (ZGPAMC) to ZGlyPro and 7amino4methylcoumarin (AMC). The specific activity is > 600 pmol/min/ μg. |
Molecular Mass : | 87 kDa |
Protein length : | Arg30-Asp760, 750 |
N-terminal Sequence Analysis : | His |
Endotoxin : | < 1.0 EU/ μg protein as determined by the LAL method. |
Purity : | > 90 % as determined by SDS-PAGE |
Characteristic : | Disulfide-linked homodimer Labeled with FITC via amines Excitation source: 488 nm spectral line, argon-ion laser Excitation Wavelength: 488 nm Emission Wavelength: 535 nm |
Storage : | Samples are stable for up to twelve months from date of receipt at -70 centigrade. Store it under sterile conditions at -20 to -80 centigrade. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. |
Storage Buffer : | Lyophilized from sterile PBS, pH 7.4. Normally 5%-8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. |
Reconstitution : | It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 μg/μL. Centrifuge the vial at 4 centigrade before opening to recover the entire contents. |
Gene Name : | FAP fibroblast activation protein alpha [ Macaca mulatta (Rhesus monkey) ] |
Official Symbol : | FAP |
Synonyms : | FAP; fibroblast activation protein alpha; prolyl endopeptidase FAP; EC 3.4.14.5; EC 3.4.21.26 |
Gene ID : | 701541 |
mRNA Refseq : | XM_015110238 |
Protein Refseq : | XP_014965724 |
◆ Recombinant Protein
FAP-3836H | Recombinant Human FAP Protein, GST-tagged | +Inquiry |
FAP-370C | Recombinant Cynomolgus FAP Protein, His-tagged | +Inquiry |
FAP-715H | Recombinant Human FAP Protein, His-tagged | +Inquiry |
Fap-716M | Recombinant Mouse Fap Protein, His-tagged | +Inquiry |
Fap-1018M | Recombinant Mouse Fap Protein, MYC/DDK-tagged | +Inquiry |
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◆ Lysates
FAP-1881HCL | Recombinant Human FAP cell lysate | +Inquiry |
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◆ Assay kits
Kit-1729 | FAP Assay Kit | +Inquiry |
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