Active Recombinant Mouse CD155 Protein, His-tagged

• Cat.No.: Pvr-65M
• Product Overview: CD155 protein dimer contains a CD155 extracellular domain (Uniprot# Q8K094) fused with a proprietary cis-dimer motif followed by a His tag at the C-terminus.

Specification

• Species: Mouse
• Source: HEK293T
• Tag: His
• Protein Length: 29-348 aa
• Description: Cluster of differentiation 155 (CD155) is a Type I transmembrane glycoprotein that belongs to the Nectin/Nectin-like family. CD155 is also known as Poliovirus Receptor (PVR), HVED, NECL5, Necl-5, PVS, TAGE4, and FLJ25946. CD155 protein consists of 3 extracellular immunoglobulin-like (Ig-like) domains (D1-D3), one transmembrane region, and a C-terminal cytoplasmic domain. CD155 is widely expressed on various cell types and often overexpressed on cancer cells. Upregulation of CD155 in several types of human cancers is associated with a poor prognosis. Although CD155 itself is not an immune checkpoint, it’s a ligand for checkpoint receptors like TIGIT (T-cell immunoreceptor with Ig and ITIM domains), CD226 (DNAM-1), and CD96. The interactions between CD155 and its receptors on immune cells modulate immune responses, such as T cells and natural killer (NK) cells. This makes CD155 a critical player in immune regulation and a promising target in checkpoint cancer therapies. Mouse CD155 shares 60-70% amino acid identity with human CD155. While homologous, there are species-specific differences in ligand binding and immune interactions.
• Molecular Mass: 86 kDa
• Homodimer/Heterodimer: Homodimer
• Purity: Greater than 90% dimer form as determined by SDS-PAGE under non-reducing condition
• Application: Verified Applications: ELISA for CD155-specific antibody and TIGIT ligand protein binding assays. SPR for CD155 and TIGIT ligand protein binding assays. Suggested Applications: BLI for CD155-specific antibody and TIGIT protein binding assays. Animal immunization, RUO.
• Storage: At -80 centigrade
• Storage Buffer: 0.22μm filtered PBS, pH 7.4
• Shipping: Frozen Dry Ice

Gene Information

• Gene ID: 52118
• Gene Name: Pvr poliovirus receptor [ Mus musculus (house mouse) ]
• Official Symbol: 52118
• Synonyms: Pvr; poliovirus receptor; PVS; mE4; HVED; Taa1; CD155; Tage4; necl-5; D7Ertd458e; 3830421F03Rik; poliovirus receptor; tumor-associated antigen 1
• mRNA Refseq: NM_027514
• Official Symbol 2: Pvr
• Gene ID 2: 52118
• Gene Name 2: Pvr poliovirus receptor [ Mus musculus (house mouse) ]
• mRNA Refseq 2: NM_027514
• Protein Refseq 2: NP_081790
• UniProt ID 2: Q8K094