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Active Recombinant Mouse CD200, MIgG2a Fc-tagged, mutant

Cat.No. : CD200-002M
Product Overview : The extracellular domain of mouse CD200 (NP_034948.3)(Gln31-Ser236) is fused to the N-terminus of the Fc portion of a mutant mouse IgG2a was expressed in CHO cell.
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Description : The protein encoded by this gene is a type-1 membrane glycoprotein, which contains two immunoglobulin domains, andthus belongs to the immunoglobulin superfamily. Studies of the related genes in mouse and rat suggest that thisgene may regulate myeloid cell activity and delivers an inhibitory signal for the macrophage lineage in diversetissues. Multiple alternatively spliced transcript variants that encode different isoforms have been found forthis gene
Source : CHO cells
Species : Mouse
Tag : MIgG2a Fc-tagged, mutant
Form : Lyophilized from 0.2μm-filtered solution in PBS.
Bio-activity : Measured by its binding ability in a functional ELISA.
Molecular Mass : 52 KDa
AA Sequence : Gln31-Ser236
Endotoxin : <0.06 eu/μg as determined by lal>
Purity : ≥98%, by SDS-PAGE under reducing conditions.
Stability : Stable for at least 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.
Reconstitution : Reconstitute at 100μg/ml in sterile PBS.
Warning : Avoid freeze/thaw cycles.
Protein length : Gln31-Ser236
Gene Name : Cd200 CD200 antigen [ Mus musculus ]
Official Symbol : CD200
Synonyms : CD200; CD200 antigen; OX-2 membrane glycoprotein; MRC OX-2 antigen; antigen identified by monoclonal MRC OX-2; OX2; Mox2;
Gene ID : 17470
mRNA Refseq : NM_010818
Protein Refseq : NP_034948
Pathway : Adaptive Immune System, organism-specific biosystem; Immune System, organism-specific biosystem; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell, organism-specific biosystem;
Function : protein binding;

Not For Human Consumption!

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Customer Reviews (3)

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Reviews
08/01/2022

    Swift protein sequencing, helps identify unknown proteins.

    05/04/2022

      Great protein crystallization services, key for structural biology.

      05/02/2019

        Invaluable protein-protein interaction assays, integral for research.

        Q&As (7)

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        How does CD200 contribute to the regulation of bone marrow and hematopoietic stem cell niches? 10/04/2022

        CD200 regulates bone marrow and hematopoietic environments, supporting stem cell maintenance and differentiation.

        How does CD200 influence tumor immune evasion and the tumor microenvironment in cancer? 07/10/2021

        CD200 contributes to immune evasion in cancers, affecting tumor progression and response to immunotherapy.

        What role does CD200 play in the suppression of inflammatory responses in autoimmune diseases? 04/06/2021

        CD200 plays a role in suppressing inflammatory responses, which is crucial in autoimmune disease management.

        What are the effects of CD200 dysregulation on tissue graft rejection and transplant tolerance? 02/09/2019

        Dysregulation of CD200 affects tissue graft rejection, influencing transplant tolerance and success.

        How do alterations in CD200 expression impact the aging process and age-related immune changes? 09/17/2018

        Changes in CD200 expression impact the aging immune system, affecting age-related immune regulation and function.

        What is the impact of CD200 expression on neuroinflammatory processes and neurodegenerative diseases? 03/20/2018

        CD200 expression influences neuroinflammatory processes, potentially impacting neurodegenerative diseases.

        How does CD200 interact with its receptor CD200R, and what are the implications for immune regulation? 03/18/2018

        CD200 interacts with CD200R to modulate immune responses, promoting immune tolerance and reducing inflammation.

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