Active Recombinant Mouse Ctla4 Protein, Fc-tagged

• Cat.No.: Ctla4-038M
• Product Overview: Purified recombinant protein of Mouse cytotoxic T-lymphocyte-associated protein 4 (Ctla4) (Ala37-Phe162) with a Fc tag was expressed in CHO cell.

Specification

• Species: Mouse
• Source: CHO
• Tag: Fc
• Description: This gene is a member of the immunoglobulin superfamily, and encodes a protein that functions as a negative regulator of T-cell responses. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.
• Bio-activity: The ED50 is 70 - 350 ng/ml, corresponding to a specific activity of 0.28-1.4 x 104 units/mg, determined by the dose dependent inhibition of IL-2 production induced by 0.5 µg/ml of CD80 on Jurkat cells
• Molecular Mass: 41 kDa
• Endotoxin: Less than 0.01 ng per µg protein as determined by the LAL method
• Purity: >95%, as determined by SDS-PAGE and Coomassie blue staining
• Stability: Unopened vial can be stored between 2 centigrade and 8 centigrade for up to 2 weeks, at -20 centigrade for up to 6 months, or at -70 centigrade or below until the expiration date. Aliquots can be stored between 2 centigrade and 8 centigrade for up to one week and stored at -20 centigrade or colder for up to 3 months. Avoid repeated freeze/thaw cycles.
• Storage: Store at -80 centigrade.
• Concentration: Protein formulated and vialed at >50 ug/mL in specified buffer
• Storage Buffer: 1 x PBS

Gene Information

• Gene Name: Ctla4 cytotoxic T-lymphocyte-associated protein 4 [ Mus musculus (house mouse) ]
• Official Symbol: Ctla4
• Synonyms: Ctla4; cytotoxic T-lymphocyte-associated protein 4; Cd152; Ly-56; Ctla-4; cytotoxic T-lymphocyte protein 4; CD152 antigen; cytotoxic T-lymphocyte-associated antigen 4
• Gene ID: 12477
• mRNA Refseq: NM_009843
• Protein Refseq: NP_033973
• UniProt ID: P09793