Active Recombinant Mouse Fc receptor-like 5, His-tagged

• Cat.No.: Fcrl5-503M
• Product Overview: RecombinantMouse Fcrl5 protein was expressed in Murine myeloma cellline. Met1-Ala496,with a C-terminal 6-His tag.

Specification

• Species: Mouse
• Source: Mammalian Cells
• Tag: His
• Protein Length: 1-496 a.a.
• Description: Fcrl5 is a 90-95kDa member of the FCRL family of proteins whose amino acid (aa) sequence isreminiscent of that for classical Fc receptors. FCLR molecules are type 1transmembrane proteins that contain from 3 to 9 immunoglobulin-like domains.They are differentially expressed within the B cell lineage, and can eitherpromote or inhibit B cell proliferation and activation. Mature mouse Fcrl5 consistsof a 470 aa extracellular domain (ECD), a 21 aa transmembrane segment, and a79 aa cytoplasmic region. The ECD contains five Iglike domains, while the cytoplasmicregion possesses one ITAM-like motif and one immunotyrosine inhibitory motif(ITIM).
• Form: Lyophilized from a0.2 um filtered solution in PBS.
• N-terminalSequence: Gln27 predicted
• MolecularWeight: 53.5 kDa
• Activity: Measuredby its ability to bind mouse IgG with an estimated KD < 400 nM.
• Endotoxin Level: <1.0EU per 1μg of the protein by the LAL method.
• SDS-PAGE: 65-80kDa, reducing conditions.
• Purity: >95%,by SDS-PAGE under reducing conditions and visualized by silver stain.
• Reconstitution: Reconstitute at 100μg/mLin PBS.
• Storage: Use amanual defrost freezer and avoid repeated freezethaw cycles. 12 months from date of receipt, -20 to -70°C as supplied.1 month, 2 to 8°C under sterile conditions after reconstitution. 3months, -20 to -70°C under sterile conditions after reconstitution.

Gene Information

• Gene Name: Fcrl5 Fc receptor-like 5 [ Musmusculus ]
• Official Symbol: Fcrl5
• Synonyms: Fcrl5; Fcreceptor-like 5; Fcrh3; mBXMH2; Fcreceptor-like protein 5; moFcRH3; fcR-like protein 5; BXMAS1-like protein 2;fc receptor homolog 3; Fc receptor-like protein 3
• Gene ID: 329693
• mRNA Refseq: NM_001113238
• Protein Refseq: NP_001106709
• UniProt ID: Q68SN8
• Chromosome Location: 3
• Pathway: T Cell ReceptorSignaling Pathway
• Function: molecular_function;receptor activity