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Active Recombinant Mouse Fibroblast Growth Factor 6

Cat.No. : Fgf6-527M
Product Overview : RecombinantMouse Fgf6 protein was expressed in E. coli. Pro39-Ile208.
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  • Gene Information
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Cat. No. : Fgf6-527M
Description : Fgf6 is a 25-28kDa member of the FGF family of heparin binding polypeptides which are potentregulators of cell proliferation, differentiation, and function. FGF proteinscontain a 120 amino acid (aa) core FGF domain that exhibits a β-trefoil structure.Mature mouse Fgf6 is a 171aa protein that shares 94% and 99% aa sequence identity with human and rat Fgf6, respectively.It binds and signals primarily through FGF R1c, 2c, and 4. Fgf6 functionsas a mitogen for fibroblasts, vascular endothelial cells, and prostatecarcinoma cells, and N-linked glycosylation is required for the fullmitogenic effect. Fgf6 expression is restricted to skeletalmuscle during development, although it can be upregulated in prostate cancerand Kaposi sarcoma.
Source : E. coli
Form : Lyophilizedfrom a 0.2 um filtered solution in MOPS, Ammonium Sulfate, EDTA, DTT with BSAas a carrier protein.
N-terminalSequence : Pro39
MolecularWeight : 18.8 kDa
Activity : Measuredin a cell proliferation assay using NR6R-3T3 mouse fibroblasts. The ED50 forthis effect is typically 0.2-1.0 ng/mL.
Endotoxin Level : <1.0EU per 1μg of the protein by the LAL method.
SDS-PAGE : 19 kDa,reducing conditions.
Purity : >90%,by SDS-PAGE under reducing conditions and visualized by silver stain.
Reconstitution : Reconstituteat 100μg/mL in PBS containing at least 0.1% human or bovine serum albumin.
Storage : Use amanual defrost freezer and avoid repeated freezethaw cycles. 12 months from date of receipt, -20 to -70°C as supplied.1 month, 2 to 8°C under sterile conditions after reconstitution. 3months, -20 to -70°C under sterile conditions after reconstitution.
Gene Name : Fgf6 fibroblast growth factor 6[ Mus musculus ]
Official Symbol : Fgf6
Synonyms : Fgf6; fibroblastgrowth factor 6; Fgf-6; HSTF-2; HST-2; HBGF-6; heparin-binding growthfactor 6; heparin secretory-transforming protein 2
Gene ID : 14177
mRNA Refseq : NM_010204
Protein Refseq : NP_034334
UniProt ID : P21658
Chromosome Location : 6
Pathway : Downstream signalingof activated FGFR; ESC Pluripotency Pathways; FGFR ligand binding andactivation; FGFR1 ligand binding and activation; FGFR1c ligand binding andactivation; FGFR2 ligand binding and activation; FGFR2c ligand binding andactivation; FGFR3 ligand binding and activation; FRS2-mediated cascade;IRS-mediated signalling; Insulin receptor signalling cascade; MAPK signalingpathway; Melanoma; PI-3K cascade; Pathways in cancer; Regulation of ActinCytoskeleton
Function : growth factoractivity

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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