Active Recombinant Mouse Flt1 Protein, Fc-tagged
Cat.No. : | Flt1-1785M |
Product Overview : | Recombinant mouse Flt1 protein (Ser27-Glu759) with mouse IgG2A (Glu98-Lys330) tag at C-terminus was expressed in Mouse myeloma cell line. |
Availability | July 26, 2024 |
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Description : | Biased expression in placenta adult (RPKM 35.7), lung adult (RPKM 11.8) and 11 other tissues. |
Source : | Mammalian cells |
Species : | Mouse |
Tag : | Fc |
Form : | Lyophilized |
Bio-activity : | Measured by its ability to inhibit the VEGF-dependent proliferation of HUVEC human umbilical vein endothelial cells. The ED50 for this effect is 5-30 ng/mL. |
Molecular Mass : | 109.6 kDa (monomer) |
Endotoxin : | <0.10 EU per 1 µg of the protein by the LAL method. |
Purity : | > 95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining |
Storage : | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 centigrade as supplied. 1 month, 2 to 8 centigrade under sterile conditions after reconstitution. 3 months, -20 to -70 centigrade under sterile conditions after reconstitution. |
Storage Buffer : | Lyophilized from a 0.2 µm filtered solution in PBS. |
Reconstitution : | Reconstitute at 100 µg/mL in PBS. |
Shipping : | The product is shipped at ambient temperature. |
Publication : |
Syndecan-1 and glycosaminoglycans in pre-eclamptic and normotensive pregnancies. (2017)
Soluble syndecan-1 and glycosaminoglycans in preeclamptic and normotensive pregnancies (2021)
Vascular damage and dysfunction in hypertensive emergencies (2017)
SFlt-1 Elevates Blood Pressure by Augmenting Endothelin-1-Mediated Vasoconstriction in Mice (2014)
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Gene Name : | Flt1 FMS-like tyrosine kinase 1 [ Mus musculus (house mouse) ] |
Official Symbol : | Flt1 |
Synonyms : | Flt1; FMS-like tyrosine kinase 1; Flt-1; sFlt1; VEGFR1; VEGFR-1; AI323757; vascular endothelial growth factor receptor 1; embryonic receptor kinase 2; tyrosine-protein kinase receptor FLT; vascular permeability factor receptor; EC 2.7.10.1 |
Gene ID : | 14254 |
mRNA Refseq : | NM_010228 |
Protein Refseq : | NP_034358 |
UniProt ID : | P35969 |
Products Types
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FLT1-3810H | Active Recombinant Human FLT1 Protein, His-Avi-tagged, Biotinylated | +Inquiry |
FLT1-372H | Recombinant Human FLT1 Protein, His-tagged | +Inquiry |
◆ Lysates | ||
FLT1-1909HCL | Recombinant Human FLT1 cell lysate | +Inquiry |
FLT1-1207RCL | Recombinant Rat FLT1 cell lysate | +Inquiry |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Customer Reviews (3)
Write a reviewthe FLT1 protein is an excellent choice for researchers due to its high quality, reliability, and the comprehensive technical support provided by the manufacturer.
The manufacturer of FLT1 protein provides excellent technical support, ensuring that researchers receive prompt assistance and guidance when encountering any challenges or difficulties.
Researchers can confidently incorporate FLT1 protein into their experiments, knowing that they have access to a reliable resource that will meet their experimental needs effectively.
Q&As (5)
Ask a questionElevated levels of soluble FLT1 have been associated with preeclampsia, a pregnancy complication. Soluble FLT1 acts as a decoy receptor, reducing the bioavailability of VEGF and contributing to vascular dysfunction.
FLT1 has been implicated in retinal diseases like diabetic retinopathy, where abnormal blood vessel growth can lead to vision impairment. Inhibiting FLT1 may help regulate angiogenesis in such conditions.
FLT1 expression is regulated by various factors, including VEGF itself, as well as hypoxia and inflammation. These factors influence the balance of angiogenic signaling.
Yes, elevated levels of soluble FLT1 have been investigated as potential biomarkers for conditions like preeclampsia, cancer, and certain cardiovascular diseases.
Yes, targeting FLT1 is a strategy for anti-angiogenic therapy. Inhibiting FLT1 can impede blood vessel formation, limiting the blood supply to tumors and potentially slowing their growth.
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