Active Recombinant Mouse IL15RA, MIgG2a Fc-tagged
Cat.No. : | IL15RA-1553M |
Product Overview : | The extracellular domain of mouse IL-15RA (NP_032384.1)(Gly33-Lys205) is fused to the N-terminus of the Fc region of a mouse IgG2a was expressed in CHO cell. |
- Specification
- Gene Information
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Description : | This gene encodes an immunoregulatory cytokine produced primarily by activated Th2 cells. This cytokine is involved in several stages of B-cell maturation and differentiation. It up-regulates CD23 and MHC class II expression, and promotes IgE isotype switching of B cells. This cytokine down-regulates macrophage activity, thereby inhibits the production of pro-inflammatory cytokines and chemokines. This cytokine is found to be critical to the pathogenesis of allergen-induced asthma but operates through mechanisms independent of IgE and eosinophils. This gene, IL3, IL5, IL4, and CSF2 form a cytokine gene cluster on chromosome 5q, with this gene particularly close to IL4. |
Source : | CHO cell |
Species : | Mouse |
Tag : | MIgG2a Fc-tagged |
Form : | Lyophilized from 0.2μm-filtered solution in PBS. |
Bio-activity : | Measured by its ability to block human IL-15-induced proliferation of CTLL2 mouse cytotoxic T cells. |
Molecular Mass : | 45KDa (monomer) |
AA Sequence : | Gly33-Lys205 |
Endotoxin : | <0.06 eu/μg as determined by lal test.>0.06> |
Purity : | >98%, by SDS-PAGE under reducing conditions. |
Stability : | Stable for at least 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C. |
Reconstitution : | Reconstitute at 100μg/ml in sterile PBS. |
Warning : | Avoid freeze/thaw cycles. |
Gene Name : | Il15ra interleukin 15 receptor, alpha chain [ Mus musculus ] |
Official Symbol : | IL15RA |
Synonyms : | IL15RA; interleukin 15 receptor, alpha chain; interleukin-15 receptor subunit alpha; IL-15RA; IL-15R-alpha; IL-15 receptor subunit alpha; AA690181; |
Gene ID : | 16169 |
mRNA Refseq : | NM_008358 |
Protein Refseq : | NP_032384 |
Pathway : | Cytokine-cytokine receptor interaction, organism-specific biosystem; Cytokine-cytokine receptor interaction, conserved biosystem; HTLV-I infection, organism-specific biosystem; HTLV-I infection, conserved biosystem; Intestinal immune network for IgA production, organism-specific biosystem; Intestinal immune network for IgA production, conserved biosystem; Jak-STAT signaling pathway, organism-specific biosystem; |
Function : | receptor activity; |
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◆ Lysates | ||
IL15RA-5246HCL | Recombinant Human IL15RA 293 Cell Lysate | +Inquiry |
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Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (10)
Ask a questionImmunoprecipitation validates IL15RA's binding to IL2RB in cells.
CRISPR/Cas9 technology aids in generating IL15RA knockout models.
Approaches unravel IL15RA's implication in autoimmune disease mechanisms.
Methods discern IL15RA's distinct roles in innate and adaptive immunity.
RT-PCR and Western blotting assess IL15RA isoform expression patterns.
Binding affinity of IL15RA to IL15 quantified through surface plasmon resonance.
Proliferation assays investigate IL15RA's contribution to immune cell growth.
IL15RA's interaction with JAK/STAT pathways probed using immunoblotting.
siRNA knockdown studies unveil IL15RA's impact on downstream signaling.
FRET assays employed to elucidate IL15RA dimerization kinetics.
Customer Reviews (3)
Write a reviewEffective in T-cell assays.
High purity levels.
Consistent receptor binding.
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