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Active Recombinant Mouse IL15RA, MIgG2a Fc-tagged

Cat.No. : IL15RA-1553M
Product Overview : The extracellular domain of mouse IL-15RA (NP_032384.1)(Gly33-Lys205) is fused to the N-terminus of the Fc region of a mouse IgG2a was expressed in CHO cell.
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  • Gene Information
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Description : This gene encodes an immunoregulatory cytokine produced primarily by activated Th2 cells. This cytokine is involved in several stages of B-cell maturation and differentiation. It up-regulates CD23 and MHC class II expression, and promotes IgE isotype switching of B cells. This cytokine down-regulates macrophage activity, thereby inhibits the production of pro-inflammatory cytokines and chemokines. This cytokine is found to be critical to the pathogenesis of allergen-induced asthma but operates through mechanisms independent of IgE and eosinophils. This gene, IL3, IL5, IL4, and CSF2 form a cytokine gene cluster on chromosome 5q, with this gene particularly close to IL4.
Source : CHO cell
Species : Mouse
Tag : MIgG2a Fc-tagged
Form : Lyophilized from 0.2μm-filtered solution in PBS.
Bio-activity : Measured by its ability to block human IL-15-induced proliferation of CTLL2 mouse cytotoxic T cells.
Molecular Mass : 45KDa (monomer)
AA Sequence : Gly33-Lys205
Endotoxin : <0.06 eu/μg as determined by lal test.>
Purity : >98%, by SDS-PAGE under reducing conditions.
Stability : Stable for at least 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.
Reconstitution : Reconstitute at 100μg/ml in sterile PBS.
Warning : Avoid freeze/thaw cycles.
Gene Name : Il15ra interleukin 15 receptor, alpha chain [ Mus musculus ]
Official Symbol : IL15RA
Synonyms : IL15RA; interleukin 15 receptor, alpha chain; interleukin-15 receptor subunit alpha; IL-15RA; IL-15R-alpha; IL-15 receptor subunit alpha; AA690181;
Gene ID : 16169
mRNA Refseq : NM_008358
Protein Refseq : NP_032384
Pathway : Cytokine-cytokine receptor interaction, organism-specific biosystem; Cytokine-cytokine receptor interaction, conserved biosystem; HTLV-I infection, organism-specific biosystem; HTLV-I infection, conserved biosystem; Intestinal immune network for IgA production, organism-specific biosystem; Intestinal immune network for IgA production, conserved biosystem; Jak-STAT signaling pathway, organism-specific biosystem;
Function : receptor activity;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (10)

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How does immunoprecipitation validate IL15RA's association with IL2RB? 10/23/2022

Immunoprecipitation validates IL15RA's binding to IL2RB in cells.

What are the applications of CRISPR/Cas9 in studying IL15RA knockout models? 07/08/2021

CRISPR/Cas9 technology aids in generating IL15RA knockout models.

Could you explain the approaches to investigate IL15RA's role in autoimmune diseases? 03/15/2021

Approaches unravel IL15RA's implication in autoimmune disease mechanisms.

What experimental strategies differentiate IL15RA's role in innate and adaptive immunity? 06/17/2020

Methods discern IL15RA's distinct roles in innate and adaptive immunity.

What techniques characterize IL15RA isoform expression in tissues? 06/14/2020

RT-PCR and Western blotting assess IL15RA isoform expression patterns.

How is IL15RA's binding affinity to IL15 measured in vitro? 01/05/2019

Binding affinity of IL15RA to IL15 quantified through surface plasmon resonance.

What methods explore IL15RA's involvement in immune cell proliferation? 11/12/2017

Proliferation assays investigate IL15RA's contribution to immune cell growth.

How is IL15RA's interaction with JAK/STAT pathways analyzed? 11/11/2017

IL15RA's interaction with JAK/STAT pathways probed using immunoblotting.

How do siRNA knockdown experiments reveal IL15RA's role in signaling? 04/20/2017

siRNA knockdown studies unveil IL15RA's impact on downstream signaling.

Can you detail the use of FRET assays to study IL15RA dimerization? 01/09/2017

FRET assays employed to elucidate IL15RA dimerization kinetics.

Customer Reviews (3)

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Reviews
10/29/2020

    Effective in T-cell assays.

    03/10/2018

      High purity levels.

      05/28/2017

        Consistent receptor binding.

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