Active Recombinant Mouse Il6 Protein, His-Tagged
Cat.No. : | Il6-01M |
Product Overview : | Recombinant mouse Il6 Protein, His-tagged was expressed in E. coli cell |
- Specification
- Gene Information
- Related Products
Description : | Interleukin 6 (IL-6) is an interleukin that acts as both a pro-inflammatory cytokine and an anti-inflammatory myokine. In humans, it is encoded by the IL6 gene. In addition, osteoblasts secrete IL-6 to stimulate osteoclast formation. Smooth muscle cells in the tunica media of many blood vessels also produce IL-6 as a pro-inflammatory cytokine. IL-6's role as an anti-inflammatory myokine is mediated through its inhibitory effects on TNF-alpha and IL-1, and activation of IL-1ra and IL-10. |
Source : | Escherichia coli |
Species : | Mouse |
Tag : | His |
Form : | Lyophilized powder |
AA Sequence : | MFPTSQVRRGDFTEDTTPNRPVYTT SQVGGLITHVLWEIVEMRKELCNGN SDCMNNDDALAENNLKLPEIQRNDG CYQTGYNQEICLLKIS SGLLEYHSYLEYMKNNLKDNKKDKA RVLQRDTETLIHIFNQEVKDLHKIV LPTPISNALLTDKLESQKEWLRTKT IQFILKSLEEFLKVTLRSTRQ T with polyhistidine tag at the C-terminus |
Endotoxin : | <0.1 EU per 1 μg of the protein by the LAL method. |
Bio-activity : | Measure by its ability to induce proliferation in 7TD1 cells. The ED50 for this effect is <0.01 ng/mL. The specific activity of recombinant mouse IL-6 is approximately >1x 10^8 IU/mg. |
Purity : | >98% as determined by SDS-PAGE. Ni-NTA chromatography |
Storage Buffer : | The protein was lyophilized from a solution containing 1X PBS, pH 8.0. |
Reconstitution : | It is recommended to reconstitute the lyophilized protein in sterile H2O to a concentration not less than 100 μg/mL and incubate the stock solution for at least 20 min to ensure sufficient re-dissolved. |
Storage : | Lyophilized protein should be stored at -20°C. Upon reconstitution, protein aliquots should be stored at -20°C or -80°C. |
Notes : | Please use within one month after protein reconstitution. |
Gene Name : | Il6 interleukin 6 [ Mus musculus (house mouse) ] |
Official Symbol : | Il6 |
Synonyms : | Il-6 |
Gene ID : | 16193 |
mRNA Refseq : | NM_001314054.1 |
Protein Refseq : | NP_001300983.1 |
UniProt ID : | P08505 |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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