Active Recombinant Mouse Interleukin 17F
|Product Overview :||Recombinant Mouse IL-17F produced in E.coli is a homodimeric, non-glycosylated polypeptide chain containing a total of 133 amino acids and having a molecular mass of 14.9 kDa.|
- Gene Information
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|Cat. No. :||Il17f-497M|
|Description :||Interleukin-17 (IL-17 or IL-17A) is the founding member of a group of cytokines called the IL-17 family. Interleukin 17 is a cytokine that acts as a potent mediator in delayed ?C type reactions by increasing chemokine production in various tissues to recruit monocytes and neutrophils to the site of inflammation, similar to Interferon gamma. IL- 17 is produced by T helper cells and is induced by IL ?C 23 which results in destructive tissue damage in delayed ?C type reactions.|
|Form :||Lyophilized with no additives.|
|Purity :||Purity Greater than 98% as determined by: Analysis by RP-HPLC. Reducing and non-reducing SDS-PAGE.|
|Bio-activity :||IL-17F is fully bioactive when compared to standard. The ED50 as determined by the dose-dependant induction of IL-6 in NHDF is 1.94 ng/ml.|
|Physical Appearance :||Sterile Filtered white lyophilized (freeze-dried) powder.|
|Solubility :||It is recommended to reconstitute the lyophilized product with sterile water at a concentration of 0.1 mg/ml, which can be further diluted into other aqueous solutions.|
|Purity Greater than 98% as determined by :||Analysis by RP-HPLC. Reducing and non-reducing SDS-PAGE.|
|Protein Content determined by :||UV spectroscopy at 280 nm. Analysis by RP-HPLC calibrated against a known standard. Quantitation on SDS-PAGE against a known standard.|
|Endotoxin Level :||Endotoxin level is <0.01ng/ug or <0.1EU/ug.|
|Amino acid sequence :||MRKNPKAGVP ALQKAGNCPP LEDNTVRVDI RIFNQNQGIS VPREFQNRSS SPWDYNITRD PHRFPSEIAEAQCRHSGCIN AQGQEDSTMN SVAIQQEILV LRREPQGCSN SFRLEKMLLK VGCTCVKPIV HQAA|
|Storage :||Lyophilized product is very stable at -20 degrees. Reconstituted material should be aliquoted and frozen at -20. It is recommended to add a carrier protein (0.1% HSA or BSA) for long term storage.|
|Gene Name :||Il17f interleukin 17F [ Mus musculus ]|
|Official Symbol :||Il17f|
|Synonyms :||Il17f; interleukin 17F; C87042; IL-17F|
|Gene ID :||257630|
|mRNA Refseq :||NM_145856|
|Protein Refseq :||NP_665855|
|UniProt ID :||Q7TNI7|
|Chromosome Location :||1 A4|
|Function :||cytokine activity|
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Q&As (10)Ask a question
Tumor xenografts, immune cell infiltration analysis, and therapeutic antibody testing assess IL17F's role in cancer.
Neutrophil chemotaxis assays, in vivo neutrophil tracking, and immune cell activation analysis explore IL17F's impact on neutrophil functions.
Genetic knockout models, functional assays, and gene expression analyses distinguish IL17F's unique roles.
Microbiota composition analysis, germ-free models, and immune cell profiling investigate IL17F-microbiota interactions.
Animal disease models, patient samples, and immunological assays elucidate IL17F's contribution to autoimmune diseases.
Co-immunoprecipitation, fluorescence resonance energy transfer (FRET), and pathway-specific assays elucidate IL17F's heterodimerization and signaling.
Comparative cytokine profiling, inflammatory assays, and pathway analysis dissect IL17F's interplay with other immune mediators.
Allergen challenges, inflammatory disease models, and gene expression profiling probe IL17F's involvement in chronic conditions.
Epithelial barrier permeability assays, tissue section analysis, and cell culture models study IL17F's effects on barrier integrity.
Wound healing assays, tissue regeneration models, and histological analyses examine IL17F's effects on tissue repair.
Customer Reviews (3)Write a review
High specificity. -
Good for receptor studies. -
Potent in anti-bacterial assays. -
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