Active Recombinant Mouse Interleukin 3 Receptor, Alpha Chain, Fc-tagged

• Cat.No.: Il3ra-5661M
• Product Overview: RecombinantMouse Il3ra protein was expressed in Spodopterafrugiperdawith the Fc part of Human IgG1 Pro100-Lys330 (C-terminus) and MouseIl3ra Ser17-Lys331 (N-terminus).

Specification

• Cat. No.: Il3ra-5661M
• Description: Il3ra isa pleiotropic cytokine produced primarily by activated T cells or mast cells.Il3ra stimulates the proliferation and differentiation of hemopoietic cellsincluding the pluripotent hematopoietic stem cells as well as various lineage-committedcells. The biological effects of Il3ra on the various cell types are mediatedby the binding of Il3ra to specific cell surface receptor complexes. Thefunctional high-affinity IL-3 receptor is a heterodimer consisting of aligand binding α subunit and the β subunit. The α subunit alone binds Il3rawith low affinity.
• Source: Spodopterafrugiperda, Sf 21 (baculovirus)-derived.
• Form: Lyophilizedfrom a 0.2 μm filtered solution in PBS.
• N-terminalSequence: Ser17
• MolecularWeight: 61.0 kDa (monomer)
• Activity: Measuredby its ability to inhibit the IL-3-induced proliferation of NFS-60 mouse myeloidcells. The ED50 for this effect is typically 0.03-0.15 μg/mL in the presenceof 2.5 μg/mL Recombinant Mouse IL-3 Rβ Fc Chimera and 2 ng/mL of RecombinantMouse Il3ra.
• Endotoxin Level: <1.0EU per 1μg of the protein by the LAL method.
• SDS-PAGE: 70-80kDa, reducing conditions.
• Purity: >90%,by SDS-PAGE under reducing conditions and visualized by silver stain.
• Reconstitution: 100 μg/mLin sterile PBS
• Storage: Use amanual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70°C as supplied. 1month, 2 to 8°C under sterile conditions after reconstitution. 3 months, -20 to-70°C under sterile conditions after reconstitution.

Gene Information

• Gene Name: Il3ra interleukin 3 receptor,alpha chain [ Mus musculus ]
• Official Symbol: Il3ra
• Synonyms: Il3ra; interleukin 3receptor, alpha chain; CD123; SUT-1; CDw123;interleukin-3 receptor subunit alpha; IL-3RA; IL-3R-alpha; Il-3 alpha subunit;IL-3R subunit alpha; IL-3 receptor alpha chain; IL-3 receptor subunit alpha;IL-3 receptor alpha SP2 isoform; interleukin-3 receptor class II alpha chain
• Gene ID: 16188
• mRNA Refseq: NM_008369
• Protein Refseq: NP_032395
• UniProt ID: P26952
• Chromosome Location: 14
• Pathway: Apoptosis;Cytokine-cytokine receptor interaction; Hematopoietic cell lineage; IL-3Signaling Pathway; Jak-STAT signaling pathway
• Function: cytokine receptoractivity; receptor activity

Reviews

07/24/2022

In special environment, good stability.

05/25/2022

Good crystallization property and good effect.

06/29/2021

Has the expected biological activity, such as enzyme activity and receptor binding activity, and so on.

Q&As

Can Il3ra be personalized?

The feasibility of personalized therapy depends on the specific disease type and patient situation, and more research is needed to determine the application of personalized therapy to Il3ra.

Does Il3ra have clinical application prospects? What are the prospects?

Il3ra has certain promise in clinical application, especially in the treatment of immune-related diseases.

What is the action mechanism of Il3ra?

Regulates the proliferation and differentiation of immune cells by binding to its interacting cytokine IL-3, and plays a role in regulating the function of the immune system.

How is the clinical trial of Il3ra progressing?

Clinical trials of recombinant Il3ra have been conducted in different disease areas. At present, some early trials show its potential in the treatment of certain diseases, but more research is needed to verify its efficacy and safety.

What is the specific effect of Il3ra on the immune system?

The Il3ra can regulate the proliferation and differentiation of different types of immune cells in the immune system, thus affecting the function of the immune system.

Does Il3ra have side effects?

Il3ra is generally well tolerated, but some minor side effects such as headache and nausea may occur. Serious side effects are rare.