Active Recombinant Mouse Msln Protein, His-tagged

Cat.No. : Msln-4191M
Product Overview : Purified recombinant protein of Mouse mesothelin (Msln) with a C-His tag was expressed in HEK293.
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Description : Membrane-anchored forms may play a role in cellular adhesion.
Source : HEK293
Species : Mouse
Tag : His
Bio-activity : The ED50 is 1.5 - 7.5 μg/ml, corresponding to a specific activity of 0.13-0.66 × 10^3 units/mg, determined by the dose dependent binding to CA125/MUC16 using a functional ELISA.
Molecular Mass : 32.9 kDa
Protein length : Asp298-Gly582
Endotoxin : Less than 0.01 ng/μg protein as determined by the LAL method
Purity : > 97%, as determined by Coomassie stained SDS-PAGE.
Stability : Unopened vial can be stored between 2 and 8 centigrade for up to 2 weeks, at -20 centigrade for up to 6 months, or at -70 centigrade or below until the expiration date. Aliquots can be stored between 2 and 8 centigrade for up to one week and stored at -20 centigrade or colder for up to 3 months. Avoid repeated freeze/thaw cycles.
Storage : Store at -80 centigrade.
Concentration : Protein formulated and vialed at >50 μg/mL in specified buffer
Storage Buffer : 1 x PBS, pH 7.2
Gene Name : Msln mesothelin [ Mus musculus (house mouse) ]
Official Symbol : Msln
Synonyms : MSLN; mesothelin; megakaryocyte potentiating factor; pre-pro-megakaryocyte-potentiating factor; MPF
Gene ID : 56047
mRNA Refseq : NM_018857
Protein Refseq : NP_061345
UniProt ID : Q61468

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (7)

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What is the primary role of MSLN in normal tissues? 12/07/2022

MSLN is normally expressed in mesothelial cells, playing a role in cell adhesion.

How is MSLN expression altered in cancerous cells? 03/19/2022

In cancer, MSLN expression is significantly upregulated.

In which types of cancer is MSLN overexpressed? 03/28/2021

MSLN is overexpressed in mesothelioma, ovarian, and pancreatic cancers.

Are there any therapeutic strategies targeting MSLN in cancer treatment? 02/25/2020

Therapies targeting MSLN include antibody-drug conjugates and CAR-T cell therapies.

How can MSLN levels be detected and measured in clinical settings? 10/07/2019

MSLN levels can be assessed through immunohistochemistry and serum biomarker tests.

What is the prognostic significance of MSLN overexpression in cancer patients? 11/23/2018

MSLN overexpression is often associated with poor prognosis in cancer patients.

How does MSLN contribute to cancer progression and metastasis? 11/07/2018

MSLN promotes tumor cell proliferation, invasion, and resistance to apoptosis.

Customer Reviews (3)

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Reviews
05/22/2022

    Very satisfied, great product.

    03/06/2022

      Product is high-quality.

      09/30/2021

        Excellent for experiments, reliable.

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