Active Recombinant Mouse Msln Protein, His-tagged

• Cat.No.: Msln-4191M
• Product Overview: Purified recombinant protein of Mouse mesothelin (Msln) with a C-His tag was expressed in HEK293.

Specification

• Description: Membrane-anchored forms may play a role in cellular adhesion.
• Source: HEK293
• Species: Mouse
• Tag: His
• Bio-activity: The ED50 is 1.5 - 7.5 μg/ml, corresponding to a specific activity of 0.13-0.66 × 10^3 units/mg, determined by the dose dependent binding to CA125/MUC16 using a functional ELISA.
• Molecular Mass: 32.9 kDa
• Protein length: Asp298-Gly582
• Endotoxin: Less than 0.01 ng/μg protein as determined by the LAL method
• Purity: > 97%, as determined by Coomassie stained SDS-PAGE.
• Stability: Unopened vial can be stored between 2 and 8 centigrade for up to 2 weeks, at -20 centigrade for up to 6 months, or at -70 centigrade or below until the expiration date. Aliquots can be stored between 2 and 8 centigrade for up to one week and stored at -20 centigrade or colder for up to 3 months. Avoid repeated freeze/thaw cycles.
• Storage: Store at -80 centigrade.
• Concentration: Protein formulated and vialed at >50 μg/mL in specified buffer
• Storage Buffer: 1 x PBS, pH 7.2

Gene Information

• Gene Name: Msln mesothelin [ Mus musculus (house mouse) ]
• Official Symbol: Msln
• Synonyms: MSLN; mesothelin; megakaryocyte potentiating factor; pre-pro-megakaryocyte-potentiating factor; MPF
• Gene ID: 56047
• mRNA Refseq: NM_018857
• Protein Refseq: NP_061345
• UniProt ID: Q61468

Reviews

05/22/2022

Very satisfied, great product.

03/06/2022

Product is high-quality.

09/30/2021

Excellent for experiments, reliable.

Q&As

What is the primary role of MSLN in normal tissues?

MSLN is normally expressed in mesothelial cells, playing a role in cell adhesion.

How is MSLN expression altered in cancerous cells?

In cancer, MSLN expression is significantly upregulated.

In which types of cancer is MSLN overexpressed?

MSLN is overexpressed in mesothelioma, ovarian, and pancreatic cancers.

Are there any therapeutic strategies targeting MSLN in cancer treatment?

Therapies targeting MSLN include antibody-drug conjugates and CAR-T cell therapies.

How can MSLN levels be detected and measured in clinical settings?

MSLN levels can be assessed through immunohistochemistry and serum biomarker tests.

What is the prognostic significance of MSLN overexpression in cancer patients?

MSLN overexpression is often associated with poor prognosis in cancer patients.

How does MSLN contribute to cancer progression and metastasis?

MSLN promotes tumor cell proliferation, invasion, and resistance to apoptosis.