Active Recombinant Mouse Nrg4 Protein, GST-tagged
Cat.No. : | Nrg4-01M |
Product Overview : | Recombinant Mouse Neuregulin-4 (aa 1-53) with a GST-tag at the N-terminus was expressed in E. coli. |
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Description : | Neuregulin-4 (Nrg4) belongs to a small family of EGF-like (EGFL) domain-containing proteins that are synthesized as transmembrane precursors and undergo proteolytic cleavage. The EGF-like domain (aa 5-46) of Nrg4 (aa 1-53) directly binds to the receptors ErbB3 and 4. Nrg4 is a cold induced adipokine, highly expressed in adipose tissues and enriched in brown fat. It is increased during brown adipocyte differentiation and reduced in rodent and human obesity. It promotes neurite outgrowth and protects against diet-induced insulin resistance and hepatic steatosis through attenuating hepatic lipogenic signaling. This hepatic effect of Nrg4 is mediated by ErbB3 and ErbB4 signaling that negatively regulates de novo lipogenesis mediated by LXR and SREBP1c. This effect of Nrg4 on fatty liver and insulin resistance could lead to the development of Nrg4 as an effective therapeutic biological for the treatment of NAFLD and type 2 diabetes. |
Source : | E. coli |
Species : | Mouse |
Tag : | GST |
Bio-activity : | Binds to mouse and human receptor tyrosine-protein kinase ErbB4. |
Molecular Mass : | ~32 kDa |
Protein length : | 1-53 |
Endotoxin : | < 0.01 EU/μg purified protein (LAL test). |
Purity : | ≥ 95% by SDS-PAGE |
Stability : | Stable for at least 6 months after receipt when stored at -20 centigrade. Working aliquots are stable for up to 3 months when stored at -20 centigrade. |
Storage : | Short Term Storage: +4 centigrade Long Term Storage: -20 centigrade |
Concentration : | 0.1 mg/mL after reconstitution. |
Storage Buffer : | Lyophilized. Contains PBS. |
Reconstitution : | Reconstitute with 100 μL sterile water. |
Shipping : | Blue Ice. |
Gene Name : | Nrg4 neuregulin 4 [ Mus musculus (house mouse) ] |
Official Symbol : | Nrg4 |
Synonyms : | Nrg4; neuregulin 4; AI552600; pro-neuregulin-4, membrane-bound isoform; pro-NRG4 |
Gene ID : | 83961 |
mRNA Refseq : | NM_032002 |
Protein Refseq : | NP_114391 |
UniProt ID : | Q9WTX4 |
Products Types
◆ Recombinant Protein | ||
NRG4-167 | Recombinant NRG4 Protein, GST-tagged | +Inquiry |
Nrg4-1861R | Recombinant Rat Nrg4 Protein, His-tagged | +Inquiry |
NRG4-365H | Recombinant Human NRG4 Protein, His/GST-tagged | +Inquiry |
Nrg4-366M | Recombinant Mouse Nrg4 Protein, His-tagged | +Inquiry |
NRG4-3679H | Recombinant Human NRG4 Protein, His (Fc)-Avi-tagged | +Inquiry |
◆ Lysates | ||
NRG4-1221HCL | Recombinant Human NRG4 cell lysate | +Inquiry |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Customer Reviews (3)
Write a reviewNRG4 had the intended biological effect in the experiment.
The experimental results using NRG4 are accurate and reliable, and the data are scientific.
NRG4's products have been widely recognized and applied in the research of related fields.
Q&As (6)
Ask a questionThe function of NRG4 can be studied through overexpression techniques, such as the use of gene transfection or viral transduction. These techniques can increase the expression level of NRG4 to observe its effects on cell growth, differentiation, and survival, among other things.
It has a variety of roles in tissues such as the heart, nerves, and muscles, including promoting cell growth, differentiation, and survival, as well as regulating synaptic plasticity and nerve signaling.
In the heart, NRG4 can promote cardiomyocyte growth and survival, maintain cardiomyocyte electrophysiological properties, and regulate cardiac rhythms.
Immunohistochemistry, western blotting, and real-time PCR can be used to detect NRG4 expression levels in tissues and cells. These techniques can be used to assess NRG4 expression in different tissues and cells.
NRG4 activates receptor phosphorylation by interacting with its receptors ErbB3 and ErbB4, which in turn triggers intracellular signaling pathways.
The interaction between NRG4 and other proteins is regulated by a variety of mechanisms, including through the formation of complexes, through interaction motifs at the interface of protein interactions, and by regulating conformational changes of proteins. These interactions can be modulated to achieve specific physiological functions.
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