Active Recombinant Mouse Pdcd1, MIgG2a Fc-tagged

• Cat.No.: Pdcd1-041M
• Product Overview: The extracellular domain of mouse CD279 [PD-1] (NP_032824.1) (Glu26-Met169) is fused to the Fc region of mouse lg2a.

Specification

• Description: This gene encodes a cell surface membrane protein of the immunoglobulin superfamily. This protein is expressed inpro-B-cells and is thought to play a role in their differentiation. In mice, expression of this gene is inducedin the thymus when anti-CD3 antibodies are injected and large numbers of thymocytes undergo apoptosis. Micedeficient for this gene bred on a BALB/c background developed dilated cardiomyopathy and died from congestiveheart failure. These studies suggest that this gene product may also be important in T cell function andcontribute to the prevention of autoimmune diseases.
• Source: CHO cells
• Species: Mouse
• Tag: MIgG2a Fc-tagged
• Form: Lyophilized from 0.2μm-filtered solution in PBS.
• Bio-activity: Measured by its binding ability in a functional ELISA.
• Molecular Mass: 43 KDa (monomer)
• AA Sequence: Glu26-Met169
• Endotoxin: <0.06 eu/μg as determined by lal test.>
• Purity: >98%, by SDS-PAGE under reducing conditions.
• Stability: Stable for at least 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.
• Reconstitution: Reconstitute at 100μg/ml in sterile PBS.
• Warning: Avoid freeze/thaw cycles.

Gene Information

• Gene Name: Pdcd1 programmed cell death 1 [ Mus musculus ]
• Official Symbol: Pdcd1
• Synonyms: PDCD1; programmed cell death 1; programmed cell death protein 1; mPD-1; protein PD-1; PD-1; Pdc1; Ly101
• Gene ID: 18566
• mRNA Refseq: NM_008798
• Protein Refseq: NP_032824
• Pathway: Adaptive Immune System, organism-specific biosystem; Cell adhesion molecules (CAMs), organism-specific biosystem; Cell adhesion molecules (CAMs), conserved biosystem; Costimulation by the CD28 family, organism-specific biosystem; Immune System, organism-specific biosystem; PD-1 signaling, organism-specific biosystem; T cell receptor signaling pathway, organism-specific biosystem
• Function: protein binding