| Species : |
Mouse |
| Source : |
Insect Cells |
| Tag : |
GST |
| Protein Length : |
1-441 aa |
| Description : |
Enables chloride ion binding activity; ion channel inhibitor activity; and protein serine/threonine kinase activity. Involved in several processes, including ERK1 and ERK2 cascade; metal ion transport; and regulation of protein kinase activity. Acts upstream of or within chloride transport; negative regulation of pancreatic juice secretion; and protein localization. Located in bicellular tight junction and cytoplasm. Part of protein-containing complex. Is active in cell body. Is expressed in several structures, including alimentary system; metanephros; metatarsal bone; sensory organ; and turbinate bone primordium. Used to study Gitelman syndrome and pseudohypoaldosteronism. Human ortholog(s) of this gene implicated in hypertension and pseudohypoaldosteronism. Orthologous to human WNK4 (WNK lysine deficient protein kinase 4). |
| Form : |
50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol. |
| Bio-activity : |
Specific Activity: 1.5 nmol/min/mg |
| Molecular Mass : |
~86 kDa |
| Purity : |
>85% |
| Applications : |
WB, Kinase Assay |
| Storage : |
Store product at -70 centigrade. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles. 1yr at -70 centigrade from date of shipment. |
| Concentration : |
0.1 μg/μL |
| Shipping : |
Dry ice |
