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Active Recombinant Porcine IL2 Protein

Cat.No. : IL2-83P
Product Overview : Recombinant Porcine IL2 was expressed in E. coli.
  • Specification
  • Gene Information
  • Related Products
Description : IL2 is a secreted cytokine that is important for the proliferation of T and B lymphocytes. The receptor of this cytokine is a heterotrimeric protein complex whose gamma chain is also shared by interleukin 4 (IL4) and interleukin 7 (IL7). The expression of this gene in mature thymocytes is monoallelic, which represents an unusual regulatory mode for controlling the precise expression of a single gene. The targeted disruption of a similar gene in mice leads to ulcerative colitis-like disease, which suggests an essential role of this gene in the immune response to antigenic stimuli.
Source : E. coli
Species : Porcine
Form : The protein (1mg/ml) was lyophilized from a 0.2µm filtered concentrated solution in 1×PBS, pH 7.4.
Bio-activity : The ED50 as determined by a cell proliferation assay using murine CTLL-2 cells is less than 0.5ng/ml, corresponding to a specific activity of > 2.0 × 10^6 IU/mg.
Molecular Mass : 15217 Dalton
Protein length : 134 amino acids
AA Sequence : APTSSSTKNT KKQLEPLLLD LQLLLKEVKN YENADLSRML TFKFYMPKQA TELKHLQCLV EELKALEGVL NLGQSKNSDS ANIKESMNNI NVTVLELKGS ETSFKCEYDD ETVTAVEFLN KWITFCQSIY STLT.
Purity : Greater than 96.0% as determined by:
(a) Analysis by RP-HPLC.
(b) Analysis by SDS-PAGE.
Storage : Lyophilized IL2 although stable at room temperature for 3 weeks, should be stored desiccated below -18 centigrade. Upon reconstitution IL-2 should be stored at 4 centigrade between 2-7 days and for future use below -18 centigrade.
For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).
Please prevent freeze-thaw cycles.
Reconstitution : It is recommended to reconstitute the lyophilized IL 2 in sterile distilled H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.
Gene Name : IL2 interleukin 2 [ Sus scrofa ]
Official Symbol : IL2
Synonyms : IL-2; TCGF; POIL2; T-cell growth factor
Gene ID : 396868
mRNA Refseq : NM_213861
Protein Refseq : NP_999026
UniProt ID : P26891

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (10)

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What is the impact of IL2 on T-cell memory formation? 04/25/2022

IL2 promotes the formation of memory T-cells.

What is the role of IL2 in the tumor microenvironment? 12/12/2021

IL2 has a pro-tumorigenic role in the tumor microenvironment.

How does IL2 interact with other cytokines in a mixed environment? 11/22/2021

IL2 synergizes with IL-12 in a mixed cytokine environment.

Does IL2 modulate the expression of checkpoint inhibitors? 06/03/2020

IL2 upregulates the expression of PD-1 checkpoint inhibitors.

What are the kinetics of IL2 internalization in T cells? 08/18/2019

IL2 is rapidly internalized by activated T-cells.

Does IL2 influence the polarization of macrophages? 07/24/2019

IL2 induces M1 macrophage polarization.

How does IL2 affect the blood-brain barrier permeability? 07/06/2018

IL2 increases blood-brain barrier permeability.

How does IL2's affinity for its receptor change under hypoxic conditions? 04/11/2018

IL2's affinity for its receptor decreases under hypoxic conditions.

What post-translational modifications affect IL2's bioactivity? 02/19/2017

IL2's bioactivity is enhanced by glycosylation.

What is the role of IL2 in the differentiation of Th17 cells? 04/20/2016

IL2 promotes the differentiation of Th17 cells.

Customer Reviews (3)

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Reviews
04/13/2022

    Potent in T-cell activation.

    07/27/2018

      Suitable for cytokine assays.

      01/07/2018

        High stability.

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