Active Recombinant Porcine IL2 Protein
Cat.No. : | IL2-83P |
Product Overview : | Recombinant Porcine IL2 was expressed in E. coli. |
- Specification
- Gene Information
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Description : | IL2 is a secreted cytokine that is important for the proliferation of T and B lymphocytes. The receptor of this cytokine is a heterotrimeric protein complex whose gamma chain is also shared by interleukin 4 (IL4) and interleukin 7 (IL7). The expression of this gene in mature thymocytes is monoallelic, which represents an unusual regulatory mode for controlling the precise expression of a single gene. The targeted disruption of a similar gene in mice leads to ulcerative colitis-like disease, which suggests an essential role of this gene in the immune response to antigenic stimuli. |
Source : | E. coli |
Species : | Porcine |
Form : | The protein (1mg/ml) was lyophilized from a 0.2µm filtered concentrated solution in 1×PBS, pH 7.4. |
Bio-activity : | The ED50 as determined by a cell proliferation assay using murine CTLL-2 cells is less than 0.5ng/ml, corresponding to a specific activity of > 2.0 × 10^6 IU/mg. |
Molecular Mass : | 15217 Dalton |
Protein length : | 134 amino acids |
AA Sequence : | APTSSSTKNT KKQLEPLLLD LQLLLKEVKN YENADLSRML TFKFYMPKQA TELKHLQCLV EELKALEGVL NLGQSKNSDS ANIKESMNNI NVTVLELKGS ETSFKCEYDD ETVTAVEFLN KWITFCQSIY STLT. |
Purity : | Greater than 96.0% as determined by: (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE. |
Storage : | Lyophilized IL2 although stable at room temperature for 3 weeks, should be stored desiccated below -18 centigrade. Upon reconstitution IL-2 should be stored at 4 centigrade between 2-7 days and for future use below -18 centigrade. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles. |
Reconstitution : | It is recommended to reconstitute the lyophilized IL 2 in sterile distilled H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions. |
Gene Name : | IL2 interleukin 2 [ Sus scrofa ] |
Official Symbol : | IL2 |
Synonyms : | IL-2; TCGF; POIL2; T-cell growth factor |
Gene ID : | 396868 |
mRNA Refseq : | NM_213861 |
Protein Refseq : | NP_999026 |
UniProt ID : | P26891 |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (10)
Ask a questionIL2 promotes the formation of memory T-cells.
IL2 has a pro-tumorigenic role in the tumor microenvironment.
IL2 synergizes with IL-12 in a mixed cytokine environment.
IL2 upregulates the expression of PD-1 checkpoint inhibitors.
IL2 is rapidly internalized by activated T-cells.
IL2 induces M1 macrophage polarization.
IL2 increases blood-brain barrier permeability.
IL2's affinity for its receptor decreases under hypoxic conditions.
IL2's bioactivity is enhanced by glycosylation.
IL2 promotes the differentiation of Th17 cells.
Customer Reviews (3)
Write a reviewPotent in T-cell activation.
Suitable for cytokine assays.
High stability.
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