Active Recombinant Rhesus Macaque CD4 Homodimer Protein, His tagged

• Cat.No.: CD4-19R
• Product Overview: CD4 dimer protein contains a CD4 extracellular domain (UniProt# P16003) fused with a proprietary cis-dimer motif followed by a His tag at the C-terminus was expressed in HEK293T.

Specification

• Species: Rhesus Macaque
• Source: HEK293T
• Tag: His
• Protein Length: 26-396 aa
• Description: CD4 is Type 1 integral membrane glycoprotein protein on a T cell surface, also known as known as T-cell surface antigen T4/Leu-3. CD4 contains an extracellular domain, a transmembrane domain and a cytoplasmic domain. The extracellular domain has 4 immunoglobulin-like (Ig-like) domains: one Ig-like V-type domain and three Ig-like C2-type domains. The CD4 extracellular domain is responsible for MHC class-II antigen/T-cell receptor interaction and T cell activation. CD4 is also known as interleukin 16 receptor (IL16R). The IL16 cytokine binds CD4 to activate a downstream signaling cascade. CD4 is also the primary receptor for the human immunodeficiency virus (HIV) envelope glycoprotein gp120 to mediate HIV infection and entry into host T cells, as the underlying cause of acquired immune deficiency syndrome (AIDS). Rhesus macaque CD4 is a species-specific tool essential for preclinical studies, basic research, and translational research in cancer immunotherapy.
• Molecular Mass: 98 kDa
• Purity: Greater than 90% dimer form as determined by SDS-PAGE under non-reducing condition
• Application: Verified Applications: ELISA for CD4-specific antibody binding assays. Suggested Applications: SPR & BLI for CD4-specific antibody binding assays. Animal immunization, RUO.
• Storage: Store at -80 centigrade.
• Storage Buffer: 0.22μm filtered PBS, pH 7.4
• Shipping: Frozen Dry Ice

Gene Information

• Gene Name: CD4 CD4 molecule [ Macaca mulatta (Rhesus monkey) ]
• Official Symbol: CD4
• Synonyms: CD4; CD4 molecule; T-cell surface glycoprotein CD4; CD4 antigen; T-cell surface antigen T4/Leu-3
• Gene ID: 713807
• mRNA Refseq: NM_001042662
• Protein Refseq: NP_001036127
• UniProt ID: P16003