Active Recombinant S. aureus IMPDH Protein

• Cat.No.: IMPDH-10S
• Product Overview: IMPDH is a cloned protein of 53 kDa cloned by PCR amplification of guaB gene of Staphylococcus aureus and expressed in E. coli.

Specification

• Species: S.aureus
• Source: E.coli
• Description: Today, antibiotic resistance is one of the world's most important public health problems. There is an urgent need for new antibiotic compounds acting on new targets. One attractive strategy for developing new antibiotics consists in inhibiting bacterial IMPDH, an enzyme involved in the de novo synthesis of purine nucleotides, and therefore, necessary for bacterial cell growth and division. Mammalian and bacterial IMPDHs are known to have significantly different kinetic properties and inhibitor sensitivities.
• Bio-activity: Specific Activity: ≥ 0.3 unit/mg protein.
• Molecular Mass: 53 kDa
• Purity: Controlled by 12% AA SDS-PAGE.
• Unit Definition: One unit of IMPDH converts 1.0 μmole of IMP and NAD to XMP and NADH per minute at pH 8 at 37 centigrade.

Gene Information

• Official Symbol: IMPDH
• Synonyms: EC 1.1.1.205; inosine 5'-monophosphate dehydrogenase; IMP dehydrogenase; IMPDH