Active Recombinant SARS-CoV-2 papain-like protease Protein, His-tagged
Cat.No. : | PLpro-167S |
Product Overview : | Active recombinant SARS-CoV-2 N-terminal His-tagged papain-like protease was expressed in E. coli. |
- Specification
- Gene Information
- Related Products
Description : | Replication of severe acute respiratory syndrome (SARS) coronavirus (SARS-CoV) requires proteolytic processing of the replicase polyprotein by two viral cysteine proteases,a chymotrypsin-like protease (3CLpro) and a papain-like protease (PLpro).These proteases are important targets for development of antiviral drugs that would inhibit viral replication and reduce mortality associated with outbreaks of SARS-CoV.PLpro is a cysteine protease located within the non-structural protein 3 (NS3) section of the viral polypeptide.PLPro activity is required to process the viral polyprotein into functional,mature subunits;specifically,PLPro cleaves a site at the amino-terminus of the viral replicase region.In addition to its role in viral protein maturation,PLPro possesses a deubiquitinating and deISGylating activity.In vivo,this protease antagonizes innate immunity by inhibiting IRF3-induced production of type I interferons. |
Source : | E. coli |
Species : | SARS-CoV-2 |
Tag : | His |
Form : | Lyophilized |
Bio-activity : | >80 pmols/min/μg |
Molecular Mass : | 36.8 kDa |
Protein length : | 1564-1880 |
Purity : | ≥90% estimated by SDS-PAGE |
Stability : | ≥ 6 months |
Storage : | At -80 centigrade. |
Storage Buffer : | Lyophilized from sterile 20 mM Tris, pH 7.4, with 500 mM sodium chloride |
Synonyms : | 2019-nCoV PLpro; COVID-19-PLpro; SARS-CoV-2 PLpro; Severe Acute Respiratory Syndrome Coronavirus 2 Papain-like Protease |
Synonyms : | 2019-nCoV PLpro; COVID-19-PLpro; SARS-CoV-2 PLpro; Severe Acute Respiratory Syndrome Coronavirus 2 Papain-like Protease |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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