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ALDH Activity Fluorometric Assay Kit

Cat.No. : Kit-0075
Product Overview : ALDH Activity Assay Kit (Fluorometric) is a quantitative fluorometric determination of ALDH activity.
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Storage : Store kit at -20°C, protect from light. Let ALDH Assay Buffer warm to room temperature before use. Briefly centrifuge all small vials prior to opening.

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (19)

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How are ALDH proteins regulated in the body? 01/08/2023

ALDH proteins are regulated through various mechanisms, including gene expression, post-translational modifications, and cellular localization. The expression of ALDH genes can be regulated by transcription factors, epigenetic modifications, and signaling pathways. Additionally, post-translational modifications such as phosphorylation, acetylation, and ubiquitination can modulate the activity of ALDH proteins. The cellular localization of ALDH enzymes can also be regulated, ensuring their proper subcellular localization for optimal function.

Can ALDH proteins be targeted for therapeutic interventions? 05/17/2022

Yes, ALDH proteins can be targeted for therapeutic interventions. As mentioned earlier, drugs like disulfiram are known ALDH inhibitors and are used in the treatment of alcoholism. In addition to alcohol use disorder, ALDH inhibitors have been explored for potential use in cancer treatment. By targeting ALDH enzymes, these inhibitors aim to eliminate or suppress cancer stem cells, which are believed to drive tumor growth, metastasis, and resistance to chemotherapy.

Can ALDH proteins be targeted for therapeutic purposes? 03/16/2022

Yes, ALDH proteins have been explored as potential targets for therapeutic interventions. In cancer treatment, targeting ALDH activity in cancer stem cells is being investigated as a strategy to overcome drug resistance and improve treatment outcomes. In addition, ALDH inhibitors have been developed and tested as potential therapies for various diseases. For example, disulfiram, an FDA-approved drug for alcoholism, acts as an ALDH inhibitor and has shown promise in repurposing for the treatment of cancer and infectious diseases.

What are the different isoforms of ALDH proteins? 08/26/2021

There are multiple isoforms of ALDH proteins, each encoded by a distinct gene. Some well-known ALDH isoforms include ALDH1A1, ALDH1A2, ALDH1A3, ALDH2, and ALDH3A1. Each isoform has different enzymatic properties and substrate specificities, leading to diverse physiological functions.

Are ALDH proteins involved in drug resistance? 06/06/2021

Yes, ALDH proteins have been implicated in drug resistance mechanisms in various cancers. ALDH activity has been associated with the survival and drug resistance of cancer stem cells, which are thought to play a role in tumor initiation, recurrence, and resistance to therapy.

Are there any ALDH-related diseases? 11/06/2020

Yes, alterations in ALDH proteins or their activity have been associated with various diseases. For example, ALDH2 deficiency, caused by certain genetic variants, is associated with alcohol intolerance and an increased risk of alcohol-related disorders. ALDH enzymes have also been implicated in certain neurodegenerative diseases, such as Parkinson's disease and Alzheimer's disease, as they are involved in the metabolism of toxic aldehydes.

Can ALDH proteins be used as diagnostic or prognostic markers? 02/09/2020

Yes, ALDH proteins have been investigated as potential diagnostic and prognostic markers in various diseases. Elevated expression of certain ALDH isoforms has been observed in cancer stem cells and is associated with tumor aggressiveness, drug resistance, and poor prognosis. ALDH activity or expression levels can be measured using various laboratory techniques and may provide valuable information for disease management.

Are there any natural compounds that can modulate ALDH activity? 01/04/2020

Yes, several natural compounds have been found to modulate ALDH activity. For example, certain dietary phytochemicals, such as resveratrol found in grapes and curcumin found in turmeric, have been reported to increase ALDH activity. These compounds may have potential health benefits by promoting detoxification and reducing oxidative stress.

How is ALDH activity measured experimentally? 01/03/2020

ALDH activity can be measured using various experimental techniques. One commonly used method is based on the conversion of aldehydes into their corresponding carboxylic acids, which can be detected using chemical assays or spectroscopic methods.

Are there any conditions where increased ALDH activity is beneficial? 06/12/2019

Yes, increased ALDH activity can be beneficial in certain conditions. For example, in the context of chemotherapy, cancer stem cells with high ALDH activity are often associated with resistance to treatment. Inhibiting or targeting ALDH activity in these cells can improve the efficacy of chemotherapy and reduce the risk of recurrence.

Are there any potential drawbacks or challenges in targeting ALDH proteins for therapy? 06/27/2018

While ALDH proteins offer potential therapeutic opportunities, there are challenges to consider. ALDHs are a diverse family of proteins, and the specificity of targeting a particular isoform or achieving selective inhibition can be difficult.

How does the expression and activity of ALDH proteins vary among different tissues and cell types? 08/31/2017

The expression and activity of ALDH proteins can vary among different tissues and cell types. ALDH enzymes are found in various organs, including the liver, brain, heart, and gastrointestinal tract, with each tissue expressing different isoforms of ALDH enzymes. The levels of ALDH expression can vary depending on cell differentiation status, developmental stage, and functional requirements of the tissue.

Are there any genetic disorders associated with ALDH proteins? 04/23/2017

Yes, genetic disorders can occur due to mutations or alterations in ALDH genes. For example, genetic variants in ALDH2 can result in ALDH2 deficiency, which is characterized by impaired alcohol metabolism and a higher risk of alcohol-induced flushing, increased heart rate, and other symptoms. This deficiency is most commonly observed in East Asian populations.

Are there any ALDH inhibitors available? 01/23/2017

Yes, several ALDH inhibitors have been developed and studied for their potential therapeutic applications. Some ALDH inhibitors have shown promise in cancer treatment by targeting cancer stem cells or enhancing the effectiveness of chemotherapy drugs. Disulfiram and its derivatives are examples of ALDH inhibitors that have been tested in preclinical and clinical trials.

Are there any genetic variations in ALDH genes? 09/27/2016

Yes, genetic variations in ALDH genes have been identified, and some variants have been associated with altered enzyme activity or increased susceptibility to certain diseases. For example, polymorphisms in ALDH2 gene are prevalent in East Asian populations and result in decreased enzyme activity, leading to alcohol intolerance and increased risk of alcohol-related diseases.

Can ALDH proteins be used as biomarkers? 09/11/2016

Yes, ALDH proteins have been explored as potential biomarkers in certain diseases and conditions. For example, ALDH activity can be used as a marker of stem cell populations, as higher ALDH activity is often associated with stem cell-like characteristics. ALDH expression levels have also been investigated as potential prognostic indicators in some cancers, where high ALDH expression is associated with poor outcomes and increased resistance to therapy.

Can ALDH proteins be used for drug discovery? 07/14/2016

Yes, ALDH proteins have been studied as potential drug targets and biomarkers in various diseases, including cancer, cardiovascular diseases, and neurodegenerative disorders. Modulating the activity of ALDH enzymes can affect important cellular processes and pathways, making them attractive targets for therapeutic interventions.

What other physiological functions are associated with ALDH proteins? 05/07/2016

Apart from their role in detoxification, ALDH proteins are involved in various physiological functions. They participate in the metabolism of neurotransmitters, retinoids, and lipids, suggesting their involvement in neurotransmission, vision, and lipid homeostasis. ALDH enzymes are also implicated in the synthesis and oxidation of biologically active compounds, including hormones, growth factors, and secondary metabolites. Additionally, ALDH isoforms have been linked to stem cell maintenance, tissue development, and immune responses.

Are there any drugs that target ALDH proteins? 04/09/2016

Yes, several drugs have been developed to target ALDH enzymes. Disulfiram, as mentioned earlier, acts as an ALDH inhibitor and is used in treating alcoholism. It works by inhibiting ALDH and causing an accumulation of acetaldehyde, leading to unpleasant symptoms upon alcohol consumption, discouraging further drinking.

Customer Reviews (4)

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Reviews
11/02/2022

    In addition to its outstanding quality, the ALDH Protein exhibits exceptional stability during storage and usage.

    11/12/2021

      Equally noteworthy is the remarkable technical support provided by the manufacturer.

      02/10/2021

        With its remarkable purity and reliability, coupled with the manufacturer's excellent technical support, this protein is a crucial asset in addressing my scientific inquiries and advancing my research goals.

        11/26/2019

          Their team of experts has been instrumental in addressing any issues or concerns I have encountered during my experiments.

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