Recombinant Human Translin, T7-tagged

• Cat.No.: TSN-3001H
• Product Overview: Recombinant Human TSN protein was expressed in E.coli with T7-tag at the N-terminus. The molecular weight is 26183 Da(228 aa).

Specification

• Species: Human
• Source: E.coli
• Tag: T7
• Description: Translin is a protein that in humans is encoded by the TSN gene. This gene encodes a DNA-binding protein which specifically recognizes conserved target sequences at the breakpoint junction of chromosomal translocations. Translin polypeptides form a multimeric structure that is responsible for its DNA-binding activity. Recombination-associated motifs and translin-binding sites are present at recombination hotspots and may serve as indicators of breakpoints in genes which are fused by translocations. These binding activities may play a crucial role in chromosomal translocation in lymphoid neoplasms.
• Sequences of amino acids: 1-228 aa
• Formulation: 10 mM Tris. pH 8.0. 0.1% Triton X-100. 0.002% NaN3.
• Purity: 95%

Gene Information

• Gene Name: TSN translin [ Homo sapiens ]
• Synonyms: RCHF1; TBRBP; TRSLN; BCLF-1; REHF-1; translin; OTTHUMP00000203715; OTTHUMP00000203716; recombination hotspot-binding protein; recombination hotspot associated factor
• Gene ID: 7247
• mRNA Refseq: NM_004622
• Protein Refseq: NP_004613
• MIM: 600575
• UniProt ID: Q15631
• Chromosome Location: 2q21.1
• Function: DNA binding; mRNA binding; protein binding; sequence-specific DNA binding