Recombinant Human IMPA2 protein, His-tagged

• Cat.No.: IMPA2-3454H
• Product Overview: Recombinant Human IMPA2(1-288aa) fused with His tag at N-terminal was expressed in E. coli.

Specification

• Description: IMPA2 belongs to the inositol monophosphatase family. This protein can use myo-inositol monophosphates, scylloinositol 1,4-diphosphate, glucose-1-phosphate, beta-glycerophosphate, and 2"-AMP as substrates. IMPA2 has been implicated as the pharmacological target for lithium Li(+) action in brain. IMPA2 is thought to play a role in schizophrenia and bipolar disorder.
• Source: E. coli
• Species: Human
• Tag: His
• Form: Liquid. In 20mM Tris-HCl buffer(pH 8.0) containing 10% glycerol, 2mM DTT.
• Molecular Mass: 33.5 kDa (308aa), confirmed by MALDI-TOF
• AA Sequence: MGSSHHHHHH SSGLVPRGSH MKPSGEDQAA LAAGPWEECF QAAVQLALRA GQIIRKALTE EKRVSTKTSA ADLVTETDHL VEDLIISELR ERFPSHRFIA EEAAASGAKC VLTHSPTWII DPIDGTCNFV HRFPTVAVSI GFAVRQELEF GVIYHCTEER LYTGRRGRGA FCNGQRLRVS GETDLSKALV LTEIGPKRDP ATLKLFLSNM ERLLHAKAHG VRVIGSSTLA LCHLASGAAD AYYQFGLHCW DLAAATVIIR EAGGIVIDTS GGPLDLMACR VVAASTREMA MLIAQALQTI NYGRDDEK
• Purity: >95% by SDS - PAGE
• Storage: Can be stored at +4 centigrade short term (1-2 weeks). For long term storage, aliquot and store at -20 centigrade or -70 centigrade. Avoid repeated freezing and thawing cycles.
• Concentration: 0.25 mg/ml (determined by Bradford assay)

Gene Information

• Gene Name: IMPA2 inositol(myo)-1(or 4)-monophosphatase 2 [ Homo sapiens ]
• Official Symbol: IMPA2
• Synonyms: IMPA2; inositol(myo)-1(or 4)-monophosphatase 2; inositol monophosphatase 2; IMP 2; IMPase 2; inosine monophosphatase 2; myo-inositol monophosphatase A2; inositol monophosphatase 2 variant 1; inositol monophosphatase 2 variant 2
• Gene ID: 3613
• mRNA Refseq: NM_014214
• Protein Refseq: NP_055029
• MIM: 605922
• UniProt ID: O14732
• Chromosome Location: 18p11.2
• Pathway: D-myo-inositol (1,4,5)-trisphosphate degradation, organism-specific biosystem; D-myo-inositol (1,4,5)-trisphosphate degradation, conserved biosystem; Inositol phosphate metabolism, organism-specific biosystem; Inositol phosphate metabolism, conserved biosystem; Inositol phosphate metabolism, Ins(1,3,4,5)P4 =>Ins(1,3,4)P3 => myo-inositol, organism-specific biosystem
• Function: hydrolase activity; inositol monophosphate 1-phosphatase activity; inositol monophosphate 3-phosphatase activity; inositol monophosphate 4-phosphatase activity; metal ion binding; protein homodimerization activity