"HPD" Related Products

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Recombinant Human HPD, His-tagged

Cat. No. : HPD-2842H
Product Overview : Recombinant human HPD protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques. MW = 47 kDa (413aa) confirmed by MALDI-TOF.
Description : 4-hydroxyphenylpyruvate dioxygenase isoform 1, also known as HPD, is an Fe-containing enzyme, that catalyzes the second reaction in the catabolism of tyrosine the conversion of 4-hydroxyphenylpyruvate to homogentisate. Existing as a homodimer, HPD uses zinc as a cofactor to catalyze the third step in the conversion of L-phenylalanine to fumarate and acetoacetic acid. Defects in the gene encoding HPD are the cause of tyrosinemia type 3 and hawkinsinuria, both of which are inborn errors of metabolism that are associated with a variety of symptoms, including mental retardation and seizures and hair and urine abnormalities.
Source : E.coli.
Sequences Of Amino Acids : MGSSHHHHHH SSGLVPRGSH MTTYSDKGAK PERGRFLHFH SVTFWVGNAK QAASFYCSKM GFEPLAYRGL ETGSREVVSH VIKQGKIVFV LSSALNPWNK EMGDHLVKHG DGVKDIAFEV EDCDYIVQKA RERGAKIMRE PWVEQDKFGK VKFAVLQTYG DTTHTLVEKM NYIGQFLPGY EAPAFMDPLL PKLPKCSLEM IDHIVGNQPD QEMVSASEWY LKNLQFHRFW SVDDTQVHTE YSSLRSIVVA NYEESIKMPI NEPAPGKKKS QIQEYVDYNG GAGVQHIALK TEDIITAIRH LRERGLEFLS VPSTYYKQLR EKLKTAKIKV KENIDALEEL KILVDYDEKG YLLQIFTKPV QDRPTLFLEV IQRHNHQGFG AGNFNSLFKA FEEEQNLRGN LTNMETNGVV PGM
Purity : > 90% by SDS – PAGE.
Form : Liquid. In 20mM Tris-HCl buffer (pH 8.0) containing 1mM DTT, 20% glycerol, 50mM NaCl.
Concentration : 1 mg/ml (determined by Bradford assay).
Storage : Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles.
Gene Name : HPD 4-hydroxyphenylpyruvate dioxygenase [ Homo sapiens ]
Synonyms : HPD; 4-hydroxyphenylpyruvate dioxygenase; PPD; 4HPPD; GLOD3; 4-HPPD; HPPDASE; glyoxalase domain containing 3; 4-hydroxyphenylpyruvic acid oxidase; EC 1.13.11.27
Gene ID : 3242
mRNA Refseq : NM_001171993
Protein Refseq : NP_001165464
MIM : 609695
UniProt ID : P32754
Chromosome Location : 12q24-qter
Pathway : Metabolic pathways; Phenylalanine metabolism; Tyrosine metabolism; Ubiquinone and other terpenoid-quinone biosynthesis
Function : 4-hydroxyphenylpyruvate dioxygenase activity; metal ion binding; oxidoreductase activity

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