Recombinant Human PTP4A1(2-173), His-tagged PTP4A1-504H

Cat. No.:	PTP4A1-504H
Product Overview:	Recombinant human PTP4A1 protein(2-173) with N-terminal His tag was expressed in anE.coliexpression system, MW= 19.8 kDa.
Description:	Protein tyrosine phosphatase type IVA 1 is an enzyme that in humans is encoded by the PTP4A1 gene. The protein encoded by this gene belongs to a small class of prenylated protein tyrosine phosphatases (PTPs), which contains a PTP domain and a characteristic C-terminal prenylation motif. PTPs are cell signaling molecules that play regulatory roles in a variety of cellular processes. This tyrosine phosphatase is a nuclear protein, but may primarily associate with plasma membrane. The surface membrane association of this protein depends on its C-terminal prenylation.
Source:	E.coli.
Purity:	> 90%.
Formulation:	25 mM Tris-HCl, pH 8.0, 100 mM NaCl, 0.05% Tween-20, 20% glycerol, and 3 mM DTT.
Specific Activity:	0.168 pmol/min/μg, Assay conditions: enzyme was incubated in50mM Tris pH7.4, 150mM NaCl 5mM DTT, and 12.5mM PNPP as a substrate for 2h at 37°C. Absorbance was read by Tecan spectraphotometer at 405 nm wavelength.
Application:	Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.
Storage:	>6 months at –80°C.

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Gene Name:	PTP4A1 protein tyrosine phosphatase type IVA, member 1 [ Homo sapiens ]
Synonyms:	PTP4A1; protein tyrosine phosphatase type IVA, member 1; HH72; PRL1; PRL-1; PTPCAAX1; PTP(CAAX1); DKFZp779M0721; PTP(CAAXI); protein-tyrosine phosphatase 4a1; Protein tyrosine phosphatase IVA1; protein tyrosine phosphatase type IVA protein 1; protein-tyrosine phosphatase of regenerating liver 1; EC 3.1.3.48
Gene ID:	7803
mRNA Refseq:	NM_003463
Protein Refseq:	NP_003454
MIM:	601585
UniProt ID:	Q93096
Chromosome Location:	6q12
Function:	hydrolase activity; protein tyrosine phosphatase activity