Recombinant Human Smad Nuclear Interacting Protein 1, His-tagged
Cat.No. : | SNIP1-5127H |
Product Overview : | Recombinant human SNIP1 protein,fused to His-tag at N-terminus, was expressed in E. coli and purified byusing conventional chromatography techniques. |
- Specification
- Gene Information
- Related Products
Cat. No. : | SNIP1-5127H |
Description : | SNIP1 is smad nuclear interactingprotein contains a forkhead-associated (FHA) domain and acts as a nuclearinhibitor of CBP/p300. This protein is an inhibitor of the TGF-beta signaltransduction pathway and is important in suppressing transcriptionalactivation dependent on the co-activators CBP and p300. Inhibition ofNF-kappa B activity is a function of the N-terminal domain of SNIP1 andinvolves competition of SNIP1 and the NF-kappa B subunit, RelA/p65, for bindingto p300, similar to the mechanism of inhibition of Smad signaling by SNIP1. |
Concentration : | 1 mg/ml |
Source : | Human |
Host : | E.coli |
Form : | Suppliedas a liquid in 20mM Tris-HCl buffer, pH 8.0, containing 2mM DTT, 20% glyceroland 100mM NaCl. |
Purity : | > 90% by SDS -PAGE |
Sequence : | 258-396 amino acids:MGSSHHHHHH SSGLVPRGSH MRWRLYPFKN DEVLPVMYIH RQSAYLLGRH RRIADIPIDH PSCSKQHAVFQYRLVEYTRA DGTVGRRVKP YIIDLGSGNG TFLNNKRIEP QRYYELKEKD VLKFGFSSRE YVLLHESSDTSEIDRKDDED EEEEEEVSDS |
Molecular Mass : | 18.8 kDa(160aa), confirmed by MALDI-TOF. |
Applications : | SDS-PAGE |
Storage : | Storeat 4 deg C for short term storage (1/2 weeks). Aliquot and store at -20 deg Cor - 70 deg C for long term storage. Avoid repeated freeze/thaw cycles. |
OfficialSymbol : | SNIP1 |
Pathways : | Regulation ofnuclear SMAD2/3 signaling; TGF-beta Receptor Signaling Pathway |
Gene Name : | SNIP1 Smad nuclear interactingprotein 1 [ Homo sapiens ] |
Synonyms : | SNIP1;Smad nuclear interacting protein 1; FLJ12553;dJ423B22.2; RP3-423B22.3; smad nuclear-interacting protein 1; FHAdomain-containing protein SNIP1; Smad nuclear interacting protein (SNIP1); Smad nuclear-interacting protein 1; OTTHUMP00000004404 |
Gene ID : | 79753 |
mRNA Refseq : | NM_024700 |
Protein Refseq : | NP_078976 |
MIM : | 608241 |
UniProt ID : | Q8TAD8 |
Chromosome Location : | 1p34.3 |
Function : | proteinbinding |
Products Types
◆ Recombinant Protein | ||
SNIP1-4184R | Recombinant Rhesus Macaque SNIP1 Protein, His (Fc)-Avi-tagged | +Inquiry |
SNIP1-5302R | Recombinant Rat SNIP1 Protein, His (Fc)-Avi-tagged | +Inquiry |
SNIP1-3108Z | Recombinant Zebrafish SNIP1 | +Inquiry |
SNIP1-2843H | Recombinant Human SNIP1, His-tagged | +Inquiry |
SNIP1-692H | Recombinant Human Smad nuclear interacting protein 1, His-tagged | +Inquiry |
◆ Lysates | ||
SNIP1-1628HCL | Recombinant Human SNIP1 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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