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- Rhesus Macaque(1)
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Recombinant Human Smad Nuclear Interacting Protein 1, His-tagged
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| Cat. No. : | SNIP1-5127H |
| Product Overview : | Recombinant human SNIP1 protein,fused to His-tag at N-terminus, was expressed in E. coli and purified byusing conventional chromatography techniques. |
| Description : | SNIP1 is smad nuclear interactingprotein contains a forkhead-associated (FHA) domain and acts as a nuclearinhibitor of CBP/p300. This protein is an inhibitor of the TGF-beta signaltransduction pathway and is important in suppressing transcriptionalactivation dependent on the co-activators CBP and p300. Inhibition ofNF-kappa B activity is a function of the N-terminal domain of SNIP1 andinvolves competition of SNIP1 and the NF-kappa B subunit, RelA/p65, for bindingto p300, similar to the mechanism of inhibition of Smad signaling by SNIP1. |
| Concentration : | 1 mg/ml |
| Source : | Human |
| Host : | E.coli |
| Form : | Suppliedas a liquid in 20mM Tris-HCl buffer, pH 8.0, containing 2mM DTT, 20% glyceroland 100mM NaCl. |
| Purity : | > 90% by SDS -PAGE |
| Sequence : | 258-396 amino acids:MGSSHHHHHH SSGLVPRGSH MRWRLYPFKN DEVLPVMYIH RQSAYLLGRH RRIADIPIDH PSCSKQHAVFQYRLVEYTRA DGTVGRRVKP YIIDLGSGNG TFLNNKRIEP QRYYELKEKD VLKFGFSSRE YVLLHESSDTSEIDRKDDED EEEEEEVSDS |
| Molecular Mass : | 18.8 kDa(160aa), confirmed by MALDI-TOF. |
| Applications : | SDS-PAGE |
| Storage : | Storeat 4 deg C for short term storage (1/2 weeks). Aliquot and store at -20 deg Cor - 70 deg C for long term storage. Avoid repeated freeze/thaw cycles. |
| OfficialSymbol : | SNIP1 |
| Pathways : | Regulation ofnuclear SMAD2/3 signaling; TGF-beta Receptor Signaling Pathway |
| Gene Name : | SNIP1 Smad nuclear interactingprotein 1 [ Homo sapiens ] |
| Synonyms : | SNIP1;Smad nuclear interacting protein 1; FLJ12553;dJ423B22.2; RP3-423B22.3; smad nuclear-interacting protein 1; FHAdomain-containing protein SNIP1; Smad nuclear interacting protein (SNIP1); Smad nuclear-interacting protein 1; OTTHUMP00000004404 |
| Gene ID : | 79753 |
| mRNA Refseq : | NM_024700 |
| Protein Refseq : | NP_078976 |
| MIM : | 608241 |
| UniProt ID : | Q8TAD8 |
| Chromosome Location : | 1p34.3 |
| Function : | proteinbinding |
◆ Recombinant Protein
| SNIP1-5643R | Recombinant Rat SNIP1 Protein | +Inquiry |
| SNIP1-692H | Recombinant Human Smad nuclear interacting protein 1, His-tagged | +Inquiry |
| SNIP1-2843H | Recombinant Human SNIP1, His-tagged | +Inquiry |
| SNIP1-3537H | Recombinant Human SNIP1, His-tagged | +Inquiry |
| SNIP1-4368R | Recombinant Rhesus monkey SNIP1 Protein, His-tagged | +Inquiry |
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◆ Lysates
| SNIP1-1628HCL | Recombinant Human SNIP1 293 Cell Lysate | +Inquiry |
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