Cat. No. :	SNIP1-5127H
Product Overview :	Recombinant human SNIP1 protein,fused to His-tag at N-terminus, was expressed in E. coli and purified byusing conventional chromatography techniques.
Description :	SNIP1 is smad nuclear interactingprotein contains a forkhead-associated (FHA) domain and acts as a nuclearinhibitor of CBP/p300. This protein is an inhibitor of the TGF-beta signaltransduction pathway and is important in suppressing transcriptionalactivation dependent on the co-activators CBP and p300. Inhibition ofNF-kappa B activity is a function of the N-terminal domain of SNIP1 andinvolves competition of SNIP1 and the NF-kappa B subunit, RelA/p65, for bindingto p300, similar to the mechanism of inhibition of Smad signaling by SNIP1.
Concentration :	1 mg/ml
Source :	Human
Host :	E.coli
Form :	Suppliedas a liquid in 20mM Tris-HCl buffer, pH 8.0, containing 2mM DTT, 20% glyceroland 100mM NaCl.
Purity :	> 90% by SDS -PAGE
Sequence :	258-396 amino acids:MGSSHHHHHH SSGLVPRGSH MRWRLYPFKN DEVLPVMYIH RQSAYLLGRH RRIADIPIDH PSCSKQHAVFQYRLVEYTRA DGTVGRRVKP YIIDLGSGNG TFLNNKRIEP QRYYELKEKD VLKFGFSSRE YVLLHESSDTSEIDRKDDED EEEEEEVSDS
Molecular Mass :	18.8 kDa(160aa), confirmed by MALDI-TOF.
Applications :	SDS-PAGE
Storage :	Storeat 4 deg C for short term storage (1/2 weeks). Aliquot and store at -20 deg Cor - 70 deg C for long term storage. Avoid repeated freeze/thaw cycles.
OfficialSymbol :	SNIP1
Pathways :	Regulation ofnuclear SMAD2/3 signaling; TGF-beta Receptor Signaling Pathway

Gene Name :	SNIP1 Smad nuclear interactingprotein 1 [ Homo sapiens ]
Synonyms :	SNIP1;Smad nuclear interacting protein 1; FLJ12553;dJ423B22.2; RP3-423B22.3; smad nuclear-interacting protein 1; FHAdomain-containing protein SNIP1; Smad nuclear interacting protein (SNIP1); Smad nuclear-interacting protein 1; OTTHUMP00000004404
Gene ID :	79753
mRNA Refseq :	NM_024700
Protein Refseq :	NP_078976
MIM :	608241
UniProt ID :	Q8TAD8
Chromosome Location :	1p34.3
Function :	proteinbinding

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