Recombinant Human Smad Nuclear Interacting Protein 1, His-tagged SNIP1-5127H

Recombinant Human Smad Nuclear Interacting Protein 1, His-tagged

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Recombinant Human Smad Nuclear Interacting Protein 1, His-tagged

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Cat. No. : SNIP1-5127H
Product Overview : Recombinant human SNIP1 protein,fused to His-tag at N-terminus, was expressed in E. coli and purified byusing conventional chromatography techniques.
Description : SNIP1 is smad nuclear interactingprotein contains a forkhead-associated (FHA) domain and acts as a nuclearinhibitor of CBP/p300. This protein is an inhibitor of the TGF-beta signaltransduction pathway and is important in suppressing transcriptionalactivation dependent on the co-activators CBP and p300. Inhibition ofNF-kappa B activity is a function of the N-terminal domain of SNIP1 andinvolves competition of SNIP1 and the NF-kappa B subunit, RelA/p65, for bindingto p300, similar to the mechanism of inhibition of Smad signaling by SNIP1.
Concentration : 1 mg/ml
Source : Human
Host : E.coli
Form : Suppliedas a liquid in 20mM Tris-HCl buffer, pH 8.0, containing 2mM DTT, 20% glyceroland 100mM NaCl.
Purity : > 90% by SDS -PAGE
Sequence : 258-396 amino acids:MGSSHHHHHH SSGLVPRGSH MRWRLYPFKN DEVLPVMYIH RQSAYLLGRH RRIADIPIDH PSCSKQHAVFQYRLVEYTRA DGTVGRRVKP YIIDLGSGNG TFLNNKRIEP QRYYELKEKD VLKFGFSSRE YVLLHESSDTSEIDRKDDED EEEEEEVSDS
Molecular Mass : 18.8 kDa(160aa), confirmed by MALDI-TOF.
Applications : SDS-PAGE
Storage : Storeat 4 deg C for short term storage (1/2 weeks). Aliquot and store at -20 deg Cor - 70 deg C for long term storage. Avoid repeated freeze/thaw cycles.
OfficialSymbol : SNIP1
Pathways : Regulation ofnuclear SMAD2/3 signaling; TGF-beta Receptor Signaling Pathway
Gene Name : SNIP1 Smad nuclear interactingprotein 1 [ Homo sapiens ]
Synonyms : SNIP1;Smad nuclear interacting protein 1; FLJ12553;dJ423B22.2; RP3-423B22.3; smad nuclear-interacting protein 1; FHAdomain-containing protein SNIP1; Smad nuclear interacting protein (SNIP1); Smad nuclear-interacting protein 1; OTTHUMP00000004404
Gene ID : 79753
mRNA Refseq : NM_024700
Protein Refseq : NP_078976
MIM : 608241
UniProt ID : Q8TAD8
Chromosome Location : 1p34.3
Function : proteinbinding

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