"SNIP1" Related Products

Expand
Expand

Recombinant Human Smad Nuclear Interacting Protein 1, His-tagged

Cat. No.: SNIP1-5127H
Product Overview: Recombinant human SNIP1 protein,fused to His-tag at N-terminus, was expressed in E. coli and purified byusing conventional chromatography techniques.
Description: SNIP1 is smad nuclear interactingprotein contains a forkhead-associated (FHA) domain and acts as a nuclearinhibitor of CBP/p300. This protein is an inhibitor of the TGF-beta signaltransduction pathway and is important in suppressing transcriptionalactivation dependent on the co-activators CBP and p300. Inhibition ofNF-kappa B activity is a function of the N-terminal domain of SNIP1 andinvolves competition of SNIP1 and the NF-kappa B subunit, RelA/p65, for bindingto p300, similar to the mechanism of inhibition of Smad signaling by SNIP1.
Concentration: 1 mg/ml
Source: Human
Host: E.coli
Form: Suppliedas a liquid in 20mM Tris-HCl buffer, pH 8.0, containing 2mM DTT, 20% glyceroland 100mM NaCl.
Purity: > 90% by SDS -PAGE
Sequence: 258-396 amino acids:MGSSHHHHHH SSGLVPRGSH MRWRLYPFKN DEVLPVMYIH RQSAYLLGRH RRIADIPIDH PSCSKQHAVFQYRLVEYTRA DGTVGRRVKP YIIDLGSGNG TFLNNKRIEP QRYYELKEKD VLKFGFSSRE YVLLHESSDTSEIDRKDDED EEEEEEVSDS
Molecular Mass: 18.8 kDa(160aa), confirmed by MALDI-TOF.
Applications: SDS-PAGE
Storage: Storeat 4 deg C for short term storage (1/2 weeks). Aliquot and store at -20 deg Cor - 70 deg C for long term storage. Avoid repeated freeze/thaw cycles.
OfficialSymbol: SNIP1
Pathways: Regulation ofnuclear SMAD2/3 signaling; TGF-beta Receptor Signaling Pathway
Gene Name: SNIP1 Smad nuclear interactingprotein 1 [ Homo sapiens ]
Synonyms: SNIP1;Smad nuclear interacting protein 1; FLJ12553;dJ423B22.2; RP3-423B22.3; smad nuclear-interacting protein 1; FHAdomain-containing protein SNIP1; Smad nuclear interacting protein (SNIP1); Smad nuclear-interacting protein 1; OTTHUMP00000004404
Gene ID: 79753
mRNA Refseq: NM_024700
Protein Refseq: NP_078976
MIM: 608241
UniProt ID: Q8TAD8
Chromosome Location: 1p34.3
Function: proteinbinding

Online Inquiry

Note: There will be extra charge for optional service!
Optional requirements on this protein    +Expand
C-fusion    N-fusion   Non-tagged
His    GST   Fc   Others
<1.0 eu/μg    <0.1 eu/μg   <0.01 eu/μg   Not required
Monomer Isolation    Dimer Isolation    Not required
>80% by SDS-PAGE    >90% by SDS-PAGE   >95% by SDS-PAGE   Others

Please input "biomart" as verification code. Please review Creative BioMart's privacy policy for more information


Price does not include shipping and packaging costs.Request quote for final price.

Price Inquiry

Welcome! For price inquiries, please feel free to contact us through the form below. We will get back to you as soon as possible.