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| Cat. No.: | SNIP1-5127H |
| Product Overview: | Recombinant human SNIP1 protein,fused to His-tag at N-terminus, was expressed in E. coli and purified byusing conventional chromatography techniques. |
| Description: | SNIP1 is smad nuclear interactingprotein contains a forkhead-associated (FHA) domain and acts as a nuclearinhibitor of CBP/p300. This protein is an inhibitor of the TGF-beta signaltransduction pathway and is important in suppressing transcriptionalactivation dependent on the co-activators CBP and p300. Inhibition ofNF-kappa B activity is a function of the N-terminal domain of SNIP1 andinvolves competition of SNIP1 and the NF-kappa B subunit, RelA/p65, for bindingto p300, similar to the mechanism of inhibition of Smad signaling by SNIP1. |
| Concentration: | 1 mg/ml |
| Source: | Human |
| Host: | E.coli |
| Form: | Suppliedas a liquid in 20mM Tris-HCl buffer, pH 8.0, containing 2mM DTT, 20% glyceroland 100mM NaCl. |
| Purity: | > 90% by SDS -PAGE |
| Sequence: | 258-396 amino acids:MGSSHHHHHH SSGLVPRGSH MRWRLYPFKN DEVLPVMYIH RQSAYLLGRH RRIADIPIDH PSCSKQHAVFQYRLVEYTRA DGTVGRRVKP YIIDLGSGNG TFLNNKRIEP QRYYELKEKD VLKFGFSSRE YVLLHESSDTSEIDRKDDED EEEEEEVSDS |
| Molecular Mass: | 18.8 kDa(160aa), confirmed by MALDI-TOF. |
| Applications: | SDS-PAGE |
| Storage: | Storeat 4 deg C for short term storage (1/2 weeks). Aliquot and store at -20 deg Cor - 70 deg C for long term storage. Avoid repeated freeze/thaw cycles. |
| OfficialSymbol: | SNIP1 |
| Pathways: | Regulation ofnuclear SMAD2/3 signaling; TGF-beta Receptor Signaling Pathway |
| Gene Name: | SNIP1 Smad nuclear interactingprotein 1 [ Homo sapiens ] |
| Synonyms: | SNIP1;Smad nuclear interacting protein 1; FLJ12553;dJ423B22.2; RP3-423B22.3; smad nuclear-interacting protein 1; FHAdomain-containing protein SNIP1; Smad nuclear interacting protein (SNIP1); Smad nuclear-interacting protein 1; OTTHUMP00000004404 |
| Gene ID: | 79753 |
| mRNA Refseq: | NM_024700 |
| Protein Refseq: | NP_078976 |
| MIM: | 608241 |
| UniProt ID: | Q8TAD8 |
| Chromosome Location: | 1p34.3 |
| Function: | proteinbinding |
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