| Cat. No. : |
SNIP1-5127H |
| Product Overview : |
Recombinant human SNIP1 protein,fused to His-tag at N-terminus, was expressed in E. coli and purified byusing conventional chromatography techniques. |
| Description : |
SNIP1 is smad nuclear interactingprotein contains a forkhead-associated (FHA) domain and acts as a nuclearinhibitor of CBP/p300. This protein is an inhibitor of the TGF-beta signaltransduction pathway and is important in suppressing transcriptionalactivation dependent on the co-activators CBP and p300. Inhibition ofNF-kappa B activity is a function of the N-terminal domain of SNIP1 andinvolves competition of SNIP1 and the NF-kappa B subunit, RelA/p65, for bindingto p300, similar to the mechanism of inhibition of Smad signaling by SNIP1. |
| Concentration : |
1 mg/ml |
| Source : |
Human |
| Host : |
E.coli |
| Form : |
Suppliedas a liquid in 20mM Tris-HCl buffer, pH 8.0, containing 2mM DTT, 20% glyceroland 100mM NaCl. |
| Purity : |
> 90% by SDS -PAGE |
| Sequence : |
258-396 amino acids:MGSSHHHHHH SSGLVPRGSH MRWRLYPFKN DEVLPVMYIH RQSAYLLGRH RRIADIPIDH PSCSKQHAVFQYRLVEYTRA DGTVGRRVKP YIIDLGSGNG TFLNNKRIEP QRYYELKEKD VLKFGFSSRE YVLLHESSDTSEIDRKDDED EEEEEEVSDS |
| Molecular Mass : |
18.8 kDa(160aa), confirmed by MALDI-TOF. |
| Applications : |
SDS-PAGE |
| Storage : |
Storeat 4 deg C for short term storage (1/2 weeks). Aliquot and store at -20 deg Cor - 70 deg C for long term storage. Avoid repeated freeze/thaw cycles. |
| OfficialSymbol : |
SNIP1 |
| Pathways : |
Regulation ofnuclear SMAD2/3 signaling; TGF-beta Receptor Signaling Pathway |
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.