"PTPN12" Related Products


Recombinant Human PTPN12, GST-tagged

Cat. No.: PTPN12-1858H
Product Overview: Recombinant human PTPN12 protein(2-300) with N-terminal GST tag was expressed in anE.coliexpression system, MW=61.4 kDa.
Description: Protein tyrosine phosphatase-PEST (PTPN12), a ubiquitously expressed cytoplasmic tyrosine phosphatase, is thought to play an important role in cell adhesion and motility, cell migration, and signal transduction for antigen receptors in B and T lymphocytes. Signal transduction via tyrosine phosphorylation, normally fine-tuned by the concerted action of both protein tyrosine kinases and protein tyrosine phosphatases (PTPs), is a key mechanism in tumorigenesis. Studies suggest potential role for PTP-PEST in regulation of p130(cas) in mitogen- and cell adhesion-induced signaling events.
Source: E.coli.
Formulation: 25 mM Tris-HCl, pH 8.0, 75 mM NaCl, 0.05% Tween-20, 50% glycerol, 2 mM EDTA, 1 mM DTT, 10 mM glutathione.
Purity: > 90% by SDS-PAGE.
Specific Activity: 1 U/ug. One unit will hydrolyze 1 nmol p-nitrophenyl phosphate per minute at pH 7.4 and 30ºC. Assay buffer: 50 mM HEPES, pH 7.4, 2 mM EDTA, 3 mM DTT, 100 mM NaCl, 50 mM pNPP.
Application: Useful for the study of enzyme kinetics, regulation, to dephosphorylate target substrates and for screening inhibitors.
Storage: >6 months at –80°C.
Gene Name: PTPN12 protein tyrosine phosphatase, non-receptor type 12 [ Homo sapiens ]
Synonyms: protein tyrosine phosphatase, non-receptor type 12; PTPG1; PTP-PEST; PTPN12; protein-tyrosine phosphatase G1; tyrosine-protein phosphatase non-receptor type 12; EC; OTTHUMP00000025119; Protein-tyrosine phosphatase G1
Gene ID: 5782
mRNA Refseq: NM_001131008
Protein Refseq: NP_001124480
MIM: 600079
UniProt ID: Q05209
Chromosome Location: 7q11.23
Function: SH3 domain binding; hydrolase activity; protein binding; non-membrane spanning protein tyrosine phosphatase activity

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