Recombinant Human PTPN9, GST-tagged

• Cat.No.: PTPN9-1857H
• Product Overview: Recombinant human PTPN9 protein(a.a.285-593) with N-terminal GST tag was expressed in anE.coliexpression system, MW=60.3 kDa.

Specification

• Cat. No.: PTPN9-1857H
• Description: Tyrosine-protein phosphatase non-receptor type 9 is an enzyme that in humans is encoded by the PTPN9 gene. The protein is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation.
• Source: E.coli.
• Formulation: 25 mM Tris-HCl, pH 8.0, 75 mM NaCl, 0.05% Tween-20, 50% glycerol, 2 mM EDTA, 1 mM DTT, 10 mM glutathione.
• Purity: > 70% by SDS-PAGE.
• Specific Activity: 2 U/ug. One unit will hydrolyze 1 nmol p-nitrophenyl phosphate per minute at pH 7.4 and 30°C. Assay buffer: 50 mM HEPES, pH 7.4, 2 mM EDTA, 3 mM DTT, 100 mM NaCl, 50 mM pNPP.
• Application: Useful for the study of enzyme kinetics, regulation, to dephosphorylate target substrates and for screening inhibitors.
• Storage: >6 months at –80°C.

Gene Information

• Gene Name: PTPN9 protein tyrosine phosphatase, non-receptor type 9 [ Homo sapiens ]
• Synonyms: protein tyrosine phosphatase, non-receptor type 9; MEG2; PTPMEG2; PTPN9; tyrosine-protein phosphatase non-receptor type 9; PTPase MEG2; PTPase-MEG2; protein-tyrosine phosphatase MEG2; EC 3.1.3.48
• Gene ID: 5780
• mRNA Refseq: NM_002833
• Protein Refseq: NP_002824
• MIM: 600768
• UniProt ID: P43378
• Chromosome Location: 15q24.2
• Function: hydrolase activity; non-membrane spanning protein tyrosine phosphatase activity; protein binding; protein tyrosine phosphatase activity