Native Human Serpin Peptidase Inhibitor, Clade A (alpha-1 antiproteinase, antitrypsin), Member 3

• Cat.No.: SERPINA3-5331H
• Product Overview: Native human SERPINA3 expressed by Human Plasma

Specification

• Description: SERPINA3is an alpha globulin glycoprotein that is a member of the serine proteinaseinhibitor (serpin) family. It inhibits the activity of certain proteinases,such as cathepsin G that are found in neutrophils, and chymases found in mastcells. This activity protects some tissues, such as the lower respiratorytract, from damage caused by proteolytic enzymes. SERPINA3 is produced in theliver, and is an acute phase protein that is induced during inflammationfound at concentrations of 45 mg/100 ml. Clinically, it is elevated ininflammatory conditions, some malignancies, Crohn"s disease, ulcerativecolitis, and burn injuries.
• Source: human plasma
• Species: Human
• Form: Lyophilized from 20mM Tris-HCl pH 7.4 + 150 mM NaCl.
• Purity: >95% by SDS-PAGE.
• Storage: Store at -70°C .

Gene Information

• Gene Name: SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 [ Homo sapiens ]
• Official Symbol: SERPINA3
• Synonyms: SERPINA3; serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3; AACT, alpha 1 antichymotrypsin , serine (or cysteine) proteinase inhibitor, clade A (alpha 1 antiproteinase, antitrypsin), member 3; alpha-1-antichymotrypsin
• Gene ID: 12
• mRNA Refseq: NM_001085
• Protein Refseq: NP_001076
• MIM: 107280
• UniProt ID: P01011
• Chromosome Location: 14q32.1
• Pathway: Selenium Pathway, organism-specific biosystem
• Function: DNA binding; peptidase inhibitor activity; protein binding; serine-type endopeptidase inhibitor activity; serine-type endopeptidase inhibitor activity