Recombinant Rat Vascular Endothelial Growth Factor C, His-tagged


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Recombinant Rat Vascular Endothelial Growth Factor C, His-tagged

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Cat. No. : Vegfc-5345R
Product Overview : Recombinantrat Vegfc contains129 amino acids and is fused to a His-tag (6x His) at theC-terminal end. As a result of glycosylation, Vegfc migratesas an 18-24 kDa protein in SDS-PAGE under reducingconditions.
Description : Theprotein encoded by this gene is a member of the platelet-derived growthfactor/vascular endothelial growth factor family, is active in angiogenesis, lymphangiogenesisand endothelial cell growth and survival, and can also affect thepermeability of blood vessels. This secreted protein undergoes a complexproteolytic maturation, generating multiple processed forms that bind andactivate VEGFR-3 receptors. Only the fully processed form can bind andactivate VEGFR-2 receptors. The structure and function of this protein issimilar to those of vascular endothelial growth factor D.
Source : Insect cells
Species : Human
Molecular Weight : 18-24 kDa
Endotoxin Level : < 0.1 ng/μgof the protein.
Form : Lyophilized from asterile filtered solution containing BSA.
Purity : > 90% bySDS-PAGE and visualized by silver stain.
Biological Activity : Measuredby its ability to stimulate phosphorylation of the VEGFR-3/FLT-4 receptor in pigaortic endothelial cells. The ED50 for this effect is typically 200-300ng/ml.
Reconstitution : Centrifugevial prior to opening. The lyophilized Vegfc issoluble in water and most aqueous buffers. The lyophilized Vegfc shouldbe reconstituted in PBS or medium to a concentrationnot lower than 50 μg/ml.
Storage : Lyophilizedsamples are stable for greater than six months at -20°C to -80°C. ReconstitutedVegfc shouldbe stored in working aliquots at -20°C. Avoid repeated freeze-thawcycles.
OfficialSymbol : Vegfc
Renderingbased on PDB 2X1W. :

Gene Name : Vegfc vascular endothelialgrowth factor C [ Rattus norvegicus ]
Synonyms : Vegfc; vascularendothelial growth factor C; vascular endothelial growth factor C; VRP;VEGF-C; flt4-L; flt4 ligand; vascular endothelial growth factor-relatedprotein
Gene ID : 114111
mRNA Refseq : NM_053653
Protein Refseq : NP_446105
UniProt ID : O35757
Chromosome Location : 16p11
Pathway : Bladder cancer;Cytokine-cytokine receptor interaction; Focal adhesion; Hemostasis;Pancreatic cancer; Pathways in cancer; Platelet activation; Plateletdegranulation; Renal cell carcinoma; Response to elevated platelet cytosolicCa2+; Signal Transduction; Signaling by VEGF; VEGF binds to VEGFR leading toreceptor dimerization; VEGF ligand-receptor interactions; VEGFR-3 signaling;mTOR signaling pathway
Function : chemoattractantactivity; growth factor activity; vascular endothelial growth factor receptor3 binding
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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