"Vegfc" Related Products


Recombinant Rat Vascular Endothelial Growth Factor C, His-tagged

Cat. No. : Vegfc-5345R
Product Overview : Recombinantrat Vegfc contains129 amino acids and is fused to a His-tag (6x His) at theC-terminal end. As a result of glycosylation, Vegfc migratesas an 18-24 kDa protein in SDS-PAGE under reducingconditions.
Description : Theprotein encoded by this gene is a member of the platelet-derived growthfactor/vascular endothelial growth factor family, is active in angiogenesis, lymphangiogenesisand endothelial cell growth and survival, and can also affect thepermeability of blood vessels. This secreted protein undergoes a complexproteolytic maturation, generating multiple processed forms that bind andactivate VEGFR-3 receptors. Only the fully processed form can bind andactivate VEGFR-2 receptors. The structure and function of this protein issimilar to those of vascular endothelial growth factor D.
Source : Insect cells
Species : Human
Molecular Weight : 18-24 kDa
Endotoxin Level : < 0.1 ng/μgof the protein.
Form : Lyophilized from asterile filtered solution containing BSA.
Purity : > 90% bySDS-PAGE and visualized by silver stain.
Biological Activity : Measuredby its ability to stimulate phosphorylation of the VEGFR-3/FLT-4 receptor in pigaortic endothelial cells. The ED50 for this effect is typically 200-300ng/ml.
Reconstitution : Centrifugevial prior to opening. The lyophilized Vegfc issoluble in water and most aqueous buffers. The lyophilized Vegfc shouldbe reconstituted in PBS or medium to a concentrationnot lower than 50 μg/ml.
Storage : Lyophilizedsamples are stable for greater than six months at -20°C to -80°C. ReconstitutedVegfc shouldbe stored in working aliquots at -20°C. Avoid repeated freeze-thawcycles.
OfficialSymbol : Vegfc
Gene Name : Vegfc vascular endothelialgrowth factor C [ Rattus norvegicus ]
Synonyms : Vegfc; vascularendothelial growth factor C; vascular endothelial growth factor C; VRP;VEGF-C; flt4-L; flt4 ligand; vascular endothelial growth factor-relatedprotein
Gene ID : 114111
mRNA Refseq : NM_053653
Protein Refseq : NP_446105
UniProt ID : O35757
Chromosome Location : 16p11
Pathway : Bladder cancer;Cytokine-cytokine receptor interaction; Focal adhesion; Hemostasis;Pancreatic cancer; Pathways in cancer; Platelet activation; Plateletdegranulation; Renal cell carcinoma; Response to elevated platelet cytosolicCa2+; Signal Transduction; Signaling by VEGF; VEGF binds to VEGFR leading toreceptor dimerization; VEGF ligand-receptor interactions; VEGFR-3 signaling;mTOR signaling pathway
Function : chemoattractantactivity; growth factor activity; vascular endothelial growth factor receptor3 binding

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