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Recombinant Rat Vascular Endothelial Growth Factor C, His-tagged

Cat. No.: Vegfc-5345R
Product Overview: Recombinantrat Vegfc contains129 amino acids and is fused to a His-tag (6x His) at theC-terminal end. As a result of glycosylation, Vegfc migratesas an 18-24 kDa protein in SDS-PAGE under reducingconditions.
Description: Theprotein encoded by this gene is a member of the platelet-derived growthfactor/vascular endothelial growth factor family, is active in angiogenesis, lymphangiogenesisand endothelial cell growth and survival, and can also affect thepermeability of blood vessels. This secreted protein undergoes a complexproteolytic maturation, generating multiple processed forms that bind andactivate VEGFR-3 receptors. Only the fully processed form can bind andactivate VEGFR-2 receptors. The structure and function of this protein issimilar to those of vascular endothelial growth factor D.
Source: Insect cells
Species: Human
Molecular Weight: 18-24 kDa
Endotoxin Level: < 0.1 ng/μgof the protein.
Form: Lyophilized from asterile filtered solution containing BSA.
Purity: > 90% bySDS-PAGE and visualized by silver stain.
Biological Activity: Measuredby its ability to stimulate phosphorylation of the VEGFR-3/FLT-4 receptor in pigaortic endothelial cells. The ED50 for this effect is typically 200-300ng/ml.
Reconstitution: Centrifugevial prior to opening. The lyophilized Vegfc issoluble in water and most aqueous buffers. The lyophilized Vegfc shouldbe reconstituted in PBS or medium to a concentrationnot lower than 50 μg/ml.
Storage: Lyophilizedsamples are stable for greater than six months at -20°C to -80°C. ReconstitutedVegfc shouldbe stored in working aliquots at -20°C. Avoid repeated freeze-thawcycles.
OfficialSymbol: Vegfc
Gene Name: Vegfc vascular endothelialgrowth factor C [ Rattus norvegicus ]
Synonyms: Vegfc; vascularendothelial growth factor C; vascular endothelial growth factor C; VRP;VEGF-C; flt4-L; flt4 ligand; vascular endothelial growth factor-relatedprotein
Gene ID: 114111
mRNA Refseq: NM_053653
Protein Refseq: NP_446105
UniProt ID: O35757
Chromosome Location: 16p11
Pathway: Bladder cancer;Cytokine-cytokine receptor interaction; Focal adhesion; Hemostasis;Pancreatic cancer; Pathways in cancer; Platelet activation; Plateletdegranulation; Renal cell carcinoma; Response to elevated platelet cytosolicCa2+; Signal Transduction; Signaling by VEGF; VEGF binds to VEGFR leading toreceptor dimerization; VEGF ligand-receptor interactions; VEGFR-3 signaling;mTOR signaling pathway
Function: chemoattractantactivity; growth factor activity; vascular endothelial growth factor receptor3 binding

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Optional requirements on this protein    +Expand
C-fusion    N-fusion   Non-tagged
His    GST   Fc   Others
<1.0 eu/μg    <0.1 eu/μg   <0.01 eu/μg   Not required
Monomer Isolation    Dimer Isolation    Not required
>80% by SDS-PAGE    >90% by SDS-PAGE   >95% by SDS-PAGE   Others

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