Recombinant Human Insulin


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Recombinant Human Insulin

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Cat. No. : INS-5308H
Product Overview : Recombinant HumanInsulin is a two chain, non-glycosylated polypeptide chain containing 51amino acids and has a MW = 5.8 kDa.
Description : INS is a hormonecentral to regulating carbohydrate and fat metabolism in the body. INS causescells in the liver, muscle, and fat tissue to take up glucose from the blood,storing it as glycogen in the liver and muscle. INS stops the use of fat asan energy source by inhibiting the release of glucagon. With the exception ofthe metabolic disorder diabetes mellitus and Metabolic syndrome, INS isprovided within the body in a constant proportion to remove excess glucosefrom the blood, which otherwise would be toxic.
Source : E. coli
Species : Human
Form : Lyophilized from asterile, concentrated (1 mg/ml) solution with no additives.
Molecular Weight : 5.8 kDa
Purity : >98.0% asdetermined by RP-HPLC and SDS-PAGE.
Endotoxin Level : <0.1 ng/µg ofrecombinant human Insulin
Biological Activity : 28 units/mg
Reconstitution : Centrifuge vialprior to opening. Add sterile 0.005 N HCL to the vial to fully solubilize theprotein to a concentration not more than 1 mg/ml.
Storage : Lyophilized productis stable at room temperature for 3 weeks, but it is recommended to store thelyophilized product desiccated at -20°C to -80°C. Upon reconstitution,protein should be stored at 2-4°C for one week and for future use at -20°C to-80°C. Add a carrier protein (0.1% HSA or BSA) as a stabilizer for long termstorage. Please note that the addition of any carrier protein into thisproduct may produce unwanted endotoxin. This depends upon the particularapplication employed. Avoid repeated freeze-thaw cycles.
OfficialSymbol : INS
Computer-generatedimage of six insulin molecules assembled in a hexamer, highlighting thethreefold symmetry, the zinc ions holding it together, and the histidineresidues involved in zinc binding. Insulin is stored in the body as ahexamer, while the active form is the monomer. :

Gene Name : INS insulin [ Homo sapiens]
Synonyms : INS; insulin; ILPR;IRDN; IDDM2; MODY10; proinsulin; OTTHUMP00000011161; OTTHUMP00000011162;OTTHUMP00000196036; OTTHUMP00000196038; OTTHUMP00000217519
Gene ID : 3630
mRNA Refseq : NM_000207
Protein Refseq : NP_000198
MIM : 176730
UniProt ID : P01308
Chromosome Location : 11p15.5
Pathway : ATF-2 transcriptionfactor network; Adipogenesis; Arf6 trafficking events; Diabetes pathways;FOXA2 and FOXA3 transcription factor networks; Folate Metabolism; IRS activation;Insulin receptor recycling; Insulin signaling pathway; Maturity onsetdiabetes of the young; Progesterone-mediated oocyte maturation; Regulation ofInsulin Secretion; SHC-related events; Type I diabetes mellitus; mTORsignaling pathway
Function : hormone activity;insulin receptor binding; insulin-like growth factor receptor binding;protein binding
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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