Native Human Kininogen 1

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Native Human Kininogen 1

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Cat. No. : KNG1-1844H
Product Overview : Native human KNG1 was purifiedin Human plasma. MW 120 kDa.
Description : HumanKNG1, two chain form HMW, is prepared by digestion of single chain KNG1. Kininogen-1(KNG1), also known as alpha-2-thiol proteinase inhibitor,Williams-Fitzgerald-Flaujeac factor or the HMWK-kallikrein factor, is aprotein that in humans is encoded by the KNG1 gene.
Form : Frozen liquid in 4mM Sodium Acetate Buffer + 0.15 M NaCl, pH 5.3.
Source : Human plasma
Molecule Weight : 120 kDa
Purity : >95% by SDS-PAGEanalysis.
Endotoxin Level : < 0.1 ng/µg ofprotein.
Concentration : 2.0 mg/ml
Storage : Store at -80°C.Stable for 3 years from delivery. Avoid repeated freeze-thaw cycles.
Pathways : ACEInhibitor Pathway; Class A/1 (Rhodopsin-like receptors); Complement andCoagulation Cascades; Formation of Fibrin Clot (Clotting Cascade); G alpha(i) signalling events; GPCR downstream signaling; GPCR ligand binding;Hemostasis; Intrinsic Pathway; Peptide ligand-binding receptors; Plateletactivation; Platelet degranulation; Response to elevated platelet cytosolicCa2+; Signal Transduction; Signaling by GPCR; Syndecan-2-mediated signalingevents; amb2 Integrin signaling
Publication : Stable and Long-Lasting, Novel Bicyclic Peptide Plasma Kallikrein Inhibitors for the Treatment of Diabetic Macular Edema
Gene Name : KNG1 kininogen 1 [ Homosapiens ]
Official Symbol : KNG1
Synonyms : KNG1; kininogen 1; BDK; KNG;kininogen-1; HMWK; bradykinin; fitzgerald factor; OTTHUMP00000197128;OTTHUMP00000197129; OTTHUMP00000210109; high molecular weight kininogen;alpha-2-thiol proteinase inhibitor; williams-Fitzgerald-Flaujeac factor;Alpha-2-thiol proteinase inhibitor; Fitzgerald factor; High molecular weightkininogen; Williams-Fitzgerald-Flaujeac factor
Gene ID : 3827
mRNA Refseq : NM_000893
Protein Refseq : NP_000884
MIM : 612358
UniProt ID : P01042
Chromosome Location : 3q27
Function : cysteine-typeendopeptidase inhibitor activity; heparin binding; peptidase inhibitoractivity; receptor binding; zinc ion binding

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