Native Human Kininogen 1

• Cat.No.: KNG1-1844H
• Product Overview: Native human KNG1 was purifiedin Human plasma. MW 120 kDa.

Specification

• Cat. No.: KNG1-1844H
• Description: HumanKNG1, two chain form HMW, is prepared by digestion of single chain KNG1. Kininogen-1(KNG1), also known as alpha-2-thiol proteinase inhibitor,Williams-Fitzgerald-Flaujeac factor or the HMWK-kallikrein factor, is aprotein that in humans is encoded by the KNG1 gene.
• Form: Frozen liquid in 4mM Sodium Acetate Buffer + 0.15 M NaCl, pH 5.3.
• Source: Human plasma
• Molecule Weight: 120 kDa
• Purity: >95% by SDS-PAGEanalysis.
• Endotoxin Level: < 0.1 ng/µg ofprotein.
• Concentration: 2.0 mg/ml
• Storage: Store at -80°C.Stable for 3 years from delivery. Avoid repeated freeze-thaw cycles.
• Pathways: ACEInhibitor Pathway; Class A/1 (Rhodopsin-like receptors); Complement andCoagulation Cascades; Formation of Fibrin Clot (Clotting Cascade); G alpha(i) signalling events; GPCR downstream signaling; GPCR ligand binding;Hemostasis; Intrinsic Pathway; Peptide ligand-binding receptors; Plateletactivation; Platelet degranulation; Response to elevated platelet cytosolicCa2+; Signal Transduction; Signaling by GPCR; Syndecan-2-mediated signalingevents; amb2 Integrin signaling
• Publication:
  Stable and Long-Lasting, Novel Bicyclic Peptide Plasma Kallikrein Inhibitors for the Treatment of Diabetic Macular Edema (2018)

Gene Information

• Gene Name: KNG1 kininogen 1 [ Homosapiens ]
• Official Symbol: KNG1
• Synonyms: KNG1; kininogen 1; BDK; KNG;kininogen-1; HMWK; bradykinin; fitzgerald factor; OTTHUMP00000197128;OTTHUMP00000197129; OTTHUMP00000210109; high molecular weight kininogen;alpha-2-thiol proteinase inhibitor; williams-Fitzgerald-Flaujeac factor;Alpha-2-thiol proteinase inhibitor; Fitzgerald factor; High molecular weightkininogen; Williams-Fitzgerald-Flaujeac factor
• Gene ID: 3827
• mRNA Refseq: NM_000893
• Protein Refseq: NP_000884
• MIM: 612358
• UniProt ID: P01042
• Chromosome Location: 3q27
• Function: cysteine-typeendopeptidase inhibitor activity; heparin binding; peptidase inhibitoractivity; receptor binding; zinc ion binding