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Recombinant Human UBE2D3

Cat. No.: UBE2D3-1882H
Product Overview: Recombinant Human UBE2D3 was expressed inE.Coli.
Description: UBE2D3 enzymes are human homologs of the yeast UBC4/5 family and play many important regulatory roles in inflammation and cancer. UbcH5a mediates the degradation of a myriad of short-lived regulatory proteins (such as p53 in the presence of E6/E6-AP or MDM2, c-Fos, IκBα, p105) and abnormal proteins. UBE2D3 has 88% and 89% sequence identity with UbcH5a and UbcH5b respectively.
Source: Escherichia Coli.
Amino Acid Sequence: MHHHHHHAM ALKRINKELSDLA RDPPAQCSAGPV GDDMF HWQATIMGP NDSPYQGGVFFLTIHFPTD YPFKPPKVAFTTRIY HPNINSNGSI CLDILRS QWSPALTISK VLLSICSLLCDPNPDDPL.
Physical Appearance: Sterile Filtered white lyophilized powder.
Purity: Greater than 95.0% as determined by:(a) Analysis by RP-HPLC.(b) Analysis by SDS-PAGE.
Formulation: Lyophilized from a 0.2μm filtered concentrated (1 mg/ml) solution in 1X PBS and 1mM DTT, pH 7.5.
Stability: Lyophilized UBE2D3 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution UBE2D3 should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles.
Gene Name: UBE2D3 ubiquitin-conjugating enzyme E2D 3 (UBC4/5 homolog, yeast) [ Homo sapiens ]
Synonyms: ubiquitin-conjugating enzyme E2D 3 (UBC4/5 homolog, yeast); UBC4/5; UBCH5C; MGC5416; MGC43926; E2(17)KB3; UBE2D3; ubiquitin-conjugating enzyme E2 D3; E2(17)KB 3; ubiquitin-protein ligase D3; ubiquitin carrier protein D3; ubiquitin-conjugating enzyme E2-17 kDa 3;ubiquitin-conjugating enzyme E2D 3 (homologous to yeast UBC4/5); Ubiquitin-conjugating enzyme E2-17 kDa 3; UbcH5C; EC 6.3.2.19; Ubiquitin-protein ligase D3; Ubiquitin carrier protein D3
Gene ID: 7323
mRNA Refseq: NM_003340.5
Protein Refseq: NP_003331.1
MIM: 602963
UniProt ID: P61077
Chromosome Location: 4q24
Pathway: Ubiquitin mediated proteolysis; Signaling by BMP; Signaling by TGF beta
Function: ATP binding; ligase activity; nucleotide binding; protein binding; ubiquitin-protein ligase activity

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