"ULK1" Related Products

Expand

Recombinant Human ULK1 protein, FLAG-tagged

Cat.No. : ULK1-568H
Product Overview : Recombinant Human ULK1(2–end) fused with FLAG tag at N-terminal was expressed in FreeStyle 293-F cells.
Description : ULK1 is a serine/threonine protein kinase that plays critical role during initial stages of autophagy which is a vital response to nutrient starvation. The conserved C-terminal domain (CTD) of ULK1 controls the regulatory function and localization of the protein. Knockdown of ULK1 inhibits the autophagic response as well as inhibiting rapamycin-induced autophagy consistent with a role downstream of mTOR. ULK1 forms a complex with FIP200 and ATG13 and this complex is essential for starvation-induced autophagy. Both FIP200 and ATG13 are critical for correct localization of ULK1 to the pre-autophagosome and stability of ULK1 protein. ULK1 is phosphorylated by the mTOR pathway in a nutrient starvation-regulated manner.
Source : FreeStyle 293-F cells
Species : Human
Tag : FLAG
Form : Aqueous buffer solution
Molecular Mass : 113 kDa
Purity : 0.4
Applications : Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.
Stability : >6 months at -80 centigrade. Avoid freeze/thaw cycles.
Gene Name : ULK1 unc-51-like kinase 1 (C. elegans) [ Homo sapiens ]
Official Symbol : ULK1
Synonyms : ULK1; unc-51-like kinase 1 (C. elegans); unc 51 (C. elegans) like kinase 1; serine/threonine-protein kinase ULK1; ATG1; ATG1 autophagy related 1 homolog (S. cerevisiae); ATG1A; ATG1 autophagy related 1 homolog; autophagy-related protein 1 homolog; UNC51; hATG1; Unc51.1; FLJ38455; FLJ46475;
Gene ID : 8408
mRNA Refseq : NM_003565
Protein Refseq : NP_003556
MIM : 603168
UniProt ID : O75385
Chromosome Location : 12q24.3
Pathway : Regulation of autophagy, organism-specific biosystem; Regulation of autophagy, conserved biosystem; Senescence and Autophagy, organism-specific biosystem; mTOR signaling pathway, organism-specific biosystem; mTOR signaling pathway, conserved biosystem;
Function : ATP binding; nucleotide binding; protein binding; protein complex binding; protein serine/threonine kinase activity; protein serine/threonine kinase activity;

Online Inquiry

Note: There will be extra charge for optional service!

Please input "biomart" as verification code. Please review Creative BioMart's privacy policy for more information

Optional requirements on this protein    +Expand

Price Inquiry

Welcome! For price inquiries, please feel free to contact us through the form below. We will get back to you as soon as possible.