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Recombinant Human ULK1 protein, FLAG-tagged

Cat.No. : ULK1-568H
Product Overview : Recombinant Human ULK1(2–end) fused with FLAG tag at N-terminal was expressed in FreeStyle 293-F cells.
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Description : ULK1 is a serine/threonine protein kinase that plays critical role during initial stages of autophagy which is a vital response to nutrient starvation. The conserved C-terminal domain (CTD) of ULK1 controls the regulatory function and localization of the protein. Knockdown of ULK1 inhibits the autophagic response as well as inhibiting rapamycin-induced autophagy consistent with a role downstream of mTOR. ULK1 forms a complex with FIP200 and ATG13 and this complex is essential for starvation-induced autophagy. Both FIP200 and ATG13 are critical for correct localization of ULK1 to the pre-autophagosome and stability of ULK1 protein. ULK1 is phosphorylated by the mTOR pathway in a nutrient starvation-regulated manner.
Source : FreeStyle 293-F cells
Species : Human
Tag : FLAG
Form : Aqueous buffer solution
Molecular Mass : 113 kDa
Purity : 0.4
Applications : Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.
Stability : >6 months at -80 centigrade. Avoid freeze/thaw cycles.
Gene Name : ULK1 unc-51-like kinase 1 (C. elegans) [ Homo sapiens ]
Official Symbol : ULK1
Synonyms : ULK1; unc-51-like kinase 1 (C. elegans); unc 51 (C. elegans) like kinase 1; serine/threonine-protein kinase ULK1; ATG1; ATG1 autophagy related 1 homolog (S. cerevisiae); ATG1A; ATG1 autophagy related 1 homolog; autophagy-related protein 1 homolog; UNC51; hATG1; Unc51.1; FLJ38455; FLJ46475;
Gene ID : 8408
mRNA Refseq : NM_003565
Protein Refseq : NP_003556
MIM : 603168
UniProt ID : O75385
Chromosome Location : 12q24.3
Pathway : Regulation of autophagy, organism-specific biosystem; Regulation of autophagy, conserved biosystem; Senescence and Autophagy, organism-specific biosystem; mTOR signaling pathway, organism-specific biosystem; mTOR signaling pathway, conserved biosystem;
Function : ATP binding; nucleotide binding; protein binding; protein complex binding; protein serine/threonine kinase activity; protein serine/threonine kinase activity;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (7)

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How does ULK1 interact with other autophagy-related proteins? 03/01/2021

ULK1 interacts with several autophagy-related proteins, including ATG13, FIP200, and ATG101, forming a complex that is essential for the initiation of autophagy.

Are there any known upstream regulators of ULK1 activity? 09/02/2019

mTOR (mechanistic target of rapamycin) is a known upstream regulator of ULK1. When nutrients are abundant, mTOR is active and inhibits ULK1. Conversely, under nutrient starvation, mTOR is inactivated, leading to ULK1 activation and initiation of autophagy.

What is the primary function of the ULK1 protein in cellular processes? 07/27/2019

ULK1 is a serine/threonine-protein kinase that plays a crucial role in the initiation of autophagy, a cellular process responsible for the degradation and recycling of cellular components.

What are the implications of ULK1 dysregulation in diseases like cancer? 07/07/2019

Dysregulation of ULK1 can lead to impaired autophagy, which has been implicated in several diseases, including cancer. Overactive or underactive ULK1 can disrupt cellular homeostasis and contribute to tumorigenesis.

Are there any known post-translational modifications of ULK1 that influence its activity? 01/02/2019

ULK1 undergoes several post-translational modifications, including phosphorylation and ubiquitination, which can either activate or inhibit its kinase activity and, consequently, its role in autophagy.

How does ULK1 play a role in the initiation of autophagy? 09/29/2018

ULK1 is part of a complex that is essential for the initiation of autophagy. Upon activation, ULK1 phosphorylates several targets, leading to the nucleation and formation of the autophagosome.

How does ULK1 activity relate to nutrient availability in cells? 07/06/2018

ULK1 activity is sensitive to nutrient availability. Under nutrient-rich conditions, ULK1 is inhibited, while under nutrient-deprived conditions, ULK1 becomes activated, promoting autophagy to recycle cellular components and generate energy.

Customer Reviews (3)

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Reviews
08/06/2022

    Reliable results, will reorder.

    06/07/2021

      Affordable and high-quality.

      09/30/2019

        Met all my expectations.

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