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Recombinant Human MHC Class I Polypeptide-Related Sequence B

Cat.No. : MICB-5194H
Product Overview : Recombinant HumanMICB has 326 amino acid residues containing the extracellular domain ofmature human MICB (amino acid residues Ala23-Tyr312).
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  • Gene Information
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Cat. No. : MICB-5194H
Description : This gene encodes aheavily glycosylated protein which is a ligand for the NKG2D type IIreceptor. Binding of the ligand activates the cytolytic response of naturalkiller (NK) cells, CD8 alphabeta T cells, and gammadelta T cells which expressthe receptor. This protein is stress-induced and is similar to MHC class Imolecules; however, it does not associate with beta-2-microglobulin or bindpeptides.
Source : Human
Host : E. coli
Form : Lyophilized from a0.2 μm sterile filtered solution of PBS, pH 7.0.
Purity : >95% by SDS-PAGEand HPLC analyses.
Molecular Weight : 37 kDa
Biological Activity : Measured by itsability to bind MICB antibody in an ELISA.
Endotoxin : < 0.1 ng/μg
Reconstitution : Centrifugevial prior to opening. Add sterile distilled water or aqueousbuffer containing 0.1% BSA to a concentration of 0.1-1.0 mg/ml. Please notethat the addition of any carrier protein into this product may produceunwanted endotoxin. This depends upon the particular application employed. Furtherdilutions should be made in appropriate buffered solutions.
Storage : Stable at2-8°C, but best kept desiccated -20°C. Upon reconstitution, stable for up to1 week at 2-8°C. For longer term, store in working aliquots below -20°C. Avoidrepeated freeze/thaw cycles.
OfficialSymbol : MICB
Pathways : Adaptive ImmunitySignaling, Immune System, Immunoregulatory interactions between a Lymphoidand a non-Lymphoid cell, Natural killer cell mediated cytotoxicity
Gene Name : MICB MHCclass I polypeptide-related sequence B [ Homo sapiens ]
Synonyms : MICB; MHC class Ipolypeptide-related sequence B; PERB11.2; MICB; MIC-B; OTTHUMP00000029089;MHC class I polypeptide-related sequence B; MHC class I molecule; MHC class Imic-B antigen; stress inducible class I homolog; MHC class I chain-relatedprotein B; MHC class I-like molecule PERB11.2-IMX; OTTHUMP00000035091;TTHUMP00000035588
Gene ID : 4277
mRNA Refseq : NM_005931
Protein Refseq : NP_005922
MIM : 602436
UniProt ID : Q29980
Chromosome Location : 6p21.3
Function : natural killer celllectin-like receptor binding

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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