Recombinant Human MHC Class I Polypeptide-Related Sequence B

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Recombinant Human MHC Class I Polypeptide-Related Sequence B

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Cat. No. : MICB-5194H
Product Overview : Recombinant HumanMICB has 326 amino acid residues containing the extracellular domain ofmature human MICB (amino acid residues Ala23-Tyr312).
Description : This gene encodes aheavily glycosylated protein which is a ligand for the NKG2D type IIreceptor. Binding of the ligand activates the cytolytic response of naturalkiller (NK) cells, CD8 alphabeta T cells, and gammadelta T cells which expressthe receptor. This protein is stress-induced and is similar to MHC class Imolecules; however, it does not associate with beta-2-microglobulin or bindpeptides.
Source : Human
Host : E. coli
Form : Lyophilized from a0.2 μm sterile filtered solution of PBS, pH 7.0.
Purity : >95% by SDS-PAGEand HPLC analyses.
Molecular Weight : 37 kDa
Biological Activity : Measured by itsability to bind MICB antibody in an ELISA.
Endotoxin : < 0.1 ng/μg
Reconstitution : Centrifugevial prior to opening. Add sterile distilled water or aqueousbuffer containing 0.1% BSA to a concentration of 0.1-1.0 mg/ml. Please notethat the addition of any carrier protein into this product may produceunwanted endotoxin. This depends upon the particular application employed. Furtherdilutions should be made in appropriate buffered solutions.
Storage : Stable at2-8°C, but best kept desiccated -20°C. Upon reconstitution, stable for up to1 week at 2-8°C. For longer term, store in working aliquots below -20°C. Avoidrepeated freeze/thaw cycles.
OfficialSymbol : MICB
Pathways : Adaptive ImmunitySignaling, Immune System, Immunoregulatory interactions between a Lymphoidand a non-Lymphoid cell, Natural killer cell mediated cytotoxicity
PDBrendering based on 1je6. :

Gene Name : MICB MHCclass I polypeptide-related sequence B [ Homo sapiens ]
Synonyms : MICB; MHC class Ipolypeptide-related sequence B; PERB11.2; MICB; MIC-B; OTTHUMP00000029089;MHC class I polypeptide-related sequence B; MHC class I molecule; MHC class Imic-B antigen; stress inducible class I homolog; MHC class I chain-relatedprotein B; MHC class I-like molecule PERB11.2-IMX; OTTHUMP00000035091;TTHUMP00000035588
Gene ID : 4277
mRNA Refseq : NM_005931
Protein Refseq : NP_005922
MIM : 602436
UniProt ID : Q29980
Chromosome Location : 6p21.3
Function : natural killer celllectin-like receptor binding

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