Recombinant Human Tumor Necrosis Factor Receptor Superfamily, Member 13C TNFRSF13C-5255H

Recombinant Human Tumor Necrosis Factor Receptor Superfamily, Member 13C

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Recombinant Human Tumor Necrosis Factor Receptor Superfamily, Member 13C

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Cat. No. : TNFRSF13C-5255H
Product Overview : Recombinant human TNFRSF13C is adisulfide-linked monomeric protein consisting of 76 amino acid residuesubunits. The molecule has a calculated molecular mass of approximately 9 kDaand migrates as an approximately 9 kDa protein under non-reducing andreducing conditions in SDS-PAGE.
Description : TNFRSF13C appears to be particularly important for the regulation of Bcell survival and maturation in the spleen, because A/WySnJ mice expressing adefective TNFRSF13C have disrupted B cell maturation, similar to that seen inBAFF-deficient mice.
Source : Human
Host : E. coli
Form : RecombinantTNFRSF13C was lyophilized from a 0.2 μm filtered solution in 2.5%glycine, 0.5% sucrose, 0.01% Tween80, 5 mM Glutamic acid, pH 4.5.
Purity : >95%, asdetermined by SDS-PAGE and HPLC.
Sequence : MRRGPRSLRG RDAPAPTPCV PAECFDLLVR HCVACGLLRT PRPKPAGASS PAPRTALQPQ ESVGAGAGEA ALPLPGLL
Molecular Weight : 9 kDa.
Biological Activity : TheED(50) was determined by the ability to block BAFF induced survival ofsplenocyte cells, and was found to be in the range of 1.0-5.0 ug/ml.
Endotoxin : Less than 0.1 ng/µg (1EU/µg).
Reconstitution : A quick spin of thevial followed by reconstitution in distilled water to a concentration notless than 0.1 mg/ml. This solution can then be diluted into other buffers.
Storage : The lyophilizedprotein is stable for at least 2 years from date of receipt at -20°C. Uponreconstitution, this cytokine can be stored in working aliquots at 2°C - 8°Cfor one month, or at -20°C for six months, with a carrier protein withoutdetectable loss of activity. Avoid repeated freeze/thaw cycles.
OfficialSymbol : TNFRSF13C
Pathways : Cytokine-cytokine receptorinteraction
PDBrendering based on 1oqe. :

Gene Name : TNFRSF13C tumor necrosisfactor receptor superfamily, member 13C [ Homo sapiens ]
Synonyms : TNFRSF13C; tumor necrosisfactor receptor superfamily, member 13C; CD268; MGC138235; BAFF receptor;OTTHUMP00000028746; B cell-activating factor receptor; BAFF-R; BAFFR; BR3;BLyS receptor 3; CD268 antigen; tumor necrosis factor receptor superfamily,member 13C
Gene ID : 115650
mRNA Refseq : NM_052945
Protein Refseq : NP_443177
MIM : 606269
UniProt ID : Q5H8V1
Chromosome Location : 22q13.1-q13.31
Function : receptor activity

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