Recombinant Human Tumor Necrosis Factor Receptor Superfamily, Member 13C

• Cat.No.: TNFRSF13C-5255H
• Product Overview: Recombinant human TNFRSF13C is adisulfide-linked monomeric protein consisting of 76 amino acid residuesubunits. The molecule has a calculated molecular mass of approximately 9 kDaand migrates as an approximately 9 kDa protein under non-reducing andreducing conditions in SDS-PAGE.

Specification

• Species: Human
• Source: Human
• Tag: Non
• Description: TNFRSF13C appears to be particularly important for the regulation of Bcell survival and maturation in the spleen, because A/WySnJ mice expressing adefective TNFRSF13C have disrupted B cell maturation, similar to that seen inBAFF-deficient mice.
• Form: RecombinantTNFRSF13C was lyophilized from a 0.2 μm filtered solution in 2.5%glycine, 0.5% sucrose, 0.01% Tween80, 5 mM Glutamic acid, pH 4.5.
• Purity: >95%, asdetermined by SDS-PAGE and HPLC.
• Sequence: MRRGPRSLRG RDAPAPTPCV PAECFDLLVR HCVACGLLRT PRPKPAGASS PAPRTALQPQ ESVGAGAGEA ALPLPGLL
• Molecular Weight: 9 kDa.
• Biological Activity: TheED(50) was determined by the ability to block BAFF induced survival ofsplenocyte cells, and was found to be in the range of 1.0-5.0 ug/ml.
• Endotoxin: Less than 0.1 ng/µg (1EU/µg).
• Reconstitution: A quick spin of thevial followed by reconstitution in distilled water to a concentration notless than 0.1 mg/ml. This solution can then be diluted into other buffers.
• Storage: The lyophilizedprotein is stable for at least 2 years from date of receipt at -20°C. Uponreconstitution, this cytokine can be stored in working aliquots at 2°C - 8°Cfor one month, or at -20°C for six months, with a carrier protein withoutdetectable loss of activity. Avoid repeated freeze/thaw cycles.
• OfficialSymbol: TNFRSF13C
• Pathways: Cytokine-cytokine receptorinteraction

Gene Information

• Gene Name: TNFRSF13C tumor necrosisfactor receptor superfamily, member 13C [ Homo sapiens ]
• Synonyms: TNFRSF13C; tumor necrosisfactor receptor superfamily, member 13C; CD268; MGC138235; BAFF receptor;OTTHUMP00000028746; B cell-activating factor receptor; BAFF-R; BAFFR; BR3;BLyS receptor 3; CD268 antigen; tumor necrosis factor receptor superfamily,member 13C
• Gene ID: 115650
• mRNA Refseq: NM_052945
• Protein Refseq: NP_443177
• MIM: 606269
• UniProt ID: Q5H8V1
• Chromosome Location: 22q13.1-q13.31
• Function: receptor activity