"DUSP10" Related Products

Expand
Expand

Recombinant Human Dual Specificity Phosphatase 10, His-tagged

Cat. No.: DUSP10-1392H
Product Overview: Recombinant humanDUSP10 protein, fused to His-tag at N-terminus, was expressed in E. coli andpurified by using conventional chromatography techniques.
Description: DUSP10 (Dualspecificity protein phosphatase 10) belongs to the protein-tyrosinephosphatase family. Dual specificity protein phosphatases(DUSPs) inactivatetheir target kinases by dephosphorylating both the phosphoserine/threonineand phosphotyrosine residues. They negatively regulate members of the MAPKsuperfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellularproliferation and differentiation. DUSP10 has been shown to interact withMAPK14 and MAPK8. When expressed in mammalian cells, DUSP10 blocks theenzymatic activation of MAP kinases with the selectivity p38 approximatelyJNK/SAPK >> ERK.
Form: Liquid. In 20mMTris-HCl buffer (pH 8.0) containing 2mM DTT, 50% glycerol, 200mM NaCl.
Molecular Weight: 40.4kDa(359aa), confirmed by MALDI-TOF.
Purity: > 90%by SDS - PAGE
Concentration: 0.25 mg/ml(determined by Bradford assay)
Sequences of aminoacids: MGSSHHHHHHSSGLVPRGSH MGSHMIIYPN DLAKKMTKCS KSHLPSQGPV IIDCRPFMEYNKSHIQGAVH INCADKISRR RLQQGKITVLDLISCREGKD SFKRIFSKEI IVYDENTNEP SRVMPSQPLHIVLESLKREG KEPLVLKGGL SSFKQNHENL CDNSLQLQEC REVGGGASAA SSLLPQPIPT TPDIENAELTPILPFLFLGN EQDAQDLDTM QRLNIGYVIN VTTHLPLYHY EKGLFNYKRL PATDSNKQNL RQYFEEAFEFIEEAHQCGKG LLIHCQAGVS RSATIVIAYL MKHTRMTMTD AYKFVKGKRP IISPNLNFMG QLLEFEEDLNNGVTPRILTP KLMGVETVV
Storage: Can bestored at +4°C short term (1-2 weeks). For long term storage, aliquot andstore at -20°C or -70°C. Avoid repeated freezing and thawing cycles.
Gene Name: DUSP10 dual specificityphosphatase 10 [ Homo sapiens ]
Official Symbol: DUSP10
Synonyms: DUSP10; dual specificity phosphatase 10;MKP5; MKP-5; dual specificity protein phosphatase 10; OTTHUMP00000035380; mapkinase phosphatase 5; dual specificity phosphatase MKP-5; serine/threoninespecific protein phosphatase; mitogen-activated protein kinase phosphatase 5;EC 3.1.3.16; EC 3.1.3.48
Gene ID: 11221
mRNA Refseq: NM_007207
Protein Refseq: NP_009138
MIM: 608867
UniProt ID: Q9Y6W6
Chromosome Location: 1q41
Pathway: ATF-2 transcription factor network; MAPKsignaling pathway; Regulation of p38-alpha and p38-beta
Function: MAP kinase tyrosine/serine/threoninephosphatase activity; hydrolase activity; phosphoprotein phosphataseactivity; protein tyrosine phosphatase activity

Online Inquiry

Note: There will be extra charge for optional service!
Optional requirements on this protein    +Expand
C-fusion    N-fusion   Non-tagged
His    GST   Fc   Others
<1.0 eu/μg    <0.1 eu/μg   <0.01 eu/μg   Not required
Monomer Isolation    Dimer Isolation    Not required
>80% by SDS-PAGE    >90% by SDS-PAGE   >95% by SDS-PAGE   Others

Please input "biomart" as verification code. Please review Creative BioMart's privacy policy for more information


Price does not include shipping and packaging costs.Request quote for final price.

Price Inquiry

Welcome! For price inquiries, please feel free to contact us through the form below. We will get back to you as soon as possible.