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Recombinant Human Gamma-Glutamyl Hydrolase (conjugase, folylpolygammaglutamyl hydrolase), His-tagged

Cat. No.: GGH-1399H
Product Overview: Recombinanthuman GGHprotein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventionalchromatography techniques.
Description: GGH is a homodimericprotein that catalyzes the cleavage of the gamma-glutamyl chain offolylpoly-gamma-glutamyl substrates and is a central enzyme in folyl andantifolyl poly-gamma-glutamate metabolism. GGH may play an important role inthe bioavailability of dietary pteroylpolyglutamates and in the metabolism ofpteroylpolyglutamates and antifolates.
Form: Liquid. In 20mMTris-HCl buffer (pH 8.0) containing 1mM DTT, 10% glycerol, 0.1M NaCl.
Molecular Weight: 35.9 kDa(315aa), confirmed by MALDI-TOF.
Purity: > 95%by SDS-PAGE
Concentration: 0.5mg/ml(determined by Bradford assay)
Sequences of aminoacids: MGSSHHHHHHSSGLVPRGSH MRPHGDTAKK PIIGILMQKC RNKVMKNYGR YYIAASYVKY LESAGARVVPVRLDLTEKDY EILFKSINGI LFPGGSVDLR RSDYAKVAKI FYNLSIQSFDDGDYFPVWGT CLGFEELSLL ISGECLLTAT DTVDVAMPLN FTGGQLHSRM FQNFPTELLL SLAVEPLTANFHKWSLSVKN FTMNEKLKKF FNVLTTNTDG KIEFISTMEG YKYPVYGVQW HPEKAPYEWK NLDGISHAPNAVKTAFYLAEFFVNEARKNNHHFKSESEEE KALIYQFSPI YTGNISSFQQ CYIFD
Storage: Can bestored at +4°C short term (1-2 weeks). For long term storage, aliquot andstore at -20°C or -70°C. Avoid repeated freezing and thawing cycles.
OfficialSymbol: GGH
nullValue_other:
PathwaysFluoropyrimidineActivity; Folate biosynthesis
Gene Name: GGH gamma-glutamyl hydrolase(conjugase, folylpolygammaglutamyl hydrolase) [ Homo sapiens ]
Synonyms: GGH; gamma-glutamyl hydrolase (conjugase,folylpolygammaglutamyl hydrolase); GH; gamma-glutamyl hydrolase; gamma-Glu-Xcarboxypeptidase; OTTHUMP00000226541; EC 3.4.19.9; Gamma-glutamyl hydrolase; Conjugase; Gamma-Glu-Xcarboxypeptidase; OTTHUMP00000226541; OTTHUMP00000226558
Gene ID: 8836
mRNA Refseq: NM_003878
Protein Refseq: NP_003869
MIM: 601509
UniProt ID: Q92820
Chromosome Location: 8q12.3

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Optional requirements on this protein    +Expand
C-fusion    N-fusion   Non-tagged
His    GST   Fc   Others
<1.0 eu/μg    <0.1 eu/μg   <0.01 eu/μg   Not required
Monomer Isolation    Dimer Isolation    Not required
>80% by SDS-PAGE    >90% by SDS-PAGE   >95% by SDS-PAGE   Others

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