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Recombinant Human Gamma-Glutamyl Hydrolase (conjugase, folylpolygammaglutamyl hydrolase), His-tagged

Cat.No. : GGH-1399H
Product Overview : Recombinanthuman GGHprotein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventionalchromatography techniques.
  • Specification
  • Gene Information
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Cat. No. : GGH-1399H
Description : GGH is a homodimericprotein that catalyzes the cleavage of the gamma-glutamyl chain offolylpoly-gamma-glutamyl substrates and is a central enzyme in folyl andantifolyl poly-gamma-glutamate metabolism. GGH may play an important role inthe bioavailability of dietary pteroylpolyglutamates and in the metabolism ofpteroylpolyglutamates and antifolates.
Form : Liquid. In 20mMTris-HCl buffer (pH 8.0) containing 1mM DTT, 10% glycerol, 0.1M NaCl.
Molecular Weight : 35.9 kDa(315aa), confirmed by MALDI-TOF.
Purity : > 95%by SDS-PAGE
Concentration : 0.5mg/ml(determined by Bradford assay)
Sequences of aminoacids : MGSSHHHHHHSSGLVPRGSH MRPHGDTAKK PIIGILMQKC RNKVMKNYGR YYIAASYVKY LESAGARVVPVRLDLTEKDY EILFKSINGI LFPGGSVDLR RSDYAKVAKI FYNLSIQSFDDGDYFPVWGT CLGFEELSLL ISGECLLTAT DTVDVAMPLN FTGGQLHSRM FQNFPTELLL SLAVEPLTANFHKWSLSVKN FTMNEKLKKF FNVLTTNTDG KIEFISTMEG YKYPVYGVQW HPEKAPYEWK NLDGISHAPNAVKTAFYLAEFFVNEARKNNHHFKSESEEE KALIYQFSPI YTGNISSFQQ CYIFD
Storage : Can bestored at +4°C short term (1-2 weeks). For long term storage, aliquot andstore at -20°C or -70°C. Avoid repeated freezing and thawing cycles.
OfficialSymbol : GGH
nullValue_other :
PathwaysFluoropyrimidineActivity; Folate biosynthesis
Gene Name : GGH gamma-glutamyl hydrolase(conjugase, folylpolygammaglutamyl hydrolase) [ Homo sapiens ]
Synonyms : GGH; gamma-glutamyl hydrolase (conjugase,folylpolygammaglutamyl hydrolase); GH; gamma-glutamyl hydrolase; gamma-Glu-Xcarboxypeptidase; OTTHUMP00000226541; EC 3.4.19.9; Gamma-glutamyl hydrolase; Conjugase; Gamma-Glu-Xcarboxypeptidase; OTTHUMP00000226541; OTTHUMP00000226558
Gene ID : 8836
mRNA Refseq : NM_003878
Protein Refseq : NP_003869
MIM : 601509
UniProt ID : Q92820
Chromosome Location : 8q12.3

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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