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Recombinant Human Gamma-Glutamyl Hydrolase (conjugase, folylpolygammaglutamyl hydrolase), His-tagged

Cat. No. : GGH-1399H
Product Overview : Recombinanthuman GGHprotein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventionalchromatography techniques.
Description : GGH is a homodimericprotein that catalyzes the cleavage of the gamma-glutamyl chain offolylpoly-gamma-glutamyl substrates and is a central enzyme in folyl andantifolyl poly-gamma-glutamate metabolism. GGH may play an important role inthe bioavailability of dietary pteroylpolyglutamates and in the metabolism ofpteroylpolyglutamates and antifolates.
Form : Liquid. In 20mMTris-HCl buffer (pH 8.0) containing 1mM DTT, 10% glycerol, 0.1M NaCl.
Molecular Weight : 35.9 kDa(315aa), confirmed by MALDI-TOF.
Purity : > 95%by SDS-PAGE
Concentration : 0.5mg/ml(determined by Bradford assay)
Sequences of aminoacids : MGSSHHHHHHSSGLVPRGSH MRPHGDTAKK PIIGILMQKC RNKVMKNYGR YYIAASYVKY LESAGARVVPVRLDLTEKDY EILFKSINGI LFPGGSVDLR RSDYAKVAKI FYNLSIQSFDDGDYFPVWGT CLGFEELSLL ISGECLLTAT DTVDVAMPLN FTGGQLHSRM FQNFPTELLL SLAVEPLTANFHKWSLSVKN FTMNEKLKKF FNVLTTNTDG KIEFISTMEG YKYPVYGVQW HPEKAPYEWK NLDGISHAPNAVKTAFYLAEFFVNEARKNNHHFKSESEEE KALIYQFSPI YTGNISSFQQ CYIFD
Storage : Can bestored at +4°C short term (1-2 weeks). For long term storage, aliquot andstore at -20°C or -70°C. Avoid repeated freezing and thawing cycles.
OfficialSymbol : GGH
nullValue_other :
PathwaysFluoropyrimidineActivity; Folate biosynthesis
Gene Name : GGH gamma-glutamyl hydrolase(conjugase, folylpolygammaglutamyl hydrolase) [ Homo sapiens ]
Synonyms : GGH; gamma-glutamyl hydrolase (conjugase,folylpolygammaglutamyl hydrolase); GH; gamma-glutamyl hydrolase; gamma-Glu-Xcarboxypeptidase; OTTHUMP00000226541; EC 3.4.19.9; Gamma-glutamyl hydrolase; Conjugase; Gamma-Glu-Xcarboxypeptidase; OTTHUMP00000226541; OTTHUMP00000226558
Gene ID : 8836
mRNA Refseq : NM_003878
Protein Refseq : NP_003869
MIM : 601509
UniProt ID : Q92820
Chromosome Location : 8q12.3

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