Native Human Protein Z, Vitamin K-Dependent Plasma Glycoprotein

• Cat.No.: PROZ-5470H
• Product Overview: Native Human PROZ isa glycoprotein derived from fresh frozen plasma by a combination ofprecipitations and column chromatography.

Specification

• Description: Protein Z alsoknown as PROZ is a protein which in humans is encoded by the PROZ gene.Protein Z is a member of the coagulation cascade, the group of blood proteinsthat leads to the formation of blood clots. It is vitamin K-dependent, andits functionality is therefore impaired in warfarin therapy. It is aglycoprotein.
• Source: Human plasma
• Species: Human
• Form: Frozen liquid in0.05M Tris-HCl Buffer + 0.1M NaCl, pH 7.5.
• Molecular Mass: 62 kDa
• Endotoxin: < 0.1 ng/μg ofprotein>
• Purity: ≥95% by SDS-PAGEanalysis. Shows no reduction upon incubation with 2-mercaptoethanol.
• Storage: Store at -80°C.Stable for 3 years from delivery. Avoid repeated freeze/thaw cycles.
• Concentration: 5.0 mg/ml

Gene Information

• Gene Name: PROZ protein Z, vitamin K-dependent plasma glycoprotein [ Homo sapiens ]
• Official Symbol: PROZ
• Synonyms: PROZ; protein Z, vitamin K-dependent plasma glycoprotein; vitamin K-dependent protein Z; PZ
• Gene ID: 8858
• mRNA Refseq: NM_001256134
• Protein Refseq: NP_001243063
• MIM: 176895
• UniProt ID: P22891
• Chromosome Location: 13q34
• Pathway: Gamma-carboxylation of protein precursors, organism-specific biosystem; Gamma-carboxylation, transport, and amino-terminal cleavage of proteins, organism-specific biosystem; Metabolism of proteins, organism-specific biosystem; PTM: gamma carboxylation, hypusine formation and arylsulfatase activation, organism-specific biosystem; Post-translational protein modification, organism-specific biosystem; Removal of aminoterminal propeptides from gamma-carboxylated proteins, organism-specific biosystem; Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus, organism-specific biosystem
• Function: calcium ion binding; catalytic activity; serine-type endopeptidase activity