Native Human Sex Hormone-Binding Globulin
Cat.No. : | SHBG-5519H |
Product Overview : | Native human SHBG wasexpressed in Human pregnancy plasma,which having a molecule weight of80 kDa. |
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- Gene Information
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Description : | SHBG or sexsteroid-binding globulin (SSBG) is a glycoprotein that binds to sex hormones,to be specific, testosterone and estradiol. Other steroid hormones such asprogesterone, cortisol, and other corticosteroids are bound by transcortin. Testosteroneand estradiol circulate in the bloodstream, bound mostly to SHBG and to somedegree bound to serum albumin. Only a small fraction is unbound and thus biologically active and able to enter a cell andactivate its receptor. The SHBG inhibits the function of these hormones.Thus, bioavailability of sex hormones is influenced by the level of SHBG. |
Source : | Human pregnancyplasma |
Species : | Human |
Form : | Lyophilized from 0.1M Sodium Phosphate buffer, pH 7.4, without preservative. |
Molecular Mass : | 80 kDa |
Purity : | ≥98% asdetermined by SDS PAGE analysis |
Storage : | Upon receipt storelyophilized at -20°C. Reconstituted product should also be stored at -20°C.Avoid repeated freeze-thaw cycles. |
Concentration : | 1 mg/vial |
Reconstitution : | Centrifuge vialprior to opening. Allow vial to warm to room temperature, then dissolve inlaboratory grade water or buffer. Do not use buffers containing divalentmetal ions (Ca2, Mg2, etc.) |
Gene Name : | SHBG sex hormone-binding globulin [ Homo sapiens ] |
Official Symbol : | SHBG |
Synonyms : | SHBG; sex hormone-binding globulin; ABP; androgen binding protein; MGC126834; MGC138391; TEBG; sex steroid-binding protein; testosterone-binding beta-globulin; testosterone-estrogen-binding globulin; testosterone-estradiol-binding globulin; testis-specifi |
Gene ID : | 6462 |
mRNA Refseq : | NM_001040 |
Protein Refseq : | NP_001031 |
MIM : | 182205 |
UniProt ID : | P04278 |
Chromosome Location : | 17pter-p12 |
Pathway : | Nongenotropic Androgen signaling, organism-specific biosystem; |
Function : | androgen binding; protein homodimerization activity; |
Products Types
◆ Recombinant Protein | ||
Shbg-5853M | Recombinant Mouse Shbg Protein, Myc/DDK-tagged | +Inquiry |
SHBG-8140M | Recombinant Mouse SHBG Protein, His (Fc)-Avi-tagged | +Inquiry |
SHBG-0054H | Recombinant Human SHBG Protein | +Inquiry |
SHBG-1228H | Recombinant Human SHBG Protein, His-tagged | +Inquiry |
SHBG-5048R | Recombinant Rat SHBG Protein, His (Fc)-Avi-tagged | +Inquiry |
◆ Native Protein | ||
SHBG-8259H | Native Human Serum Sex Hormone Binding Globulin | +Inquiry |
SHBG-30637TH | Native Human SHBG protein | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (7)
Ask a questionSHBG interacts with cell surface receptors, influencing cellular responses to sex hormones.
SHBG levels are used to assess free testosterone levels, helping diagnose hormonal imbalances.
Factors influencing SHBG levels include age, sex, hormonal balance, and certain medical conditions.
Abnormally high SHBG can reduce free testosterone, potentially leading to hypogonadism, while low SHBG can increase free testosterone, possibly contributing to conditions like polycystic ovary syndrome (PCOS) and insulin resistance.
SHBG is predominantly produced in the liver.
SHBG binds and transports sex hormones, particularly testosterone and estradiol, in the bloodstream.
By binding sex hormones, SHBG controls their free, bioavailable forms and regulates their activity.
Customer Reviews (3)
Write a reviewVery satisfied, worked perfectly.
Fast shipping, product perfect.
Excellent results in assay.
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