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Native Human Sex Hormone-Binding Globulin

Cat.No. : SHBG-5519H
Product Overview : Native human SHBG wasexpressed in Human pregnancy plasma,which having a molecule weight of80 kDa.
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Description : SHBG or sexsteroid-binding globulin (SSBG) is a glycoprotein that binds to sex hormones,to be specific, testosterone and estradiol. Other steroid hormones such asprogesterone, cortisol, and other corticosteroids are bound by transcortin. Testosteroneand estradiol circulate in the bloodstream, bound mostly to SHBG and to somedegree bound to serum albumin. Only a small fraction is unbound and thus biologically active and able to enter a cell andactivate its receptor. The SHBG inhibits the function of these hormones.Thus, bioavailability of sex hormones is influenced by the level of SHBG.
Source : Human pregnancyplasma
Species : Human
Form : Lyophilized from 0.1M Sodium Phosphate buffer, pH 7.4, without preservative.
Molecular Mass : 80 kDa
Purity : ≥98% asdetermined by SDS PAGE analysis
Storage : Upon receipt storelyophilized at -20°C. Reconstituted product should also be stored at -20°C.Avoid repeated freeze-thaw cycles.
Concentration : 1 mg/vial
Reconstitution : Centrifuge vialprior to opening. Allow vial to warm to room temperature, then dissolve inlaboratory grade water or buffer. Do not use buffers containing divalentmetal ions (Ca2, Mg2, etc.)
Gene Name : SHBG sex hormone-binding globulin [ Homo sapiens ]
Official Symbol : SHBG
Synonyms : SHBG; sex hormone-binding globulin; ABP; androgen binding protein; MGC126834; MGC138391; TEBG; sex steroid-binding protein; testosterone-binding beta-globulin; testosterone-estrogen-binding globulin; testosterone-estradiol-binding globulin; testis-specifi
Gene ID : 6462
mRNA Refseq : NM_001040
Protein Refseq : NP_001031
MIM : 182205
UniProt ID : P04278
Chromosome Location : 17pter-p12
Pathway : Nongenotropic Androgen signaling, organism-specific biosystem;
Function : androgen binding; protein homodimerization activity;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (7)

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How does SHBG interact with other proteins and receptors in the body? 12/07/2022

SHBG interacts with cell surface receptors, influencing cellular responses to sex hormones.

How is SHBG used as a diagnostic marker in clinical settings? 08/21/2022

SHBG levels are used to assess free testosterone levels, helping diagnose hormonal imbalances.

What factors can influence the levels of SHBG in the bloodstream? 04/16/2022

Factors influencing SHBG levels include age, sex, hormonal balance, and certain medical conditions.

What are the implications of abnormally high or low levels of SHBG? 03/19/2022

Abnormally high SHBG can reduce free testosterone, potentially leading to hypogonadism, while low SHBG can increase free testosterone, possibly contributing to conditions like polycystic ovary syndrome (PCOS) and insulin resistance.

In which organs or tissues is SHBG predominantly produced? 09/06/2021

SHBG is predominantly produced in the liver.

What is the primary biological role of Sex Hormone-Binding Globulin (SHBG) in the body? 01/23/2020

SHBG binds and transports sex hormones, particularly testosterone and estradiol, in the bloodstream.

How does SHBG regulate the bioavailability of sex hormones? 01/08/2020

By binding sex hormones, SHBG controls their free, bioavailable forms and regulates their activity.

Customer Reviews (3)

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Reviews
10/27/2022

    Very satisfied, worked perfectly.

    09/15/2021

      Fast shipping, product perfect.

      04/06/2021

        Excellent results in assay.

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