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Native Human Sex Hormone-Binding Globulin

Cat.No.: SHBG-5519H
Product Overview: Native human SHBG wasexpressed in Human pregnancy plasma,which having a molecule weight of80 kDa.
Description: SHBG or sexsteroid-binding globulin (SSBG) is a glycoprotein that binds to sex hormones,to be specific, testosterone and estradiol. Other steroid hormones such asprogesterone, cortisol, and other corticosteroids are bound by transcortin. Testosteroneand estradiol circulate in the bloodstream, bound mostly to SHBG and to somedegree bound to serum albumin. Only a small fraction is unbound and thus biologically active and able to enter a cell andactivate its receptor. The SHBG inhibits the function of these hormones.Thus, bioavailability of sex hormones is influenced by the level of SHBG.
Source: Human pregnancyplasma
Species: Human
Form: Lyophilized from 0.1M Sodium Phosphate buffer, pH 7.4, without preservative.
Molecular Mass: 80 kDa
Purity: ≥98% asdetermined by SDS PAGE analysis
Storage: Upon receipt storelyophilized at -20°C. Reconstituted product should also be stored at -20°C.Avoid repeated freeze-thaw cycles.
Concentration: 1 mg/vial
Reconstitution: Centrifuge vialprior to opening. Allow vial to warm to room temperature, then dissolve inlaboratory grade water or buffer. Do not use buffers containing divalentmetal ions (Ca2, Mg2, etc.)
Gene Name: SHBG sex hormone-binding globulin [ Homo sapiens ]
Official Symbol: SHBG
Synonyms: SHBG; sex hormone-binding globulin; ABP; androgen binding protein; MGC126834; MGC138391; TEBG; sex steroid-binding protein; testosterone-binding beta-globulin; testosterone-estrogen-binding globulin; testosterone-estradiol-binding globulin; testis-specifi
Gene ID: 6462
mRNA Refseq: NM_001040
Protein Refseq: NP_001031
MIM: 182205
UniProt ID: P04278
Chromosome Location: 17pter-p12
Pathway: Nongenotropic Androgen signaling, organism-specific biosystem;
Function: androgen binding; protein homodimerization activity;

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