Native Human Thyroid Peroxidase

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Native Human Thyroid Peroxidase

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Cat. No. : TPO-702H
Product Overview : Native human TPO is purifiedHuman Thyroid Glands.
Description : Thyroid Peroxidase(TPO) is a membrane-bound glycoprotein. TPO acts as an enzyme and plays acentral role in thyroid gland function. It functions in the iodination oftyrosine residues in thyroglobulin and phenoxy-ester formation between pairsof iodinated tyrosines to generate the thyroid hormones, Thyroxine andTriiodothyronine. Mutations in TPO are associated with several disorders ofthyroid hormonogenesis, including congenital hypothyroidism, congenitalgoiter, and thyroid hormone organification defect IIA.
Source : Human Thyroid Glands
Form : Liquid in 20 mM Tris+ 50 mM KCl, pH 7.5 without preservative
Concentration : 1.0 mg/mL
Purity : >98% by SDS-PAGE
Storage : Store in workingaliquots at -20°C. Avoid repeated freeze-thaw cycles.
OfficialSymbol : TPO
Gene Name : TPO thyroid peroxidase [ Homosapiens ]
Synonyms : TPO; thyroidperoxidase; MSA; TPX; TDH2A; thyroperoxidase; OTTHUMP00000115303;OTTHUMP00000115304; OTTHUMP00000115535; OTTHUMP00000115536; thyroidmicrosomal antigen; EC 1.11.1.8; EC 1.11.1
Gene ID : 7173
mRNA Refseq : NM_000547
Protein Refseq : NP_000538
MIM : 606765
UniProt ID : P07202
Chromosome Location : 2p25
Pathway : Amine-derivedhormones; Autoimmune thyroid disease; Cytokine-cytokine receptor interaction;Hematopoietic cell lineage; Jak-STAT signaling pathway; Metabolic pathways;Metabolism; Metabolism of amino acids and derivatives; Thyroid hormonebiosynthesis; Thyroxine biosynthesis; Tyrosine metabolism
Function : calcium ion binding;heme binding; iodide peroxidase activity; oxidoreductase activity; peroxidaseactivity

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