Recombinant Human Titin
| Cat.No. : |
TTN-705H |
| Product Overview : |
Recombinant human TTNcontains 6 Immunoglobulin-like do mains from the I-band region and can beused as a force and length standard for atomic force spectroscopy. |
- Specification
- Gene Information
- Related Products
| Cat. No. : |
TTN-705H |
| Description : |
TTN is the largestknown protein. Next to actin and myosin, titin is the third most abundantprotein in the striated muscle sarcomere, providing passive tension to muscleand acting as a template for sarcomere formation. Titin is important in thecontraction of striated muscle tissues. It connects the Z line to the M linein the sarcomere. The protein contributes to force transmission at the Z lineand resting tension in the I band region. It limits the range of motion ofthe sarcomere in tension, thus contributing to the passive stiffness ofmuscle. Variations in the sequence of titin between different types of musclehas been correlated with differences in the mechanical properties of thesemuscles. |
| Source : |
E. coli |
| Species : |
Human |
| Form : |
Liquid. Supplied in20 mM HEPES-KOH pH 7.0, 50 mM NaCl, 1 mM EDTA and 1 Mm DTT. |
| Purity : |
>95% by SDS-PAGE |
| Endotoxin Level : |
< 0.1 ng/µg ofprotein |
| Storage : |
When stored at-80°C, product is stable for 1 year from date of delivery. |
| OfficialSymbol : |
TTN |
| Gene Name : |
TTN titin [ Homo sapiens] |
| Synonyms : |
TTN; titin; TMD;CMH9; CMD1G; CMPD4; EOMFC; FLJ32040; FLJ26020; FLJ26409; FLJ34413; FLJ39564;FLJ43066; HMERF; MYLK5; LGMD2J; MPRM; DKFZp451N061; connectin; OTTHUMP00000233809;OTTHUMP00000233810; rhabdomyosarcoma antigen MU-RMS-40.14; cardiomyopathy,dilated 1G (autosomal dominant); EC 2.7.11.1 |
| Gene ID : |
7273 |
| mRNA Refseq : |
NM_003319 |
| Protein Refseq : |
NP_003310 |
| MIM : |
188840 |
| UniProt ID : |
E9PPD3 |
| Chromosome Location : |
2q31 |
| Pathway : |
Dilated cardiomyopathy;Hemostasis; Hypertrophic cardiomyopathy (HCM); Muscle contraction; Plateletactivation; Platelet degranulation; Response to elevated platelet cytosolicCa2+; Striated Muscle Contraction |
| Function : |
ATP binding; actinfilament binding; alpha-actinin binding; calcium ion binding; calmodulinbinding; identical protein binding; muscle alpha-actinin binding; nucleicacid binding; nucleotide binding; protein binding; protein self-association;protein serine/threonine kinase activity; protein tyrosine kinase activity;structural constituent of muscle; telethonin binding |
Products Types
Related Gene
TTN
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
