"TTN" Related Products


Recombinant Human Titin

Cat. No. : TTN-705H
Product Overview : Recombinant human TTNcontains 6 Immunoglobulin-like do mains from the I-band region and can beused as a force and length standard for atomic force spectroscopy.
Description : TTN is the largestknown protein. Next to actin and myosin, titin is the third most abundantprotein in the striated muscle sarcomere, providing passive tension to muscleand acting as a template for sarcomere formation. Titin is important in thecontraction of striated muscle tissues. It connects the Z line to the M linein the sarcomere. The protein contributes to force transmission at the Z lineand resting tension in the I band region. It limits the range of motion ofthe sarcomere in tension, thus contributing to the passive stiffness ofmuscle. Variations in the sequence of titin between different types of musclehas been correlated with differences in the mechanical properties of thesemuscles.
Source : E. coli
Species : Human
Form : Liquid. Supplied in20 mM HEPES-KOH pH 7.0, 50 mM NaCl, 1 mM EDTA and 1 Mm DTT.
Purity : >95% by SDS-PAGE
Endotoxin Level : < 0.1 ng/µg ofprotein
Storage : When stored at-80°C, product is stable for 1 year from date of delivery.
OfficialSymbol : TTN
Gene Name : TTN titin [ Homo sapiens]
Synonyms : TTN; titin; TMD;CMH9; CMD1G; CMPD4; EOMFC; FLJ32040; FLJ26020; FLJ26409; FLJ34413; FLJ39564;FLJ43066; HMERF; MYLK5; LGMD2J; MPRM; DKFZp451N061; connectin; OTTHUMP00000233809;OTTHUMP00000233810; rhabdomyosarcoma antigen MU-RMS-40.14; cardiomyopathy,dilated 1G (autosomal dominant); EC
Gene ID : 7273
mRNA Refseq : NM_003319
Protein Refseq : NP_003310
MIM : 188840
UniProt ID : E9PPD3
Chromosome Location : 2q31
Pathway : Dilated cardiomyopathy;Hemostasis; Hypertrophic cardiomyopathy (HCM); Muscle contraction; Plateletactivation; Platelet degranulation; Response to elevated platelet cytosolicCa2+; Striated Muscle Contraction
Function : ATP binding; actinfilament binding; alpha-actinin binding; calcium ion binding; calmodulinbinding; identical protein binding; muscle alpha-actinin binding; nucleicacid binding; nucleotide binding; protein binding; protein self-association;protein serine/threonine kinase activity; protein tyrosine kinase activity;structural constituent of muscle; telethonin binding

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